Medicinal Chemistry

Xanthone: A Promising Antimycobacterial Scaffold

Volume:16
Tilal Elsaman, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla and Magdi Awadalla Mohamed*

Chalcones: As potent α-amylase enzyme inhibitors; synthesis, in vitro, and in silico studies

Volume:16
Mahboob Ali, Momin Khan, Khair Zaman, Abdul Wadood, Maryam Iqbal, Aftab Alam, Sana Shah, Ashfaq Ur Rehman, Muhammad Yousaf, Rafaila Rafique and Khalid Mohammed Khan*

Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study.

Volume:16
Uma Krithika, Prabitha P, Subhankar P. Mandal, Yuvaraj S, Priya D, Ashish D Wadhwani and B. R. Prashantha Kumar*

Design and Synthesis of arylnaphthalene lignan lactones derivatives as Potent Topoisomerase Inhibitors

Volume:16
Wang Chen, Zili Feng*, Daihua Hu and Jin Meng

Spiro Heterocyclic Compounds as Potential Anti-Alzheimer agents (Part 2): their Metal Chelation Capacity, POM Analyses and DFT Studies

Volume:16
Taibi Ben Hadda, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan, Hsaine Zgou, Abdur Rauf, Yahia Nasser Mabkhot, Brahim Bennani, Dalia R. Emam, Nabila Abdelshafy Kheder, Abdulrhman Asayari, Abdullatif Bin Muhsinah and Aneela Maalik*

Synthesis, Anticancer, and Antibacterial Studies of Benzylidene Bearing 5-substituted and 3,5-disubstituted-2,4-Thiazolidinedione Derivatives

Volume:16
Navjot Singh Sethi, Deo Nandan Prasad and Rajesh K. Singh*

Synthesis of thiazolyl-N-phenylmorpholine Derivatives and their Biological Activities

Volume:16
Amerah M. Al-Soliemy, Thoraya A. Farghaly, Eman M. H. Abbas, Mohamed R. Shaaban*, Mohie E. M. Zayed and Tarek B. A. El-Naggar

Novel Aminopyrazole Tagged Hydrazones as Anti-Tubercular Agents: Synthesis and Molecular Docking Studies

Volume:16
Thatavarthi Padmini, Darna Bhikshapathi, Kandagatla Suresh, Ravindra Kulkarni* and Bigala Raj Kamal

Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4-Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro

Volume:16
Lucas da Silva Santos, Matheus Fillipe Langanke de Carvalho, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Julio César Dias Lopes, Fernando de Pilla Varotti, Rossimiriam Pereira de Freitas and Rosemeire Brondi Alves*

Pyrazole derivatives of medically relevant phenolic acids: insight into antioxidative and anti-LOX activity

Volume:16
Vesna Milovanović, Zorica D. Petrović*, Slađana Novaković, Goran A. Bogdanović, Dušica Simijonović, Milan Mladenović, Jovica Branković and Vladimir P. Petrović

Synthesis and Cytotoxic Activity of Novel Mono- and Bis-Indole Derivatives: Analogues of Marine Alkaloid Nortopsentin

Volume:16
Mona Monir Kamel, Mohamed Kamal Abdel-hameid, Hala Bakr El-Nassan* and Eman Adel El-Khouly

DFT Studies of Distinct Anilines with p-Hydroxycinnamic Acids for Antioxidant Profile

Volume:16
Ch. Ravi Shankar Kumar*, Anjali Jha and S. Deepthi

Synthesis and anticancer activity of thiadiazole containing thiourea, benzothiazole and imidazo[2,1-b][1,3,4]thiadiazole scaffolds

Volume:16
Stephen Paul Avvaru, Malleshappa N. Noolvi*, Uttam A More, Sudipta Chakraborty, Ashutosh Dash, Tejraj M Aminabhavi, Kumar P Narayan and Vishnu Sutariya

Synthesis and Erythroid Induction Activity of New Thiourea Derivatives

Volume:16
Hina Siddiqui*, Sarah Shafi, Hamad Ali and Syed Ghulam Musharraf

Synthesis of New Thioureas Derivatives and Evaluation of Their Efficacy as Proliferation Inhibitors in MCF-7 Breast Cancer Cells by Using 99mTc- MIBI Radiotracer

Volume:16
Ahmad Hormati, Jafar Abbasi Shiran, Mikaeil Molazadeh, Babak Kaboudin and Sajjad Ahmadpour*

