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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Membrane Receptors for Vitamin D Steroid Hormones: Potential NewDrug Targets

Author(s): M. C. Farach-Carson and I. Nemere

Volume 4, Issue 1, 2003

Page: [67 - 76] Pages: 10

DOI: 10.2174/1389450033347118

Price: $65

Abstract

There is increasing evidence that steroid hormones derived from vitamin D act through classical nuclear receptors (nVDR), as well as specific binding sites on the plasma membrane of target cells that are coupled to signal transduction systems. These sites are referred to as M embrane A ssociated, R apid R esponse S teroid (MARRS) binding proteins or complexes. In the case of the seco-steroid 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the two

Keywords: Vitamin D, Steroid, Hormones, Osteoclasts, immunohistochemical, 1,25D3-MARRS


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