Medicinal Chemistry

Discovery of Substituted N-(6-Chloro-3-cyano-4-phenyl-4H-chromen-2-yl)- 2-(4-chloro-phenoxy)-acetamide for Biphasic Anticancer and Anticonvulsant Activities

Volume: 17   Issue: 3
Pp: 203-215
Divya Chauhan*, Syad Riaz Hashim, Prinka Rani, Sushil Kumar, Navratan Shrimal, Divya Shastri and Vinit Raj*
DOI: 10.2174/1573406415666191206101617

Molecular Docking Studies Reveal Rhein from rhubarb (Rheum rhabarbarum) as a Putative Inhibitor of ATP-binding Cassette Super Family G member 2

Volume: 17   Issue: 3
Pp: 273-288
Muhammad Saad Khan, Bareera Mehmood, Qudsia Yousafi, Shabana Bibi, Sahar Fazal, Shahzad Saleem, Muhammad Wasim Sajid, Awais Ihsan, Muhammad Azhar* and Mohammad Amjad Kamal*
DOI: 10.2174/1573406416666191219143232

In silico Studies on the Interaction Between Bioactive Ligands and DPPIV: Insights on Potential Candidates for the Treatment of type 2 Diabetes Mellitus

Volume: 17   Issue: 3
Pp: 247-263
Michelle C.M.R. Martins, Simone Q. Pantaleao, Michell de Oliveira Almeida, Karen C. Weber and Kathia M. Honorio*
DOI: 10.2174/1573406416666200129151256

Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study

Volume: 17   Issue: 3
Pp: 216-229
Uma Krithika, P. Prabitha, Subhankar P. Mandal, S. Yuvaraj, D. Priya, Ashish D. Wadhwani and B.R. Prashantha Kumar*
DOI: 10.2174/1573406416666200610191002

Structure-Activity Relationship Study of an Alkynylphosphonate and Vynilphosphonate Analogues of Calcitriol

Volume: 17   Issue: 3
Pp: 230-246
Silvina M. Grioli, Eliana N. Alonso, Evangelina Mascaró, Santiago A. Stabile, María J. Ferronato, Mario A. Quevedo, Gabriel Radivoy, María M. Facchinetti, Cristian A. Vitale and Alejandro C. Curino*
DOI: 10.2174/1573406416999200818145115

Novel Coumarin Containing Dithiocarbamate Derivatives as Potent α- Glucosidase Inhibitors for Management of Type 2 Diabetes

Volume: 17   Issue: 3
Pp: 264-272
Marjan Mollazadeh, Maryam Mohammadi-Khanaposhtani, Yousef Valizadeh, Afsaneh Zonouzi, Mohammad A. Faramarzi, Mitra Kiani, Mahmood Biglar, Bagher Larijani, Haleh Hamedifar , Mohammad Mahdavi * and Mir Hamed Hajimiri*
DOI: 10.2174/1573406416666200826101205

Features, Pharmacological Chemistry, Molecular Mechanism and Health Benefits of Lemon

Volume: 17   Issue: 3
Pp: 187-202
Nitika Singh, Nagendra Sastry Yarla, Nikhat Jamal Siddiqi, Maria de Lourdes Pereira and Bechan Sharma*
DOI: 10.2174/1573406416666200909104050

New Oxazolidines Inhibit the Secretion of IFN-γ and IL-17 by PBMCS from Moderate to Severe Asthmatic Patients

Volume: 17   Issue: 3
Pp: 289-297
Renata Virgínia Cavalcanti Santos, Eudes Gustavo Constantino Cunha, Gabriela Souto Vieira de Mello, José Ângelo Rizzo, Jamerson Ferreira de Oliveira, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta and Moacyr Jesus Barreto de Melo Rêgo*
DOI: 10.2174/1573406416666200910151950

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy open access plus

Volume: 17   Issue: 2
Pp: 97-120
Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*
DOI: 10.2174/1573406416666191227120425

The Introduction of Hydrazone, Hydrazide, or Azepane Moieties to the Triterpenoid Core Enhances an Activity Against M. tuberculosis