Structure-Based Virtual Screening of New Benzoic Acid Derivatives as Trypanosoma cruzi Trans-sialidase Inhibitors

Volume:16
Lenci Karina Vázquez-Jiménez, Alma Delia Paz-González, Alfredo Juárez-Saldivar, María Laura Uhrig, Rosalía Agusti, Alicia Reyes-Arellano, Benjamín Nogueda-Torres and Gildardo Rivera*

Curcumin-based antioxidant and glycohydrolase inhibitor compounds: Synthesis and in vitro appraisal of the dual activity against diabetes

Volume:16
Sajjad Esmaeili, Nazanin Ghobadi, Donya Nazari, Alireza Pourhossein, Hassan Rasouli, Hadi Adibi and Reza Khodarahmi*

Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation

Volume:16
Tran Khac Vu*, Nguyen Thi Thanh, Nguyen Van Minh, Nguyen Huong Linh, Nguyen Thi Phương Thao, Trương Thuc Bao Nguyen, Doan Thi Hien, Luu Van Chinh, Ta Hong Duc, Lai Duc Anh and Pham-The Hai

Synthesis, Molecular Docking Studies and Antibacterial Activities of Novel Monocationic Indole-benzimidazole Derivatives

Volume:16
Zeynep Ates-Alagoz*, Mehmet Murat Kisla, Hakan Goker and Sulhiye Yildiz

Synthesis, Molecular Modeling of Novel Substituted Pyridazinones and their Vasorelaxant Activities

Volume:16
Magda Ismail, Dalia Soliman*, Mona H. Abd Elmoniem and Ghehad Abdel Raheem Abdel Jaleel

Synthesis and Antimicrobial Activity of Novel 1, 2, 4-Triazolopyrimidofuro- quinazolinones from Natural Furochromones (Visnagenone and Khellinone)

Volume:16
Ameen Ali Abu-Hashem*, Hoda A. R. Hussein and Ahmed S. Aly

Synthesis of new Enrofloxacin Derivatives as Potential Antibiofilm Drugs Against Staphylococcus Aureus and Klebsiella Pneumoniae

Volume:16
Hina Siddiqui *, Haroon Mohamed Haniffa, Ayaz Ahmed and Muhammad Iqbal Choudhary*

Denouement of Chemicals on Amyotrophic Lateral Sclerosis: Is Green Chemistry the Answer

Volume:16
Faizana Fayaz, Faheem Hyder Pottoo, Sadat Shafi, Mushtaq Ahmad Wani, Sharad Wakode* and Anjali Sharma

2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Antiglioma Activities in C6 and GL261 Cells

Volume:16
Alana de Vasconcelos, Ana Júlia Zulian Boeira, Bruna Bento Drawanz, Nathalia Stark Pedra, Natália Pontes Bona, Francieli Moro Stefanello and Wilson Cunico*

In silico Studies on the Interaction Between Bioactive Ligands and DPPIV: Insights on Potential Candidates for the Treatment of type 2 Diabetes Mellitus

Volume:16
Michelle Cristiane Melo Reis Martins, Simone Queiroz Pantaleao, Michell de Oliveira Almeida, Karen Cacilda Weber and Kathia Maria Honorio*

Synthesis and Antioxidant Activity of New Selenium-Containing Quinolines

Volume:16
Benedetta Bocchini, Bruna Goldani, Fernanda S.S. Sousa, Paloma T. Birmann, Cesar A. Brüning, Eder J. Lenardão, Claudio Santi, Lucielli Savegnago and Diego Alves*

The Interaction of Schistosoma Japonicum Glutathione Transferase with Cibacron Blue 3GA and its Fragments

Volume:16
Michalis Platis, Dimitrios Vlachakis, Ahmed Ibrahim Foudah, Magdy Mohamed Muharram, Mohamed Hamed Alqarni, Anastassios C. Papageorgiou and Nikolaos E. Labrou*

Tyramine Derivatives as Potent Therapeutics for Type 2 Diabetes: Synthesis and In Vitro Inhibition of α-Glucosidase Enzyme

Volume:16
M. Arslan Bashir, Kulsoom Javaid, Muniza Shaikh, M. Iqbal Choudhary* and Hina Siddiqui*

Synthesis, Molecular Docking and Biological Evaluation of Novel Flavone Derivatives as Potential Anticancer Agents Targeting Akt

