Medicinal Chemistry

Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
(Greece)

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

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Articles Ahead of Print

Design, Synthesis, and Pharmacokinetic Evaluation of O-Carbamoyl Tizoxanide Prodrugs

Volume:16
Xi He, Wenjun Hu, Fanhua Meng and Xingzhou Li*

Synthesis, Cytotoxicity, Anti-migration and Anti-invasion Activity of Diphyllin Heterocyclic Derivatives

Volume:17
Weidong Shen, Haijiao Chen, Miaomiao Wu, Ting Zhang, Li Zhu and Yu Zhao*

Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Volume:16
Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco

Site-directed Fragnomics and MD Simulations Approaches to Identify Interleukin-2 Inhibitors

Volume:16
Ruqaiya Khalil, Saman Usmani, Mohammad Nur-e-Alam, Sarfaraz Ahmed and Zaheer Ul-Haq*

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Volume:16
Vitor F. Ferreira, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva*

Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

Volume:16
Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada*

Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Volume:16
Giada Righetti, Michele Tonelli, Paola Fossa and Elena Cichero*

Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

Volume:16
Altannavch Nyamsambuu, Ashfaque Ahmed, Farjana Yeasmin Khusbu, Sarangerel Oidovsambuu, Md. Asaduzzaman Khan, Xi Zhou, Jun-jiang Fu and Han-Chun Chen*

Synthesis and Clinical Development of Palbociclib: An overview

Volume:17
Debabrata Konar, Saurabh Maru, Subhabrata Kar and Kapil Kumar*

Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

Volume:16
Papagiouvannis Georgios*, Theodosis-Nobelos Panagiotis, Kourounakis N. Panos and Rekka A. Eleni

Antidiabetic and Antioxidative Properties of Novel Zn(II)-cinnamic Acid Complex

Volume:16
Chika I. Chukwuma*, Samson S. Mashele and Shasank S. Swain

Exploring the Molecular Mechanisms of 17β-HSD5-induced Carcinogenicity of Catha edulis via Molecular Modeling Approach

Volume:16
Maria Saeed, Sajda Ashraf, Rashad Alsanosi, Hassan A. Alhazmi, Mohammed AlBratty, Asim Najmi, Asaad Khalid and Zaheer ul Haq*

Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship

Volume:16
M. del Carmen Salazar-López, J. Alberto Guevara-Salazar*, Mónica G. Arellano-Mendoza, Hugo A. Jiménez-Vázquez, Adriana Benavides and Delia Quintana-Zavala

Synthesis and biological evaluation of 4-aminoantipyrine analogues

Volume:16
Houwei Ren, Premnath Dhanaraj, Israel V M V Enoch*, Mosae Selvakumar Paulraj and Indiraleka M

Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

Volume:16
Reema Abu Khalaf*, Haya Abu Jarad, Tariq Al-Qirim and Dima Sabbah

Synthesis, Characterization and Biological Studies of Organoselenium trans-Palladium(II) Complexes

Volume:16
Ivana Raković, Jovana Bogojeski*, Katarina Mladenović, Angelina Petrović, Vera Divac, Kristina Mihailović, Biljana Popovska Jovicić, Marina Kostić, Predrag Canović, Nevena Milivojević, Marko Zivanović and Ivana Radojević

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer

Volume:16
Jamshed Iqbal*, Ayesha Basharat, Sehrish Bano, Syed Mobasher Ali Abid, Julie Pelletier and Jean Sévigny

New Oxazolidines Inhibit the Secretion of IFN-γ and IL-17 by PBMCS from Moderate to Severe Asthmatic Patients

Volume:16
Renata Virgínia Cavalcanti Santos*, Eudes Gustavo Constantino Cunha, Gabriela Souto Vieira de Mello, José Ângelo Rizzo, Jamerson Ferreira de Oliveira, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta and Moacyr Jesus Barreto de Melo Rêgo

Design, Synthesis, and Anti-Neuroinflammatory Activity of Amide- Containing Dithiolethiones

Volume:16
Karrington Craig, Paula Avila and Dennis A. Brown*

Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects

Volume:16
Syed Nasir Abbas Bukhari*, Nasser Hadal Alotaibi, Waqas Ahmad, Khalid Saad Alharbi, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Muhammad Masood Ahmad, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja and Muhammad Ajaz Hussain

Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Volume:16
Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi and Mubashir Hussain Masoodi*

Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives

Volume:16
Digamber S. Pawar, Vasant V. Chabukswar*, Savita R. Tapase, Kisan M. Kodam, Anurudhha Chabukswar, Pravin B. Adhav, Balasaheb B. Diwate, Sunita Salunke Gawali, Sabrina Dallavalle and Swati C. Jagdale

Features, Pharmacological Chemistry, Molecular Mechanism and Health Benefits of Lemon