Volume: 17   Issue: 2
Pp: 134-145
Oxana B. Kazakova*, Natalya I. Medvedeva, Irina E. Smirnova, Tatyana V. Lopatina and Alexander V. Veselovsky
DOI: 10.2174/1573406416666200115161700

Molecular Docking and Dynamics Simulation Analysis of Thymoquinone and Thymol Compounds from Nigella sativa L. that Inhibit Cag A and Vac A Oncoprotein of Helicobacter pylori: Probable Treatment of H. pylori Infections

Volume: 17   Issue: 2
Pp: 146-157
Heena Tabassum and Iffat Zareen Ahmad*
DOI: 10.2174/1573406416666200302113729

Synthesis, Molecular Docking and Biological Evaluation of Novel Flavone Derivatives as Potential Anticancer Agents Targeting Akt

Volume: 17   Issue: 2
Pp: 158-170
Heba M. Abo-Salem, Abdullah A Gibriel*, Mohamed E. El Awady and Adel H. Mandour
DOI: 10.2174/1573406416666200306115035

Synthesis, Molecular Modeling of Novel Substituted Pyridazinones and their Vasorelaxant Activities

Volume: 17   Issue: 2
Pp: 171-186
Magda M.F. Ismail, Dalia H.S. Soliman*, Mona H. Abd Elmoniem and Ghehad A.R. Abdel Jaleel
DOI: 10.2174/1573406416666200327191100

Synthesis and Erythroid Induction Activity of New Thiourea Derivatives

Volume: 17   Issue: 2
Pp: 121-133
Hina Siddiqui*, Sarah Shafi, Hamad Ali and Syed Ghulam Musharraf
DOI: 10.2174/1573406416666200514085623

Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies

Volume: 17   Issue: 1
Pp: 71-84
Riham M. Bokhtia, Siva S. Panda*, Adel S. Girgis, Hitesh H. Honkanadavar, Tarek S. Ibrahim, Riham F. George, Mona T. Kashef, Walid Fayad, Rajeev Sakhuja, Eatedal H. Abdel-Aal and Amany M. M. Al-Mahmoudy
DOI: 10.2174/1573406415666190904143852

N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents

Volume: 17   Issue: 1
Pp: 21-32
Ana Marzo-Mas, Laura Conesa-Milián, Sam Noppen, Sandra Liekens, Eva Falomir*, Juan Murga, Miguel Carda and Juan A. Marco
DOI: 10.2174/1573406415666191203112406

Antitumor Effect of Zwitterions of Imidazolium Derived from L-methionine in BALB/c Mice with Lymphoma L5178Y

Volume: 17   Issue: 1
Pp: 33-39
Karen C. Vargas-Castro, Ana M. Puebla Pérez, Irma I. Rangel-Salas, Jorge I. Delgado-Saucedo, José B. Pelayo-Vázquez, Elvia Becerra-Martínez, Alejandro A. Peregrina-Lucano, Raul R. Quiñonez-Lopez, Gabriela J. Soltero-Reynoso and Sara A. Cortes-Llamas*
DOI: 10.2174/1573406415666191206093754

Structural Modifications on CORM-3 Lead to Enhanced Anti-angiogenic Properties Against Triple-negative Breast Cancer Cells

Volume: 17   Issue: 1
Pp: 40-59
Malamati Kourti*, Jun Cai, Wen Jiang and Andrew D. Westwell
DOI: 10.2174/1573406415666191206102452

Benzazole Substituted Iminocoumarins as Potential Antioxidants with Antiproliferative Activity

Volume: 17   Issue: 1
Pp: 13-20
Nataša Perin, Maja Cindrić, Peter Vervaeke, Sandra Liekens, Tomislav Mašek, Kristina Starčević* and Marijana Hranjec*
DOI: 10.2174/1573406416666191218101427

Chemical Properties and Therapeutic Potential of Citral, a Monoterpene Isolated from Lemongrass

Volume: 17   Issue: 1
Pp: 2-12
Sandeep Sharma, Shagufta Habib, Debasis Sahu and Jeena Gupta*
DOI: 10.2174/1573406416666191227111106

Synthesis of new Enrofloxacin Derivatives as Potential Antibiofilm Drugs Against Staphylococcus Aureus and Klebsiella Pneumoniae

