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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Insulin and the Blood-Brain Barrier

Author(s): Stephen C. Woods, Randy J. Seeley, Denis G. Baskin and Michael W. Schwartz

Volume 9, Issue 10, 2003

Page: [795 - 800] Pages: 6

DOI: 10.2174/1381612033455323

Price: $65

Abstract

Although several possible mechanisms exist by which the pancreatic hormone, insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters primarily by a receptor-mediated transport process. Many factors influence the rate of entry, including fasting and refeeding and several pathological conditions. Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition.

Keywords: Insulin, Blood-Brain Barrier, homeostasis


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