Medicinal Chemistry

Editor-in-Chief

Dimitra Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy
Aristotle University of Thessaloniki
Thessaloniki
(Greece)

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

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Volume: 12 Issue: 4, June 2016

Molecular Modeling, de novo Design and Synthesis of a Novel, Extracellular Binding Fibroblast Growth Factor Receptor 2 Inhibitor Alofanib (RPT835)

Volume:12   Issue: 4
Pp: 303-317
Ilya Tsimafeyeu, Frits Daeyaert, Jean-Baptiste Joos, Koen V. Aken, John Ludes-Meyers, Mikhail Byakhov and Sergei Tjulandin
DOI: 10.2174/1573406412666160106154726
Published on: 06 January, 2016

Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator

Volume:12   Issue: 4
Pp: 318-327
Kunio Yui, George Imataka and Yohei Kawasaki
DOI: 10.2174/1573406412666160107113725
Published on: 06 January, 2016

Discovery and Optimization of 1-(4-chloro-3-(trifluoromethyl)- phenyl)-3-(2-(amino)pyridin-3-yl)ureas as Novel KDR Kinase Inhibitors

Volume:12   Issue: 4
Pp: 328-337
Yu Jiao, Fei Huang, Pengfei Xu, Yanmin Zhang, Shangyan Yang, Danfeng Zhang, Tao Lu and Weifang Tang
DOI: 10.2174/1573406412666151215105149
Published on: 14 December, 2015

Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors

Volume:12   Issue: 4
Pp: 338-346
Yan Xia, Qiong Duan, Bao-Hua Zhao, Dong-Feng Li and Rui-Bin Hou
DOI: 10.2174/1573406412666151109113007
Published on: 08 November, 2015

Identification of New Inhibitors for Human SIRT1: An in-silico Approach

Volume:12   Issue: 4
Pp: 347-361
Balasundaram Padmanabhan, Manjula Ramu, Shruti Mathur, Sruthi Unni and Saravanamuthu Thiyagarajan
DOI: 10.2174/1573406412666160107111612
Published on: 06 January, 2016

Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase

Volume:12   Issue: 4
Pp: 362-370
Kamil Musilek, Jan Hambalek, Ondrej Holas, Vlastimil Dohnal and Kamil Kuca
DOI: 10.2174/1573406411666151002125640
Published on: 02 October, 2015

Pharmacophore and QSAR Modeling of Neuronal Nitric Oxide Synthase Ligands and Subsequent Validation and In Silico Search for New Scaffolds

Volume:12   Issue: 4
Pp: 371-393
Ghadeer Suaifan, Mayadah Shehadeh, Hebah Al-Ijel, Khuloud T. Al-Jamal and Mutasem Taha
DOI: 10.2174/1573406411666151002130609
Published on: 02 October, 2015

Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-diaryl-5-(4-pyridinyl)-1,2,4-oxadiazole

Volume:12   Issue: 4
Pp: 394-401
Bita Zareian, Sajad Ghadbeighi, Amirali Amirhamzeh, Seyed N. Ostad, Abbas Shafiee and Mohsen Amini
DOI: 10.2174/1573406412666151112125149
Published on: 12 November, 2015