Medicinal Chemistry

Editor-in-Chief

Dimitra Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy
Aristotle University of Thessaloniki
Thessaloniki
(Greece)

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

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Volume: 7 Issue: 6, November

Analysis of the α-Glucosidase Inhibitory Activity of Chromenone Derivatives Based on their Molecular Features: A Computational Study

Volume:7   Issue: 6
Pp: 526-533
N. S. Hari Narayana Moorthy, Maria J. Ramos and Pedro A. Fernandes
DOI: 10.2174/157340611797928389
Published on: 01 March, 2012

Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors

Volume:7   Issue: 6
Pp: 534-542
Yubin Wang, Hai Qian, Jinpei Zhou, Huibin Zhang, Jianfeng Ji and Wenlong Huang
DOI: 10.2174/157340611797928271
Published on: 01 March, 2012

3D-QSAR of Novel Phosphodiesterase-4 Inhibitors by Genetic Function Approximation

Volume:7   Issue: 6
Pp: 543-552
Anand V. Raichurkar, Ujashkumar A. Shah and Vithal M. Kulkarni
DOI: 10.2174/157340611797928352
Published on: 01 March, 2012

A QSAR Study on Some Series of HIV-1 Integrase Inhibitors

Volume:7   Issue: 6
Pp: 553-560
Shikha Kaushik, Satya P. Gupta, P. K. Sharma and Zaihra Anwar
DOI: 10.2174/157340611797928361
Published on: 01 March, 2012

Syntheses of 2,3-Diarylated 2H-Benzo[e][1,2]Thiazine 1,1-Dioxides and their 3,4-Dihydro Derivatives, and Assessment of their Inhibitory Activity Against MCF-7 Breast Cancer Cells

Volume:7   Issue: 6
Pp: 561-571
Yuan-Yuan Shan, Cheng-Mei Zhang, Long-Qiang Tang, Zhao-Peng Liu, Nicole R. Bearss, Jeffrey G. Sarver, Amarjit Luniwal and Paul W. Erhardt
DOI: 10.2174/157340611797928307
Published on: 01 March, 2012

Synthesis of 2,4,6-Trichlorophenyl Hydrazones and their Inhibitory Potential Against Glycation of Protein

Volume:7   Issue: 6
Pp: 572-580
Khalid Mohammed Khan, Zarbad Shah, Viqar Uddin Ahmad, Momin Khan, Muhammad Taha, Fazal Rahim, Humera Jahan, Shahnaz Perveen and M. Iqbal Choudhary
DOI: 10.2174/157340611797928415
Published on: 01 March, 2012

Pharmacophoric Modeling and Atom-Based 3D-QSAR of Novel 1-Aryl-3-(1-acylpiperidin-4-yl) Urea as Human Soluble Epoxide Hydrolase Inhibitors (sEHIs)

Volume:7   Issue: 6
Pp: 581-592
Nirupam Das, Meenakshi Dhanawat, Akanksha Kulshrestha and Sushant K. Shrivastava
DOI: 10.2174/157340611797928479
Published on: 01 March, 2012

Synergism from Combination of Cisplatin and Multicentred Platinums Coded as DH6Cl and TH1 in the Human Ovarian Tumour Models

Volume:7   Issue: 6
Pp: 593-598
Ali Alshehri, Philip Beale, Jun Qing Yu and Fazlul Huq
DOI: 10.2174/157340611797928316
Published on: 01 March, 2012

Synthesis and Antitumoral Evaluation of 7-chloro-4-quinolinylhydrazones Derivatives

Volume:7   Issue: 6
Pp: 599-604
Raquel Carvalho Montenegro, Leticia Veras Lotufo, Manoel Odorico de Moraes, Claudia do O Pessoa, Felipe Augusto Rocha Rodrigues, Marcelle de Lima Ferreira Bispo, Laura Nogueira de Faria Cardoso, Carlos Roland Kaiser and Marcus Vinicius Nora de Souza
DOI: 10.2174/157340611797928299
Published on: 01 March, 2012

Novel 3-(2-(3-methyl-5-substituted-phenyl-4,5-dihydropyrazol-1-yl)-2-oxoethoxy)-2-substituted-phenyl-4H-chromen-4-one: Synthesis and Anticancer Activity

Volume:7   Issue: 6
Pp: 605-610
Xin-Hua Liu, Jun Li, Fan-Rong Wu, Bao-An Song, Pinaki S. Bhadury and Lei Shi
DOI: 10.2174/157340611797928442
Published on: 01 March, 2012