Volume:16
Heba Abosalem, Abdullah Gibriel*, Mohamed Al-Awady and Adel Mandour

Molecular Docking and Dynamics Simulation Analysis of Thymoquinone and Thymol Compounds from Nigella sativa L. that Inhibit Cag A and Vac A Oncoprotein of Helicobacter pylori: Probable Treatment of H. pylori Infections

Volume:16
Heena Tabassum and Iffat Zareen Ahmad*

Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Volume:16
Archana Awasthi, Mantripragada Bhagavan Raju and Md Azizur Rahman*

Withdrawal Notice: The Design, Synthesis, Pharmacokinetic and Pharmacodynamic Evaluation of Acyloxyalkyl-substituted T705 Prodrugs

Volume:15
Xingzhou Li, Tianhong Zhang and Wu Zhong

The Valuable Impacts of Halophytic Genus Suaeda; Nutritional, Chemical, and Biological Values

Volume:16
Hamdoon A. Mohammed*

New Approaches in Sensing and Targeting Bacterial rRNA A-site

Volume:16
Preethi Parameswaran, Nihar Ranjan* and S.J.S. Flora*

Phytochemical Screening, Cytotoxicity and Anti-inflammatory Activities of the Leaf Extracts from Lawsonia inermis of Indian Origin to Explore their Potential for Medicinal Uses

Volume:16
Anju Manuja*, Nitu Rathore, Shalki Chaudhary and Balvinder Kumar

Design, Synthesis and Antitumor Assessment of Phenylureas Bearing 5- Fluoroindolin-2-one Moiety

Volume:16
Yunrui Cai, Tong Chen, Huajian Zhu and Hongbin Zou*

Herbal Medicine for Glioblastoma: Current and Future Prospects

Volume:16
Imran Khan, Sadaf Mahfooz and Mustafa Aziz Hatiboglu*

Synthesis and Structure-activity Relationship of Aminoarylthiazole Derivatives as Potential Potentiators of the Chloride Transport Defect in Cystic Fibrosis

Volume:16
Nara Liessi, Emanuela Pesce, Annalisa Salis, Gianluca Damonte, Bruno Tasso, Elena Cichero, Nicoletta Pedemonte and Enrico Millo*

Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives

Volume:16
Camila Capelini, Vitória R. F. Câmara, José D. Figueroa Villar, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Policarpo A. Sales Junior, Silvane M. F. Murta, Thais B. Couto, Maria Cristina S. Lourenço, James L. Wardell, John N. Low, Edson F. da Silva and Samir A. Carvalho*

Elucidating Molecular Interactions of Ten Natural Compounds Targeting E6 HPV High Risk Oncoproteins Using Microsecond Molecular Dynamics Simulations

Volume:16
Thuluz Meza-Menchaca, Marcela Lizano-Soberón, Angel Trigos, Rossana C. Zepeda, Manuel E. Medina and Rodrigo Galindo-Murillo*

A Comprehension into Target Binding and Spatial Fingerprints of Noscapinoid Analogues as Inhibitors of Tubulin

Volume:16
Seema Mandavi, Renu Bhatt, Sant Kumar Verma, Laxmi Banjare, Amit Dubey, Suresh Thareja and Akhlesh Kumar Jain*

Design, Synthesis, and Biological Evaluation of 4-amino Substituted 2Hchromen- 2-one Derivatives as an NEDD8 Activating Enzyme Inhibitor in Pancreatic Cancer Cells

Volume:16
Lijuan Zhu, Peng Lu, Lei Gong, Cheng Lu, Mengli Li and Yubin Wang*

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy

Volume:16
Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*

Synthesis and 4D-QSAR Studies of Alanine Hydroxamic Acid Derivatives as Aminopeptidase N Inhibitors

Volume:16
Min Gao, Qiao Li Lv, Hou Pan Zhang and Guo Gang Tu*

Antidiabetic Activity of Dihydropyrimidine Scaffolds and Structural Insight by Single Crystal X-ray Studies

Volume:16
Keshab M. Bairagi, Nancy Safwat Younis, Promise Madu Emeka, Ekta Sangtani, Rajesh G. Gonnade, Katharigatta N. Venugopala, Osama I. Alwassil, Hany Ezzat Khalil and Susanta K. Nayak*

Molecular Docking Studies Reveal Rhein from rhubarb (Rheum rhabarbarum) as a Putative Inhibitor of ATP-binding Cassette Super Family G member 2

Volume:16
Muhammad Saad Khan, Bareera Mehmood, Qudsia Yousafi, Shabana Bibi, Sahar Fazal, Shahzad Saleem, Muhammad Wasim Sajid, Awais Ihsan, Muhammad Azhar and Mohammad Amjad Kamal*