Volume: 17   Issue: 1
Pp: 85-96
Hina Siddiqui *, Haroon M. Haniffa, Ayaz Ahmed and Muhammad I. Choudhary*
DOI: 10.2174/1573406416666200402151705

DFT Studies of Distinct Anilines with p-Hydroxycinnamic Acids for Antioxidant Profile

Volume: 17   Issue: 1
Pp: 60-70
Ch. Ravi S. Kumar*, Anjali Jha and Sri Deepthi
DOI: 10.2174/1573406416666200506085152

Foreword promotion: free to download

Volume: 17   Issue: 1
Pp: 1-1
Dimitra Hadjipavlou-Litina
DOI: 10.2174/157340641701201204091649

Synthesis and Clinical Development of Palbociclib: An overview

Volume: 17   Issue:
Pp: 1-27
Debabrata Konar, Saurabh Maru, Subhabrata Kar and Kapil Kumar*
DOI: 10.2174/1573406417666201204161243

Synthesis, Biological Profile, and Molecular Docking of Some New BisImidazole Fused Templates and Investigation of Their Cytotoxic Potential as Anti-tubercular and/or Anticancer Prototypes

Volume: 17   Issue:
Pp: 1-16
Refaie M. Kassab, Sobhi M. Gomha, Zeinab A. Muhammad* and Ahmed S. El-khouly
DOI: 10.2174/1573406417666201208121458

Elucidating the Disparate Inhibitory Mechanisms of Novel 1-Heteroaryl1,3-Propanediamine Derivatives and Maraviroc towards C-C Chemokine Receptor 5: Insights for Structural Modifications in HIV-1 Drug Discovery

Volume: 17   Issue:
Pp: 1-14
Patrick Appiah-Kubi, Fisayo Andrew Olotu and Mahmoud E. S. Soliman*
DOI: 10.2174/1573406417666201208122110

A Combined approach of Pharmacophore Modeling, QSAR Study, Molecular Docking and in silico ADME/Tox prediction of 4-Arylthio & 4- Aryloxy-3- Iodopyridine-2(1H)-one analogs to identify potential Reverse Transcriptase inhibitor: Anti-HIV agents

Volume: 17   Issue:
Pp: 1-39
Debadash Panigrahi*, Amiyakanta Mishra, Susanta Kumar Sahu, Mohd. Afzal Azam and C.M. Vyshaag
DOI: 10.2174/1573406417666201214100822

In vitro, in vivo and in silico Antihyperglycemic Activity of Some Semi-synthetic Phytol Derivatives.

Volume: 17   Issue:
Pp: 1-8
Harish C. Upadhyay, Akansha Mishra, Jyotsana Pandey, Pooja Sharma, Akhilesh K. Tamrakar, Arvind K. Srivastava, Feroz Khan and Santosh K. Srivastava*
DOI: 10.2174/1573406417666201216124018

Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Plausible lead for Alzheimer’s Disease.

Volume: 17   Issue:
Pp: 1-14
Priti Jain*, Pankaj K Wadhwa and Hemant R Jadhav
DOI: 10.2174/1573406417666201221155452

Synthesis, Cytotoxicity, Anti-migration and Anti-invasion Activity of Diphyllin Heterocyclic Derivatives

Volume: 17   Issue:
Pp: 1-9
Weidong Shen, Haijiao Chen, Miaomiao Wu, Ting Zhang, Li Zhu and Yu Zhao*
DOI: 10.2174/1573406417666201221160220

Synthesis, Cytotoxicity, ADMET and Molecular Docking Studies of Some Quinoline-Pyrimidine Hybrid Compounds: 3-(2-Amino-6-arylpyrimidin-4- yl)-4-hydroxy-1-methylquinolin-2(1H)-ones

Volume: 17   Issue:
Pp: 1-1
Duong Ngoc Toan*, Nguyen Dinh Thanh*, Mai Xuan Truong and Dinh Thuy Van
DOI: 10.2174/1573406417666201230092615

Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies

Volume: 17   Issue:
Pp: 1-1
Thaise Martins, Vera L.M. Silva, Artur M.S. Silva, José L.F.C. Lima, Eduarda Fernandes* and Daniela Ribeiro*
DOI: 10.2174/1573406417666201230093207

