Medicinal Chemistry

Editor-in-Chief

Dimitra Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy
Aristotle University of Thessaloniki
Thessaloniki
(Greece)

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

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Most Accessed Articles

Synthesis, Antimicrobial Evaluation and Docking Study of Novel 3,5-Disubstituted-2-Isoxazoline and 1,3,5-Trisubstituted-2-Pyrazoline Derivatives open access plus

Volume: 17   Issue: 5
Pp: 462-473
Ahmed H. Ismail, Ahmed M. Abdula*, Ivan H.R. Tomi, Ali H.R. Al-Daraji and Younis Baqi*
DOI: 10.2174/1573406415666191107121757

Synthesis, Molecular Docking and Biological Evaluation of Novel Flavone Derivatives as Potential Anticancer Agents Targeting Akt

Volume: 17   Issue: 2
Pp: 158-170
Heba M. Abo-Salem, Abdullah A Gibriel*, Mohamed E. El Awady and Adel H. Mandour
DOI: 10.2174/1573406416666200306115035

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy open access plus

Volume: 17   Issue: 2
Pp: 97-120
Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*
DOI: 10.2174/1573406416666191227120425

Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities

Volume: 16   Issue: 7
Pp: 881-891
Beatriz C. Marques, Mariana B. Santos, Daiane B. Anselmo, Diego A. Monteiro, Eleni Gomes, Marilia F.C. Saiki, Paula Rahal, Pedro L. Rosalen, Janaina C.O. Sardi and Luis O. Regasini*
DOI: 10.2174/1573406415666190724145158

Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study

Volume: 17   Issue: 3
Pp: 216-229
Uma Krithika, Prabhakaran Prabitha, Subhankar P. Mandal, Sivamani Yuvaraj, Durai Priya, Ashish D. Wadhwani and Bommenahally Ravanappa Prashantha Kumar*
DOI: 10.2174/1573406416666200610191002

Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

Volume: 16   Issue: 6
Pp: 774-783
Mayara S.S. do Nascimento, Vitória R.F. Câmara, Juliana S. da Costa, Juliana M.C. Barbosa, Alessandra S.M. Lins, Kelly Salomão, Solange L. de Castro, Samir A. Carvalho, Edson F. da Silva and Carlos A.M. Fraga*
DOI: 10.2174/1573406415666190627103013

In silico Study to Evaluate the Antiviral Activity of Novel Structures against 3C-like Protease of Novel Coronavirus (COVID-19) and SARS-CoV

Volume: 17   Issue: 4
Pp: 380-395
Kiran Chunduru, Runali Sankhe, Farmiza Begum, Nalini Sodum, Nitesh Kumar*, Anoop Kishore, Rekha R. Shenoy, Chamallamudi M. Rao and Kavitha Saravu
DOI: 10.2174/1573396316999200727125522

Discovery of Substituted N-(6-Chloro-3-cyano-4-phenyl-4H-chromen-2-yl)- 2-(4-chloro-phenoxy)-acetamide for Biphasic Anticancer and Anticonvulsant Activities

Volume: 17   Issue: 3
Pp: 203-215
Divya Chauhan*, Syad Riaz Hashim, Prinka Rani, Sushil Kumar, Navratan Shrimal, Divya Shastri and Vinit Raj*
DOI: 10.2174/1573406415666191206101617

The Introduction of Hydrazone, Hydrazide, or Azepane Moieties to the Triterpenoid Core Enhances an Activity Against M. tuberculosis

Volume: 17   Issue: 2
Pp: 134-145
Oxana B. Kazakova*, Natalya I. Medvedeva, Irina E. Smirnova, Tatyana V. Lopatina and Alexander V. Veselovsky
DOI: 10.2174/1573406416666200115161700

Structure-Activity Relationship Study of an Alkynylphosphonate and Vynilphosphonate Analogues of Calcitriol

Volume: 17   Issue: 3
Pp: 230-246
Silvina M. Grioli, Eliana N. Alonso, Evangelina Mascaró, Santiago A. Stabile, María J. Ferronato, Mario A. Quevedo, Gabriel Radivoy, María M. Facchinetti, Cristian A. Vitale and Alejandro C. Curino*
DOI: 10.2174/1573406416999200818145115

Structure-Based Design, Synthesis, Biological Evaluation and Molecular Docking Study of 4-Hydroxy-N'-methylenebenzohydrazide Derivatives Acting as Tyrosinase Inhibitors with Potentiate Anti-Melanogenesis Activities promotion: free to download

Volume: 16   Issue: 7
Pp: 892-902
Aida Iraji, Mahsima Khoshneviszadeh, Pegah Bakhshizadeh, Najmeh Edraki* and Mehdi Khoshneviszadeh*
DOI: 10.2174/1573406415666190724142951

Xanthone: A Promising Antimycobacterial Scaffold

Volume: 17   Issue: 4
Pp: 310-331
Tilal Elsaman, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla and Magdi Awadalla Mohamed*
DOI: 10.2174/1573406416666200619114124

Exploring the Molecular Mechanisms of 17β-HSD5-induced Carcinogenicity of Catha edulis via Molecular Modeling Approach

Volume: 17   Issue: 4
Pp: 418-428
Maria Saeed, Sajda Ashraf, Rashad Alsanosi, Hassan A. Alhazmi, Mohammed AlBratty, Asim Najmi, Asaad Khalid* and Zaheer Ul-Haq*
DOI: 10.2174/1573406416666201005142522

Novel Coumarin Containing Dithiocarbamate Derivatives as Potent α-Glucosidase Inhibitors for Management of Type 2 Diabetes

Volume: 17   Issue: 3
Pp: 264-272
Marjan Mollazadeh, Maryam Mohammadi-Khanaposhtani, Yousef Valizadeh, Afsaneh Zonouzi, Mohammad A. Faramarzi, Mitra Kiani, Mahmood Biglar, Bagher Larijani, Haleh Hamedifar , Mohammad Mahdavi * and Mir Hamed Hajimiri*
DOI: 10.2174/1573406416666200826101205

The Interaction of Schistosoma Japonicum Glutathione Transferase with Cibacron Blue 3GA and its Fragments

Volume: 17   Issue: 4
Pp: 332-343
Michalis Platis, Dimitrios Vlachakis, Ahmed I. Foudah, Magdy M. Muharram, Mohamed H. Alqarni, Anastassios C. Papageorgiou and Nikolaos E. Labrou*
DOI: 10.2174/1573406416666200403074742

Site-directed Fragnomics and MD Simulations Approaches to Identify Interleukin-2 Inhibitors

Volume: 17   Issue: 4
Pp: 407-417
Ruqaiya Khalil, Saman Usmani, Mohammad Nur-e-Alam, Sarfaraz Ahmed and Zaheer Ul-Haq*
DOI: 10.2174/1573406416999201113104501

Novel Aminopyrazole Tagged Hydrazones as Anti-Tubercular Agents: Synthesis and Molecular Docking Studies

Volume: 17   Issue: 4
Pp: 344-351
Thatavarthi Padmini, Darna Bhikshapathi, Kandagatla Suresh, Ravindra Kulkarni* and Bigala R. Kamal
DOI: 10.2174/1573406416666200514084747

Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated/ N-Tiophosphorylated Tacrine

Volume: 16   Issue: 7
Pp: 947-957
Maja Przybyłowska, Iwona Inkielewicz-Stepniak, Szymon Kowalski, Krystyna Dzierzbicka*, Sebastian Demkowicz and Mateusz Daśko
DOI: 10.2174/1573406415666190716115524