In-silico Design, Synthesis and Evaluation of Novel Series of Benzothiazole- Based Pyrazolidinediones as Potent Hypoglycemic Agents

Volume:16
Michelyne Haroun*

“Microwave Assisted Synthesis and Molecular Docking Studies of Some 4 - (3H)-quinazolinone Derivatives as Inhibitors of Human Gamma- Aminobutyric Acid Receptor, the GABA (A)R-BETA3 Homopentamer”

Volume:16
Amrutkar Rakesh Devidas* and Mahendra Sing Ranawat

The Introduction of Hydrazone, Hydrazide, or Azepane Moieties to the Triterpenoid Core Enhances an Activity Against M. tuberculosis

Volume:16
Oxana B. Kazakova*, Natalya I. Medvedeva, Irina E. Smirnova, Tatyana V. Lopatina and Alexander V. Veselovsky

Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents

Volume:16
Samir Y. Abbas*, Marwa A. M. Sh. El-Sharief, Reem A. K. Al-Harbi, Eman W. El-Gammal and Ahmed M. Sh. El-Sharief

Chemical Properties and Therapeutic Potential of Citral, a Monoterpene Isolated from Lemongrass

Volume:16
Sandeep Sharma, Jeena Gupta*, Shagufta Habib and Debasis Sahu

Benzazole Substituted Iminocoumarins as Potential Antioxidants with Antiproliferative Activity

Volume:16
Nataša Perin, Maja Cindrić, Peter Vervaeke, Sandra Liekens, Tomislav Mašek, Kristina Starčević and Marijana Hranjec*

Synthesized 2-Trifluoromethylquinazolines and Quinazolinones Protect BV2 and N2a Cells against LPS- and H2O2-induced Cytotoxicity

Volume:16
Neeranjini Nallathamby, Chia-Wei Phan, Matej Sova, Luciano Saso and Vikineswary Sabaratnam*

Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis

Volume:16
Alaa M. Abo Alnaja, Thoraya. A. Farghaly*, Heba S. A. El-zahabi and Mohamed R. Shaaban

Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α- glucosidase; Synthesis, Molecular Docking, and Kinetic Study

Volume:15
Tadesse Bekele Tafesse, Ebrahim Saeedian Moghadam, Mohammed Hussen Bule, Mohammad Ali Faramarzi, Mohammad Abdollahi and Mohsen Amini*

Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study

Volume:15
Florentinus D.O. Riswanto, Mira S.A. Rawa, Vikneswaran Murugaiyah, Nurul H. Salin, Enade P. Istyastono, Maywan Hariono and Habibah A. Wahab*

Activity of (-)-Camphene Derivatives Against Mycobacterium tuberculosis in Acidic pH

Volume:15
Hayalla Corrêa de Carvalho, Andressa Lorena Ieque, Tamires Leite Valverde, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, Paula Aline Zanetti Campanerut-Sá, Fábio Vandresen, Luciana Dias Ghiraldi Lopes, Mariana Regina Passos Souza, Nathally Claudiane de Souza Santos, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin Lima Scodro and Rosilene Fressatti Cardoso*

Synthesis, Characterization, Antioxidant Activity of β-diketonates, and Effects of Coordination to Copper(II) ion on Their Activity: DNA, BSA Interactions and Molecular Docking Study

Volume:15
Nenad Joksimović, Jelena Petronijević, Nenad Janković, Marijana Kosanić, Dušan Milivojević, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*

Antitumor Effect of Zwitterions of Imidazolium Derived from L- methionine in BALB/c Mice with Lymphoma L5178Y

Volume:15
Karen C. Vargas-Castro, Ana M. Puebla Pérez, Irma I. Rangel-Salas, Jorge I. Delgado-Saucedo, José B. Pelayo-Vázquez, Elvia Becerra-Martínez, A. Aarón Peregrina-Lucano, Raul R. Quiñonez-Lopez, Gabriela J. Soltero-Reynoso and Sara A. Cortes-Llamas*

N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents

Volume:15
Ana Marzo-Mas, Laura Conesa-Milián, Sam Noppen, Sandra Liekens, Eva Falomir*, Juan Murga, Miguel Carda and J. Alberto Marco

Synthesis and Biological Evaluation of Matrine Derivatives as a Novel Family of Potential Anticancer Agents