Piroxicam Analogs: Design, Synthesis, Docking Study and Biological Evaluation as Promising Anti-HIV-1 agents

Volume: 17   Issue:
Pp: 1-1
Ali Imani, Sepehr Soleymani, Rouhollah Vahabpour, Zahra Hajimahdi* and Afshin Zarghi*
DOI: 10.2174/1573406417666210125141639

ROS Inhibitory Activity and Cytotoxicity Evaluation of Benzoyl, Acetyl, Alkyl Ester, and Sulfonate Ester Substituted Coumarin Derivatives

Volume: 16   Issue: 8
Pp: 1099-1111
Uzma Salar, Khalid M. Khan*, Almas Jabeen, Aisha Faheem, Farwa Naqvi, Shakil Ahmed, Erum Iqbal, Farman Ali, Kanwal and Shahnaz Perveen
DOI: 10.2174/1573406415666190826153001

New Insights Towards 1,4-Benzodiazepines from Curcumin. Design, Synthesis and Antimicrobial Activities

Volume: 16   Issue: 8
Pp: 1112-1123
Othman Hamed*, Oswa Fares, Shaima Taleeb, Ghaleb Adwan, Haythem Saadeh, Shehdeh Jodeh and Manuel Algarra
DOI: 10.2174/1573406415666190826160251

Therapeutic Effects of Ziziphus jujuba Mill. Fruit in Traditional and Modern Medicine: A Review

Volume: 16   Issue: 8
Pp: 1069-1088
Zahra Sobhani , Sara Nikoofal-Sahlabadi, Mohammad S. Amiri, Mahin Ramezani, Seyed A. Emami* and Amirhossein Sahebkar*
DOI: 10.2174/1573406415666191031143553

An Increasing Role of Polyphenols as Novel Therapeutics for Alzheimer’s: A Review

Volume: 16   Issue: 8
Pp: 1007-1021
Nasiara Karim, Haroon Khan*, Imran Khan, Ouyang Guo, Eduardo Sobarzo-Sánchez, Luca Rastrelli and Mohammad A. Kamal
DOI: 10.2174/1573406415666191105154407

NMR: From Molecular Mechanism to its Application in Medical Care

Volume: 16   Issue: 8
Pp: 1089-1098
Zhenhong Zhang, Xiaohong Meng, Wei Cui, Syed S. Ahmad, Mohammad A. Kamal and Jinguo Zhang*
DOI: 10.2174/1573406415666191111141630

Tyramine Derivatives as Potent Therapeutics for Type 2 Diabetes: Synthesis and In Vitro Inhibition of α-Glucosidase Enzyme

Volume: 16   Issue: 8
Pp: 1124-1135
Muhammad A. Bashir, Kulsoom Javaid, Muniza Shaikh, Muhammad I. Choudhary* and Hina Siddiqui*
DOI: 10.2174/1573406416666200128114422

Herbal Medicine for Glioblastoma: Current and Future Prospects

Volume: 16   Issue: 8
Pp: 1022-1043
Imran Khan, Sadaf Mahfooz and Mustafa A. Hatiboglu*
DOI: 10.2174/1573406416666200130100833

The Valuable Impacts of Halophytic Genus Suaeda; Nutritional, Chemical, and Biological Values

Volume: 16   Issue: 8
Pp: 1044-1057
Hamdoon A. Mohammed*
DOI: 10.2174/1573406416666200224115004

Denouement of Chemicals on Amyotrophic Lateral Sclerosis: Is Green Chemistry the Answer

Volume: 16   Issue: 8
Pp: 1058-1068
Faizana Fayaz, Faheem H. Pottoo, Sadat Shafi, Mushtaq A. Wani, Sharad Wakode* and Anjali Sharma
DOI: 10.2174/1573406416666200413111330

Current views on Medicinal Chemistry versus Green Chemistry for Management of Broad-spectrum Health Issues promotion: free to download

Volume: 16   Issue: 8
Pp: 1005-1006
Syed S. Ahmad and Mohammad A. Kamal
DOI: 10.2174/157340641608201026103030

Acknowledgements to Reviewers promotion: free to download

Volume: 16   Issue: 8
Pp: 1136-1137

DOI: 10.2174/157340641608201026112236

Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated/ N-Tiophosphorylated Tacrine