Synthesis and Antitubercular Activity of New L-serinyl Hydrazone Derivatives

Volume:7   Issue: 6
Pp: 611-623
Alessandra Campbell Pinheiro, Carlos Roland Kaiser, Thais Cristina Mendonca Nogueira, Samir Aquino Carvalho, Edson Ferreira da Silva, Larisse de Oliveira Feitosa, Maria das Gracas Muller de Oliveira Henriques, Andre Luis Peixoto Candea, Maria Cristina Silva Lourenco and Marcus Vinicius Nora de Souza
DOI: 10.2174/157340611797928325
Published on: 01 March, 2012

Design, Synthesis and Antitumor Activity of Novel D-Glucuronic Acid Derivatives

Volume:7   Issue: 6
Pp: 624-638
Ahmed O. H. El-Nezhawy, Frady G. Adly, Ahmed F. Eweas, Atef G. Hanna, Yehya M. El-Kholy, Shahenaz H. El-Syed and Tarek B. A. El-Naggar
DOI: 10.2174/157340611797928398
Published on: 01 March, 2012

Free Radical Scanvenging and Antioxidant Effects of Some Anthraquinone Derivatives

Volume:7   Issue: 6
Pp: 639-644
Abderrahmane Baghiani, Noureddine Charef, Meriem Djarmouni, Haythem A. Saadeh, Lekhmici Arrar and Mohammad S. Mubarak
DOI: 10.2174/157340611797928424
Published on: 01 March, 2012

In silico Designing and Screening of Lead Compounds to NS5-Methyltransferase of Dengue Viruses

Volume:7   Issue: 6
Pp: 655-662
Dakshinamurthy Sivakumar and Thirunavukkarasu Sivaraman
DOI: 10.2174/157340611797928451
Published on: 01 March, 2012

Synthesis of Novel 8-Hydroxy Quinolin Based 1,3,4-oxadiazoles and S-substituted 1,2,4-triazole Derivatives and Evaluation of their Anti-inflammatory, Analgesic, Ulcerogenic and Anti-Microbial Activities

Volume:7   Issue: 6
Pp: 663-673
Mohammad Mahboob Alam, Mohammad Shaharyar, Hinna Hamid, Syed Nazreen, Saqlain Haider and Mohammad Sarwar Alam
DOI: 10.2174/157340611797928334
Published on: 01 March, 2012

Antibacterial Activity of Thyme and Lavender Essential Oils

Volume:7   Issue: 6
Pp: 674-689
Monika Sienkiewicz, Monika Lysakowska, Julita Ciecwierz, Pawel Denys and Edward Kowalczyk
DOI: 10.2174/157340611797928488
Published on: 01 March, 2012

Antimicrobial Activity and SAR Study of Some Novel Thiosemicarbazide Derivatives Bearing Piperidine Moiety

Volume:7   Issue: 6
Pp: 690-696
Agata Siwek and Joanna Stefanska
DOI: 10.2174/157340611797928406
Published on: 01 March, 2012

Synthesis, Structure and Antibacterial Evaluation of Some N-substituted 3-amino-5-hydroxy-4-phenyl-1H-pyrazole-1-carboxamides

Volume:7   Issue: 6
Pp: 697-703
Monika Pitucha, Urszula Kosikowska, Liliana Urszula and Anna Malm
DOI: 10.2174/157340611797928433
Published on: 01 March, 2012

Synthesis and in vitro Leishmanicidal Activity of Disulfide Derivatives

Volume:7   Issue: 6
Pp: 704-710
Khalid Mohammed Khan, Muhammad Taha, Farzana Naz, Momin Khan, Fazal Rahim, Samreen, Shahnaz Perveen and M. Iqbal Choudhary
DOI: 10.2174/157340611797928460
Published on: 01 March, 2012

Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic βCells

Volume:7   Issue: 6
Pp: 711-717
Lucia Rackova, Ahmet Cumaoglu, E. Umit Bagrιacιk, Milan Stefek, Pierre Maechler and Cimen Karasu
DOI: 10.2174/157340611797928370
Published on: 01 March, 2012

Cloning, Expression and Characterization of Mouse (Mus musculus) Nicotinamide 5-Mononucleotide Adenylyltransferase-2

Volume:7   Issue: 6
Pp: 718-726
David W. Raches, Suhong Xiao, Praveen Kusumanchi, Joel Yalowitz, Paresh Sanghani, Eric C. Long, Asok C. Antony and Hiremagalur N. Jayaram
DOI: 10.2174/157340611797928262
Published on: 01 March, 2012

Synthesis and Evaluation of Biological Activities of a Series of (6-substitutedbenzothiazol-2-yl)acrylamides

Volume:7   Issue: 6
Pp: 727-731
Nguyen-Hai Nam, Phan Thi Phuong Dung, Doan Thanh Hieu, Le Hoang, Tran Thi Hien, Tran The Cuong and Phan Dinh Chau
DOI: 10.2174/157340611797928280
Published on: 01 March, 2012