Volume:16
Nitika Singh, Nagesndra Sastry Yarla, Nikhat Jamal Siddiqi, Maria de Lourdes Pereira and Bechan Sharma*

Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives

Volume:16
Kai-Xia Zhang, Xi-Jing Qian, Wei-Zheng, Meng-Cheng Cai, Ying Ma, Da-Zhi Zhang, Shi-Chong Yu, Qing-Guo Meng and Yong-Sheng Jin*

Indane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies

Volume:16
Asma Mukhtar, Shazia Shah, Kanwal, Shehryar Hameed, Khalid Mohammed Khan*, Shahid Ullah Khan, Sumera Zaib, Jamshed Iqbal and Shahnaz Parveen

Structure-Activity Relationship Study of an Alkynylphosphonate and Vynilphosphonate Analogues of Calcitriol

Volume:16
Silvina Mariela Grioli, Eliana Noelia Alonso, Evangelina Mascaró, Santiago Armando Stabile, María Julia Ferronato, Mario Alfredo Quevedo, Gabriel Radivoy, María Marta Facchinetti, Cristian Alejandro Vitale and Alejandro Carlos Curino*

Novel Coumarin Containing Dithiocarbamate Derivatives as Potent α- Glucosidase Inhibitors for Management of Type 2 Diabetes

Volume:16
Marjan Mollazadeh, Maryam Mohammadi-Khanaposhtani, Yousef Valizadeh, Afsaneh Zonouzi, Mohammad Ali Faramarzi, Mitra Kiani, Mahmood Biglar, Bagher Larijani, Haleh Hamedifar , Mohammad Mahdavi * and Mir Hamed Hajimiri

Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

Volume:16
Wei-Wei Ni, Hai-Lian Fang, Ya-Xi Ye, Wei-Yi Li, Li Liu, Zi-Juan Fu, Dawalamu, Wen-Yan Zhu, Ke Li, Fang Li, Xia Zou, Hui Ouyang, Zhu-Ping Xiao and Hai-Liang Zhu*

Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines

Volume:16
Délis Galvão Guimarães, Arlan de Assis Gonsalves, Larissa Araújo Rolim, Edigênia Cavalcante Araújo, Victória Laysna dos Anjos Santos, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Marcília Pinheiro da Costa, Claudia Pessoa, Marília Oliveira Fonseca Goulart, Thaissa Lucio Silva, Danyelle Cândido Santos and Cleônia Roberta Melo Araújo*

In silico Study to Evaluate the Antiviral Activity of Novel Structures against 3C-like Protease of Novel Coronavirus (COVID-19) and SARSCoV

Volume:16
Kiran Chunduru*, Runali Sankhe*, Farmiza Begum, Nalini Sodum, Nitesh Kumar, Anoop Kishore, Rekha R. Shenoy, C. Mallikarjuna Rao and Kavitha Saravu

Xanthone: A Promising Antimycobacterial Scaffold

Volume:16
Tilal Elsaman, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla and Magdi Awadalla Mohamed*

Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies

Volume:16
Mahboob Ali, Momin Khan, Khair Zaman, Abdul Wadood, Maryam Iqbal, Aftab Alam, Sana Shah, Ashfaq Ur Rehman, Muhammad Yousaf, Rafaila Rafique and Khalid Mohammed Khan*

Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study

Volume:16
Uma Krithika, Prabitha P, Subhankar P. Mandal, Yuvaraj S, Priya D, Ashish D Wadhwani and B. R. Prashantha Kumar*

Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies

Volume:16
Taibi Ben Hadda, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan, Hsaine Zgou, Abdur Rauf, Yahia Nasser Mabkhot, Brahim Bennani, Dalia R. Emam, Nabila Abdelshafy Kheder, Abdulrhman Asayari, Abdullatif Bin Muhsinah and Aneela Maalik*

Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4- Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro

Volume:16
Lucas da Silva Santos, Matheus Fillipe Langanke de Carvalho, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Julio César Dias Lopes, Fernando de Pilla Varotti, Rossimiriam Pereira de Freitas and Rosemeire Brondi Alves*

Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity

Volume:16
Vesna Milovanović, Zorica D. Petrović*, Slađana Novaković, Goran A. Bogdanović, Dušica Simijonović, Milan Mladenović, Jovica Branković and Vladimir P. Petrović

Synthesis and Anticancer Activity of Thiadiazole Containing Thiourea, Benzothiazole and Imidazo[2,1-b][1,3,4]thiadiazole Scaffolds

Volume:16
Stephen Paul Avvaru, Malleshappa N. Noolvi*, Uttam A More, Sudipta Chakraborty, Ashutosh Dash, Tejraj M Aminabhavi, Kumar P Narayan and Vishnu Sutariya

Structure-Based Virtual Screening of New Benzoic Acid Derivatives as Trypanosoma cruzi Trans-sialidase Inhibitors