Volume: 16   Issue: 7
Pp: 947-957
Maja Przybyłowska, Iwona Inkielewicz-Stepniak, Szymon Kowalski, Krystyna Dzierzbicka*, Sebastian Demkowicz and Mateusz Daśko
DOI: 10.2174/1573406415666190716115524

Synthetic Dihydropyridines as Novel Antiacanthamoebic Agents

Volume: 16   Issue: 7
Pp: 841-847
Ayaz Anwar*, Ruqaiyyah Siddiqui, Abdul Hameed, Muhammad R. Shah and Naveed A. Khan
DOI: 10.2174/1573406415666190722113412

Application of Ionic Liquids for the Determination of Lipophilicity Parameters Using TLC Method, and QSRR Analysis for the Antipsychotic Drugs

Volume: 16   Issue: 7
Pp: 848-859
Dominik Mieszkowski, Marcin Koba and Michał P. Marszałł*
DOI: 10.2174/1573406415666190723162959

Investigation of Binding Characteristics of Phosphoinositide-dependent Kinase-1 (PDK1) Co-crystallized Ligands Through Virtual Pharmacophore Modeling Leading to Novel Anti-PDK1 Hits

Volume: 16   Issue: 7
Pp: 860-880
Iman A. Mansi*, Mahmoud A. Al-Sha'er*, Nizar M. Mhaidat, Mutasem O. Taha and Rand Shahin
DOI: 10.2174/1573406415666190724131048

Structure-Based Design, Synthesis, Biological Evaluation and Molecular Docking Study of 4-Hydroxy-N'-methylenebenzohydrazide Derivatives Acting as Tyrosinase Inhibitors with Potentiate Anti-Melanogenesis Activities

Volume: 16   Issue: 7
Pp: 892-902
Aida Iraji, Mahsima Khoshneviszadeh, Pegah Bakhshizadeh, Najmeh Edraki* and Mehdi Khoshneviszadeh*
DOI: 10.2174/1573406415666190724142951

Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities

Volume: 16   Issue: 7
Pp: 881-891
Beatriz C. Marques, Mariana B. Santos, Daiane B. Anselmo, Diego A. Monteiro, Eleni Gomes, Marilia F.C. Saiki, Paula Rahal, Pedro L. Rosalen, Janaina C.O. Sardi and Luis O. Regasini*
DOI: 10.2174/1573406415666190724145158

Design, Synthesis, Antimalarial Activity and Docking Study of 7-Chloro-4- (2-(substituted benzylidene)hydrazineyl)quinolines

Volume: 16   Issue: 7
Pp: 928-937
Jahnabi Kalita, Dipak Chetia and Mithun Rudrapal*
DOI: 10.2174/1573406415666190806154722

Molecular Modeling Studies of Anti-Alzheimer Agents by QSAR, Molecular Docking and Molecular Dynamics Simulations Techniques

Volume: 16   Issue: 7
Pp: 903-927
Rahman Abdizadeh, Farzin Hadizadeh and Tooba Abdizadeh*
DOI: 10.2174/1573406415666190806155619

Novel Benzoxazin-3-one Derivatives: Design, Synthesis, Molecular Modeling, Anti-HIV-1 and Integrase Inhibitory Assay

Volume: 16   Issue: 7
Pp: 938-946
Mahdieh Safakish, Zahra Hajimahdi, Rouhollah Vahabpour, Rezvan Zabihollahi and Afshin Zarghi*
DOI: 10.2174/1573406415666190826161123

Improvement of the Anticancer Activity of Chlorambucil and Ibuprofen via Calix[4]arene Conjugates

Volume: 16   Issue: 7
Pp: 984-990
Luis D. Pedro-Hernández, Ulises Organista-Mateos, Luis I. Allende-Alarcón, Elena Martínez-Klimova*, Teresa Ramírez-Ápan and Marcos Martínez-García
DOI: 10.2174/1573406415666190826162339

The Antioxidant, Anticarcinogenic and Antimicrobial Properties of Verbascum thapsus L.

