Abstract
Having demonstrated that nonsymmetric cephalostatin analogues are superior in biological activity to their symmetric counterparts we here report on further possibilities for desymmetrization of the readily available diketone 4. Since monoenolates had been prepared at an earlier stage, we describe here the selectivity of phenyl-iodosyldiacetate oxidations under basic conditions and as an example of selective nucleophilic attack, the Wittigmethylenation at the 12-ketogroup followed by a hydroboration is documented.
Keywords: nonsymmetric cephalostatin analogous, desymmetrization Reactions, monoenolates, phenyl-iodosyldiacetate oxidations
Current Organic Chemistry
Title: Novel Routes to Nonsymmetric Cephalostatin Analogous
Volume: 7 Issue: 7
Author(s): M. Nawasreh and E. Winterfeldt
Affiliation:
Keywords: nonsymmetric cephalostatin analogous, desymmetrization Reactions, monoenolates, phenyl-iodosyldiacetate oxidations
Abstract: Having demonstrated that nonsymmetric cephalostatin analogues are superior in biological activity to their symmetric counterparts we here report on further possibilities for desymmetrization of the readily available diketone 4. Since monoenolates had been prepared at an earlier stage, we describe here the selectivity of phenyl-iodosyldiacetate oxidations under basic conditions and as an example of selective nucleophilic attack, the Wittigmethylenation at the 12-ketogroup followed by a hydroboration is documented.
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Cite this article as:
Nawasreh M. and Winterfeldt E., Novel Routes to Nonsymmetric Cephalostatin Analogous, Current Organic Chemistry 2003; 7 (7) . https://dx.doi.org/10.2174/1385272033486774
DOI https://dx.doi.org/10.2174/1385272033486774 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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