Volume:16
Lenci Karina Vázquez-Jiménez, Alma Delia Paz-González, Alfredo Juárez-Saldivar, María Laura Uhrig, Rosalía Agusti, Alicia Reyes-Arellano, Benjamín Nogueda-Torres and Gildardo Rivera*

Curcumin-based Antioxidant and Glycohydrolase Inhibitor Compounds: Synthesis and In Vitro Appraisal of the Dual Activity Against Diabetes

Volume:16
Sajjad Esmaeili, Nazanin Ghobadi, Donya Nazari, Alireza Pourhossein, Hassan Rasouli, Hadi Adibi and Reza Khodarahmi*

Synthesis of thiazolyl-N-phenylmorpholine Derivatives and their Biological Activities

Volume:16
Amerah M. Al-Soliemy, Thoraya A. Farghaly, Eman M. H. Abbas, Mohamed R. Shaaban*, Mohie E. M. Zayed and Tarek B. A. El-Naggar

Novel Aminopyrazole Tagged Hydrazones as Anti-Tubercular Agents: Synthesis and Molecular Docking Studies

Volume:16
Thatavarthi Padmini, Darna Bhikshapathi, Kandagatla Suresh, Ravindra Kulkarni* and Bigala Raj Kamal

Synthesis and Cytotoxic Activity of Novel Mono- and Bis-Indole Derivatives: Analogues of Marine Alkaloid Nortopsentin

Volume:16
Mona Monir Kamel, Mohamed Kamal Abdel-hameid, Hala Bakr El-Nassan* and Eman Adel El-Khouly

Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation

Volume:16
Tran Khac Vu*, Nguyen Thi Thanh, Nguyen Van Minh, Nguyen Huong Linh, Nguyen Thi Phương Thao, Trương Thuc Bao Nguyen, Doan Thi Hien, Luu Van Chinh, Ta Hong Duc, Lai Duc Anh and Pham-The Hai

Synthesis, Molecular Docking Studies and Antibacterial Activities of Novel Monocationic Indole-benzimidazole Derivatives

Volume:16
Zeynep Ates-Alagoz*, Mehmet Murat Kisla, Hakan Goker and Sulhiye Yildiz

2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Antiglioma Activities in C6 and GL261 Cells

Volume:16
Alana de Vasconcelos, Ana Júlia Zulian Boeira, Bruna Bento Drawanz, Nathalia Stark Pedra, Natália Pontes Bona, Francieli Moro Stefanello and Wilson Cunico*

In silico Studies on the Interaction Between Bioactive Ligands and DPPIV: Insights on Potential Candidates for the Treatment of type 2 Diabetes Mellitus

Volume:16
Michelle Cristiane Melo Reis Martins, Simone Queiroz Pantaleao, Michell de Oliveira Almeida, Karen Cacilda Weber and Kathia Maria Honorio*

Synthesis and Antioxidant Activity of New Selenium-Containing Quinolines

Volume:16
Benedetta Bocchini, Bruna Goldani, Fernanda S.S. Sousa, Paloma T. Birmann, Cesar A. Brüning, Eder J. Lenardão, Claudio Santi, Lucielli Savegnago and Diego Alves*

The Interaction of Schistosoma Japonicum Glutathione Transferase with Cibacron Blue 3GA and its Fragments

Volume:16
Michalis Platis, Dimitrios Vlachakis, Ahmed Ibrahim Foudah, Magdy Mohamed Muharram, Mohamed Hamed Alqarni, Anastassios C. Papageorgiou and Nikolaos E. Labrou*

Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Volume:16
Archana Awasthi, Mantripragada Bhagavan Raju and Md Azizur Rahman*

Withdrawal Notice: The Design, Synthesis, Pharmacokinetic and Pharmacodynamic Evaluation of Acyloxyalkyl-substituted T705 Prodrugs

Volume:15
Xingzhou Li, Tianhong Zhang and Wu Zhong

New Approaches in Sensing and Targeting Bacterial rRNA A-site

Volume:16
Preethi Parameswaran, Nihar Ranjan* and S.J.S. Flora*

Synthesis and Structure-activity Relationship of Aminoarylthiazole Derivatives as Potential Potentiators of the Chloride Transport Defect in Cystic Fibrosis

Volume:16
Nara Liessi, Emanuela Pesce, Annalisa Salis, Gianluca Damonte, Bruno Tasso, Elena Cichero, Nicoletta Pedemonte and Enrico Millo*

Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives

Volume:16
Camila Capelini, Vitória R. F. Câmara, José D. Figueroa Villar, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Policarpo A. Sales Junior, Silvane M. F. Murta, Thais B. Couto, Maria Cristina S. Lourenço, James L. Wardell, John N. Low, Edson F. da Silva and Samir A. Carvalho*