Volume: 16   Issue: 7
Pp: 991-995
Saman Mahdavi*, Morteza Amiradalat, Marzieh Babashpour, Hosein Sheikhlooei and Mohammad Miransari
DOI: 10.2174/1573406415666190828155951

Design, Synthesis, and Biological Evaluation of 4-amino Substituted 2Hchromen- 2-one Derivatives as an NEDD8 Activating Enzyme Inhibitor in Pancreatic Cancer Cells

Volume: 16   Issue: 7
Pp: 969-983
Lijuan Zhu, Peng Lu, Lei Gong, Cheng Lu, Mengli Li and Yubin Wang*
DOI: 10.2174/1573406416666191227121520

Antidiabetic Activity of Dihydropyrimidine Scaffolds and Structural Insight by Single Crystal X-ray Studies

Volume: 16   Issue: 7
Pp: 996-1003
Keshab M. Bairagi, Nancy S. Younis, Promise M. Emeka, Ekta Sangtani, Rajesh G. Gonnade, Katharigatta N. Venugopala*, Osama I. Alwassil, Hany E. Khalil and Susanta K. Nayak*
DOI: 10.2174/1573406416666191227123048

Design, Synthesis and Antitumor Assessment of Phenylureas Bearing 5-Fluoroindolin-2-one Moiety

Volume: 16   Issue: 7
Pp: 958-968
Yunrui Cai, Tong Chen, Huajian Zhu and Hongbin Zou*
DOI: 10.2174/1573406416666200206123319

Synthesis and Evaluation of Glycyrrhetic Acid-aromatic Hybrids as Anti-inflammatory Agents

Volume: 16   Issue: 6
Pp: 715-723
Zhi Chen, Shi-Chao Chen, Bo Li, Yong-An Yang and Jing Zhang*
DOI: 10.2174/1573406415666190603095502

Synthesis, In vitro α-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives

Volume: 16   Issue: 6
Pp: 724-734
Hayat Ullah, Fazal Rahim, Muhammad Taha*, Raffaqat Hussain, Abdul Wadood, Mohsan Nawaz, Zainul Wahab, Kanwal and Khalid M. Khan
DOI: 10.2174/1573406415666190612150447

2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management

Volume: 16   Issue: 6
Pp: 826-840
Saeed Ullah, Salma Mirza, Uzma Salar, Shafqat Hussain, Kulsoom Javaid, Khalid M. Khan*, Ruqaiya Khalil, Atia-tul-Wahab, Zaheer Ul-Haq, Shahnaz Perveen and Muhammad I. Choudhary
DOI: 10.2174/1573406415666190612153150

Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (Type II)

Volume: 16   Issue: 6
Pp: 735-749
Özgür Yılmaz, Burak Bayer, Hatice Bekçi, Abdullahi I. Uba, Ahmet Cumaoğlu, Kemal Yelekçi and Ş. Güniz Küçükgüzel*
DOI: 10.2174/1573406415666190613162322

Synthesis, Characterization, Antimicrobial Activity and Anticancer of Some New Pyrazolo[1,5-a]pyrimidines and Pyrazolo[5,1-c]1,2,4-triazines

Volume: 16   Issue: 6
Pp: 750-760
Mona A. Hosny, Yasser H. Zaki*, Wafaa A. Mokbel and Abdou O. Abdelhamid*
DOI: 10.2174/1573406415666190620144404

Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

Volume: 16   Issue: 6
Pp: 774-783
Mayara S.S. do Nascimento, Vitória R.F. Câmara, Juliana S. da Costa, Juliana M.C. Barbosa, Alessandra S.M. Lins, Kelly Salomão, Solange L. de Castro, Samir A. Carvalho, Edson F. da Silva and Carlos A.M. Fraga*
DOI: 10.2174/1573406415666190627103013

Kisspeptin and the “Special Relationship” Between Reproduction and Metabolism: A Computational Approach

Volume: 16   Issue: 6
Pp: 796-811
George I. Lambrou and Flora Bacopoulou*
DOI: 10.2174/1573406415666190710182906

Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

Volume: 16   Issue: 6
Pp: 784-795
Krisnna M.A. Alves, Fábio José Bonfim Cardoso, Kathia M. Honorio and Fábio A. de Molfetta*
DOI: 10.2174/1573406415666190712111139

