Medicinal Chemistry

Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
(Greece)

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

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Volume:14   Issue: 4
Pp: 321-321
Wolf-Rainer Abraham
DOI: 10.2174/157340641404180514151754



The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells

Volume:14   Issue: 4
Pp: 322-332
Ketan C. Ruparelia*, Keti Zeka, Taeeba Ijaz, Dyan N. Ankrett, Nicola E. Wilsher, Paul C. Butler, Hoon L. Tan, Sabahat Lodhi, Avninder S. Bhambra, Gerard A. Potter, Randolph R.J. Arroo and Kenneth J.M. Beresford
DOI: 10.2174/1573406414666180112120134




Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity

Volume:14   Issue: 4
Pp: 333-343
Maya Z. Gibson, Minh A. Nguyen and Sarah K. Zingales*
DOI: 10.2174/1573406413666171020121244




Synthesis, Cytotoxicity Evaluation, Molecular Docking and Utility of Novel Chalcones as Precursors for Heterocycles Incorporating Pyrazole Moiety

Volume:14   Issue: 4
Pp: 344-355
Sobhi M. Gomha*, Magda A. Abdallah, Ikhlass M. Abbas and Mariam S.H. Kazem
DOI: 10.2174/1573406413666171020114105




Synthesis of New Isoxazole-, Pyridazine-, Pyrimidopyrazines and Their Anti-Inflammatory and Analgesic Activity

Volume:14   Issue: 4
Pp: 356-371
Ameen A. Abu-Hashem* and Mohamed El-Shazly
DOI: 10.2174/1573406414666180112110947




Synthesis and in vitro Antioxidant Activity Study of Some Novel Substituted Piperazinyl Flavone Compounds

Volume:14   Issue: 4
Pp: 372-386
Elmas Sari, Pawel Berczynski, Aleksandra Kladna, Irena Kruk, Oya Bozdag Dundar, Monika Szymanska and Hassan Y. Aboul-Enein*
DOI: 10.2174/1573406414666171204105000




A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs

Volume:14   Issue: 4
Pp: 387-393
Maria Arkel, Patrizia Garbati, Annalisa Salis, Gianluca Damonte, Nara Liessi, Enrico Adriano, Umberto Benatti, Maurizio Balestrino and Enrico Millo*
DOI: 10.2174/1573406413666171120164702




Activity of Rifabutin and Hemi-synthetic Derivatives Against Mycobacterium abscessus

Volume:14   Issue: 4
Pp: 394-399
Ivy B. Ramis*, Ricardo Figueiredo, Daniela F. Ramos, Priscila C.B. Halicki, Andrea von Groll, Miguel Viveiros, Maria do Ceu Costa and Pedro E.A. da Silva
DOI: 10.2174/1573406414666171204102633




Efficient One-Pot Access to Trisubstituted 2-Benzazepin-3-ones as Constrained Pseudopeptide Analogues and Privileged Scaffolds

Volume:14   Issue: 4
Pp: 400-408
Olivier Van der Poorten, Mouhamad Jida*, Dirk Tourwe and Steven Ballet*
DOI: 10.2174/1573406413666171002122233




Design, Synthesis, Evaluation and Computational Studies of Nipecotic Acid-Acetonaphthone Hybrids as Potential Antiepileptic Agents

Volume:14   Issue: 4
Pp: 409-426
Ankit Seth, Piyoosh A. Sharma, Avanish Tripathi, Priyanka K. Choubey, Pavan Srivastava, Prabhash N. Tripathi and Sushant K. Shrivastava*
DOI: 10.2174/1573406414666180116104225