Elucidating Molecular Interactions of Ten Natural Compounds Targeting E6 HPV High Risk Oncoproteins Using Microsecond Molecular Dynamics Simulations

Volume:16
Thuluz Meza-Menchaca, Marcela Lizano-Soberón, Angel Trigos, Rossana C. Zepeda, Manuel E. Medina and Rodrigo Galindo-Murillo*

A Comprehension into Target Binding and Spatial Fingerprints of Noscapinoid Analogues as Inhibitors of Tubulin

Volume:16
Seema Mandavi, Renu Bhatt, Sant Kumar Verma, Laxmi Banjare, Amit Dubey, Suresh Thareja and Akhlesh Kumar Jain*

Molecular Docking Studies Reveal Rhein from rhubarb (Rheum rhabarbarum) as a Putative Inhibitor of ATP-binding Cassette Super Family G member 2

Volume:16
Muhammad Saad Khan, Bareera Mehmood, Qudsia Yousafi, Shabana Bibi, Sahar Fazal, Shahzad Saleem, Muhammad Wasim Sajid, Awais Ihsan, Muhammad Azhar and Mohammad Amjad Kamal*

Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents

Volume:16
Samir Y. Abbas*, Marwa A. M. Sh. El-Sharief, Reem A. K. Al-Harbi, Eman W. El-Gammal and Ahmed M. Sh. El-Sharief

Synthesized 2-Trifluoromethylquinazolines and Quinazolinones Protect BV2 and N2a Cells against LPS- and H2O2-induced Cytotoxicity

Volume:16
Neeranjini Nallathamby, Chia-Wei Phan, Matej Sova, Luciano Saso and Vikineswary Sabaratnam*

Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis

Volume:16
Alaa M. Abo Alnaja, Thoraya. A. Farghaly*, Heba S. A. El-zahabi and Mohamed R. Shaaban

Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α- glucosidase; Synthesis, Molecular Docking, and Kinetic Study

Volume:15
Tadesse Bekele Tafesse, Ebrahim Saeedian Moghadam, Mohammed Hussen Bule, Mohammad Ali Faramarzi, Mohammad Abdollahi and Mohsen Amini*

Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study

Volume:15
Florentinus D.O. Riswanto, Mira S.A. Rawa, Vikneswaran Murugaiyah, Nurul H. Salin, Enade P. Istyastono, Maywan Hariono and Habibah A. Wahab*

Activity of (-)-Camphene Derivatives Against Mycobacterium tuberculosis in Acidic pH

Volume:15
Hayalla Corrêa de Carvalho, Andressa Lorena Ieque, Tamires Leite Valverde, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, Paula Aline Zanetti Campanerut-Sá, Fábio Vandresen, Luciana Dias Ghiraldi Lopes, Mariana Regina Passos Souza, Nathally Claudiane de Souza Santos, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin Lima Scodro and Rosilene Fressatti Cardoso*

Synthesis, Characterization, Antioxidant Activity of β-diketonates, and Effects of Coordination to Copper(II) ion on Their Activity: DNA, BSA Interactions and Molecular Docking Study

Volume:15
Nenad Joksimović, Jelena Petronijević, Nenad Janković, Marijana Kosanić, Dušan Milivojević, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*

Synthesis and Biological Evaluation of Matrine Derivatives as a Novel Family of Potential Anticancer Agents

Volume:15
Jing Wang, Hang Liu, Xiao-Bin Zhuo, Guang-Ming Ye and Qing-Jie Zhao

Design of Arylsulfonylhydrazones as Potential FabH Inhibitors: Synthesis, Antimicrobial Evaluation and Molecular Docking

Volume:16
Thais Batista Fernandes, Natanael Dante Segretti, Felipe Rebello Lourenço, Thalita Marcílio Cândido, André Rolim Baby, Euzébio Guimarães Barbosa and Roberto Parise-Filho*

A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds

Volume:16
Aleksandra Kładna, Paweł Berczyński, Oya Bozdağ Dündar, Irena Kruk, Beyza Torun and Hassan Y. Aboul-Enein*

Discovery of Substituted N-(6-Chloro-3-cyano-4-phenyl-4H-chromen-2-yl)- 2-(4-chloro-phenoxy)-acetamide for Biphasic Anticancer and Anticonvulsant Activities

Volume:15
Divya Chauhan*, Syed Riaz Hashim, Priyanka Rani, Sushil Kumar, Navratan Shrimal, Divya Shastri and Vinit Raj

Synthesis, Antimicrobial Evaluation and Docking Study of Novel 3,5- Disubstituted-2-Isoxazoline and 1,3,5-Trisubstituted-2-Pyrazoline Derivatives

Volume:15
Ahmed Hussein Ismail, Ahmed Mutanabbi Abdula, Ivan H.R. Tomi, Ali Hussein R. Al-Daraji and Younis Baqi*