A New Reactive Ketenaminal: Synthesis, Coupling Reaction, Tautomeric Study, Docking and Antimicrobial Evaluation of the Products

Volume: 16   Issue: 6
Pp: 761-773
Huda K. Mahmoud, Hanadi A. Katouah, Marwa F. Harras and Thoraya A. Farghaly*
DOI: 10.2174/1573406415666190716153425

In Silico Design, Synthesis and Evaluation of Novel Series of Benzothiazole- Based Pyrazolidinediones as Potent Hypoglycemic Agents

Volume: 16   Issue: 6
Pp: 812-825
Michelyne Haroun*
DOI: 10.2174/1573406416666191227113716

Design, Synthesis and Biological Evaluation of Anti-tuberculosis Agents based on Bedaquiline Structure

Volume: 16   Issue: 5
Pp: 703-714
Chengjun Wu, Jinghan Luo, Mengtong Wu, Fanzhen Meng, Zhiqiang Cai, Yu Chen* and Tiemin Sun*
DOI: 10.2174/1573406415666190613094433

Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold

Volume: 16   Issue: 5
Pp: 689-702
Saira Afzal, Sumera Zaib, Behzad Jafari, Peter Langer, Joanna Lecka, Jean Sévigny and Jamshed Iqbal*
DOI: 10.2174/1573406415666190614095821

iATP: A Sequence Based Method for Identifying Anti-tubercular Peptides

Volume: 16   Issue: 5
Pp: 620-625
Wei Chen*, Pengmian Feng and Fulei Nie
DOI: 10.2174/1573406415666191002152441

Prediction and Analysis of Hub Genes in Renal Cell Carcinoma based on CFS Gene Selection Method Combined with Adaboost Algorithm

Volume: 16   Issue: 5
Pp: 654-663
Yina Wang, Benrong Zheng, Manbin Xu, Shaoping Cai, Jeong Younseo, Chi Zhang* and Boxiong Jiang*
DOI: 10.2174/1573406415666191004100744

Recent Advancement in Predicting Subcellular Localization of Mycobacterial Protein with Machine Learning Methods

Volume: 16   Issue: 5
Pp: 605-619
Shi-Hao Li, Zheng-Xing Guan, Dan Zhang, Zi-Mei Zhang, Jian Huang, Wuritu Yang* and Hao Lin*
DOI: 10.2174/1573406415666191004101913

The Assessment of Interleukin-18 on the Risk of Coronary Heart Disease

Volume: 16   Issue: 5
Pp: 626-634
Weiju Sun, Ying Han, Shuo Yang, He Zhuang, Jingwen Zhang, Liang Cheng* and Lu Fu*
DOI: 10.2174/1573406415666191004115128

Application of Machine Learning Methods in Predicting Nuclear Receptors and their Families

Volume: 16   Issue: 5
Pp: 594-604
Zi-Mei Zhang, Zheng-Xing Guan, Fang Wang, Dan Zhang and Hui Ding*
DOI: 10.2174/1573406415666191004125551

Computational Analysis and Synthesis of Syringic Acid Derivatives as Xanthine Oxidase Inhibitors

Volume: 16   Issue: 5
Pp: 643-653
Neelam Malik, Anurag Khatkar* and Priyanka Dhiman
DOI: 10.2174/1573406415666191004134346

Integrative Analysis of Whole-genome Expression Profiling and Regulatory Network Identifies Novel Biomarkers for Insulin Resistance in Leptin Receptor-deficient Mice

Volume: 16   Issue: 5
Pp: 635-642
Yuchi Zhang, Xinyu Wu, Cong Zhao, Kai Li, Yi Zheng, Jing Zhao and Pengling Ge*
DOI: 10.2174/1573406415666191004135450

Dairy Safety Prediction Based on Machine Learning Combined with Chemicals

Volume: 16   Issue: 5
Pp: 664-676
Jiahui Chen, Guangya Zhou, Jiayang Xie, Minjia Wang, Yanting Ding, Shuxian Chen, Sijing Xia, Xiaojun Deng*, Qin Chen* and Bing Niu*
DOI: 10.2174/1573406415666191004142810

