Medicinal Chemistry

Editor-in-Chief

Dimitra Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy
Aristotle University of Thessaloniki
Thessaloniki
(Greece)

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

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Most Accessed Articles

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Volume: 17   Issue: 10
Pp: 1073-1085
Vitor F. Ferreira*, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva
DOI: 10.2174/1573406416666201106104756

Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

Volume: 17   Issue: 10
Pp: 1207-1218
Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada*
DOI: 10.2174/1573406416666200817160708

Design, Synthesis, and Anti-Neuroinflammatory Activity of Amide- Containing Dithiolethiones

Volume: 17   Issue: 10
Pp: 1166-1174
Karrington Craig, Paula Avila and Dennis A. Brown*
DOI: 10.2174/1573406416666200909105100

Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Volume: 17   Issue: 10
Pp: 1151-1165
Giada Righetti, Michele Tonelli*, Paola Fossa and Elena Cichero*
DOI: 10.2174/1573406416666201106110611

Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

Volume: 17   Issue: 10
Pp: 1086-1103
Georgios Papagiouvannis*, Panagiotis Theodosis-Nobelos, Panos N. Kourounakis and Eleni A. Rekka
DOI: 10.2174/1573406416666201013161303

Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Volume: 17   Issue: 10
Pp: 1129-1139
Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco
DOI: 10.2174/1573406416666201120103913

Synthesis and Structure-Activity Relationship Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

Volume: 17   Issue: 9
Pp: 1046-1059
Wei-Wei Ni, Hai-Lian Fang, Ya-Xi Ye, Wei-Yi Li, Li Liu, Zi-Juan Fu, Dawalamu, Wen-Yan Zhu, Ke Li, Fang Li, Xia Zou, Hui Ouyang, Zhu-Ping Xiao* and Hai-Liang Zhu*
DOI: 10.2174/1573406416999200818152440

Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines

Volume: 17   Issue: 9
Pp: 945-955
Délis Galvão Guimarães, Arlan de Assis Gonsalves, Larissa Araújo Rolim, Edigênia Cavalcante Araújo, Victória Laysna dos Anjos Santos, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Marcília Pinheiro da Costa, Claudia Pessoa, Marília Oliveira Fonseca Goulart, Thaissa Lucio Silva, Danyelle Cândido Santos and Cleônia Roberta Melo Araújo*
DOI: 10.2174/1573406416666200817164308

Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship

Volume: 17   Issue: 9
Pp: 1023-1045
M. del Carmen Salazar-López, J. Alberto Guevara-Salazar*, Mónica G. Arellano-Mendoza, Hugo A. Jiménez-Vázquez, Adriana Benavides and Delia Quintana-Zavala
DOI: 10.2174/1573406416666200930113511

Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

Volume: 17   Issue: 9
Pp: 963-973
Altannavch Nyamsambuu, Ashfaque Ahmed, Farjana Yeasmin Khusbu, Sarangerel Oidovsambuu, Md. Asaduzzaman Khan, Xi Zhou, Jun-jiang Fu and Han-Chun Chen*
DOI: 10.2174/1573406416666201106110117

Origanum vulgare L.: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Volume: 17   Issue: 9
Pp: 983-993
Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M. Jachak, Sangdun Choi and Mubashir Hussain Masoodi*
DOI: 10.2174/1573406416666200904110828

Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

Volume: 17   Issue: 9
Pp: 937-944
Reema Abu Khalaf*, Haya Abu Jarad, Tariq Al-Qirim and Dima Sabbah
DOI: 10.2174/1573406416666200917105401

Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity

Volume: 17   Issue: 9
Pp: 994-1006
Bhim Bahadur Chaudhari, Alka Bali* and Ajitesh Balaini
DOI: 10.2174/1573406416666200930114340

Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives

Volume: 17   Issue: 9
Pp: 974-982
Kai-Xia Zhang, Xi-Jing Qian, Wei Zheng, Meng-Cheng Cai, Ying Ma, Da-Zhi Zhang, Shi-Chong Yu, Qing-Guo Meng* and Yong-Sheng Jin*
DOI: 10.2174/1573406416999200818150053

Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects

Volume: 17   Issue: 9
Pp: 956-962
Syed Nasir Abbas Bukhari*, Nasser Hadal Alotaibi, Waqas Ahmad, Khalid Saad Alharbi, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Muhammad Masood Ahmad, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja and Muhammad Ajaz Hussain
DOI: 10.2174/1573406416666200905125038