Volume:15
Jing Wang, Hang Liu, Xiao-Bin Zhuo, Guang-Ming Ye and Qing-Jie Zhao

Design of Arylsulfonylhydrazones as Potential FabH Inhibitors: Synthesis, Antimicrobial Evaluation and Molecular Docking

Volume:16
Thais Batista Fernandes, Natanael Dante Segretti, Felipe Rebello Lourenço, Thalita Marcílio Cândido, André Rolim Baby, Euzébio Guimarães Barbosa and Roberto Parise-Filho*

A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds

Volume:16
Aleksandra Kładna, Paweł Berczyński, Oya Bozdağ Dündar, Irena Kruk, Beyza Torun and Hassan Y. Aboul-Enein*

Therapeutic Effects of Ziziphus jujuba Mill. Fruit in Traditional and Modern Medicine: A Review

Volume:15
Zahra Sobhani , Sara Nikoofal-Sahlabadi, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami and Amirhossein Sahebkar*

Structural Modifications on CORM-3 Lead to Enhanced Anti-angiogenic Properties Against Triple-negative Breast Cancer Cells

Volume:15
Malamati Kourti*, Jun Cai, Wen Jiang and Andrew D. Westwell

Quantitative Structure Activity/pharmacokinetics Relationship Studies of HIV-1 Protease Inhibitors Using Three Modelling Methods

Volume:15
Dan Han, Jianjun Tan*, Jingrui Men, Chunhua Li and Xiaoyi Zhang

Discovery of Substituted N-(6-Chloro-3-cyano-4-phenyl-4H-chromen-2-yl)- 2-(4-chloro-phenoxy)-acetamide for Biphasic Anticancer and Anticonvulsant Activities

Volume:15
Divya Chauhan*, Syed Riaz Hashim, Priyanka Rani, Sushil Kumar, Navratan Shrimal, Divya Shastri and Vinit Raj

Synthesis and Evaluation of Aryl Substituted Propyl Piperazines for Potential Atypical Antipsychotic Activity

Volume:15
Shalu Singh, Alka Bali* and Tania Peshin

Investigation of Binding Characteristics of Phosphoinositide-dependent Kinase-1 (PDK1) Co-crystallized Ligands Through Virtual Pharmacophore Modeling Leading to Novel anti – PDK1 Hits

Volume:15
Iman A. Mansi*, Mahmoud A. Al-Sha`er*, Nizar M. Mhaidat, Mutasem O. Taha and Rand Shahin

Structure-Based Design, Synthesis, Biological Evaluation and Molecular Docking Study of 4-Hydroxy-N'-methylenebenzohydrazide Derivatives Acting as Tyrosinase Inhibitors as Potentiate Anti-Melanogenesis Activities

Volume:15
Aida Iraji, Mahsima Khoshneviszadeh, Pegah Bakhshizadeh, Najmeh Edraki* and Mehdi Khoshneviszadeh

Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies

Volume:15
Riham M. Bokhtia, Siva S. Panda*, Adel S. Girgis, Hitesh H. Honkanadavar, Tarek S. Ibrahim, Amany M. M. Al-Mahmoudy, Riham F. George, Mona T. Kashef, Walid Fayad, Rajeev Sakhuja and Eatedal H. Abdel-Aal

Improvement of the Anticancer Activity of Chlorambucil and Ibuprofen via Calix[4]arene Conjugates

Volume:15
Luis D. Pedro-Hernández, Ulises Organista-Mateos, Luis Isaac Allende-Alarcón, Elena Martínez-Klimova*, Teresa Ramírez-Ápan and Marcos Martínez-García

Synthetic Dihydropyridines as Novel Antiacanthamoebic Agents

Volume:15
Ayaz Anwar*, Ruqaiyyah Siddiqui, Abdul Hameed, Muhammad Raza Shah and Naveed Ahmed Khan

The Antioxidant, Anticarcinogenic and Antimicrobial Properties of Verbascum thapsus L.

Volume:15
Saman Mahdavi*, Morteza Amiradalat, Marzieh Babashpour, Hosein Sheikhlooei and Mohammad Miransari

ROS Inhibitory Activity and Cytotoxicity Evaluation of Benzoyl, Acetyl, Alkyl Ester, and Sulfonate Ester Substituted Coumarin Derivatives

Volume:15
Uzma Salar, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Farwa Naqvi, Shakil Ahmed, Erum Iqbal, Farman Ali, Kanwal and Shahnaz Perveen