Preliminary Anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas

Volume: 16   Issue: 5
Pp: 677-688
Sandra Piras, Paola Corona, Roberta Ibba, Federico Riu, Gabriele Murineddu, Giuseppina Sanna, Silvia Madeddu, Ilenia Delogu, Roberta Loddo* and Antonio Carta*
DOI: 10.2174/1573406416666191226142744

Computational Analysis in Medicinal Chemistry. The Case of Pharmacogenomics and Pharmacoproteomics promotion: free to download

Volume: 16   Issue: 5
Pp: 593-593
Hao Lin
DOI: 10.2174/157340641605200608102355

Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In Vitro and In Silico Study

Volume: 16   Issue: 4
Pp: 575-591
Muniza Shaikh, Salman Siddiqui, Humaira Zafar, Uzma Naqeeb, Fakiha Subzwari, Rehan Imad, Khalid M. Khan and Muhammad I. Choudhary*
DOI: 10.2174/1573406415666190212105718

Novel Coupled Molecules from Active Structural Motifs of Synthetic and Natural Origin as Immunosuppressants

Volume: 16   Issue: 4
Pp: 544-554
Richa Minhas, Gulshan Bansal and Yogita Bansal*
DOI: 10.2174/1573406415666190409111459

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

Volume: 16   Issue: 4
Pp: 454-486
Smita Verma , Vishnuvardh Ravichandiran, Nihar Ranjan and Swaran J.S. Flora*
DOI: 10.2174/1573406415666190416120801

Design and Biological Evaluation of Novel Imidazolyl Flavonoids as Potent and Selective Protein Tyrosine Phosphatase Inhibitors

Volume: 16   Issue: 4
Pp: 563-574
Rong Y. Han, Yu Ge, Ling Zhang* and Qing M. Wang
DOI: 10.2174/1573406415666190430125547

Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

Volume: 16   Issue: 4
Pp: 431-453
Xiao-hua Cai*, Hong-yan Zhang and Bing Xie*
DOI: 10.2174/1573406415666190507121744

New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and In Vitro Pharmacological Evaluation

Volume: 16   Issue: 4
Pp: 517-530
Elisa Magli, Beatrice Severino*, Angela Corvino, Elisa Perissutti, Francesco Frecentese, Irene Saccone, Flavia Giordano, Marián Castro, José Brea, María I. Loza, Vincenzo Santagada, Giuseppe Caliendo and Ferdinando Fiorino
DOI: 10.2174/1573406415666190613153220

Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents

Volume: 16   Issue: 4
Pp: 531-543
Shaheen Faizi*, Tahira Sarfaraz, Saima Sumbul, Almas Jabeen, Sobia A. Halim, Mohammad A. Mesaik and Zaheer Ul-Haq*
DOI: 10.2174/1573406415666190626121650

Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives

Volume: 16   Issue: 4
Pp: 487-494
Natália N. Santiago, Giulianna P. de Alcântara, Juliana S. da Costa, Samir A. Carvalho, Juliana M.C. Barbosa, Kelly Salomão, Solange L. de Castro, Henrique M.G. Pereira and Edson F. da Silva*
DOI: 10.2174/1573406415666190712115237

Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents

Volume: 16   Issue: 4
Pp: 555-562
Taiping Chen, Hongwu Jiang, Jianjun Zhou, Zicheng Li*, Wencai Huang, Youfu Luo and Yinglan Zhao
DOI: 10.2174/1573406415666190712120611

Novel Furan Coupled Quinoline Diamide Hybrid Scaffolds as Potent Antitubercular Agents: Design, Synthesis and Molecular Modelling

Volume: 16   Issue: 4
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Anantacharya Rajpurohit, Nayak D. Satyanarayan*, Lokesh Pathak, Siva Ayyanar, Chidambaram R. Rishinaradamangalam and Praveen Shoorapani
DOI: 10.2174/1573406415666190904124630

Synthesis of Silver Nanoparticles using Euphorbia wallichii Extract and Assessment of their Bio-functionalities

Volume: 16   Issue: 4
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Abdul-Rehman Phull*, Attarad Ali, Akhtar Ali, Sanaullah Abbasi, Muhammad Zia, Muhammad H. Khaskheli, Ihsan ul Haq and Mohammad A. Kamal*
DOI: 10.2174/1573406415666191111143213