Letters in Organic Chemistry

5-Methoxy-1-methyl-2-{[4-(2-hydroxyphenyl)piperazin-1-yl]methyl}-1Hindole (KAD22) with Antioxidant Activity

Volume: 18   Issue:
Pp: 1-1
Agnieszka A. Kaczor*, Karolina Wojtunik-Kulesza, Tomasz M. Wróbel, Dariusz Matosiuk and Monika Pitucha
DOI: 10.2174/1570178618666210119121438

An Efficient One Pot, Multicomponent Synthesis of 1, 3-Thiazolidin-4-Ones Using L-Proline as Catalyst in Water

Volume: 18   Issue:
Pp: 1-1
Yatin U. Gadkari , Rajesh D. Shanbhag and Vikas N. Telvekar*
DOI: 10.2174/1570178618666210119121734

Studies towards the Synthesis of the Pyrido[1,2-a]azepine Alkaloids

Volume: 18   Issue:
Pp: 1-1
DauXuan Duc*
DOI: 10.2174/1570178618666210120110111

Synthesis, Characterization, and Antimicrobial Evaluation of New Furan2-Carboxamide Derivatives

Volume: 18   Issue:
Pp: 1-1
Kamal Sweidan*, Gada Idrees, Luay Abu-Qatouseh, Muhammad Nawaz Tahir, Monther Khanfar, Rajendra Joshi, Eyad Mallah and Mohammsad S. Mubarak
DOI: 10.2174/1570178618666210125161436

Miscellaneous Passerini Reaction for α-Acyloxy Carboxamide: Synthesis and Process Optimization Study

Volume: 18   Issue:
Pp: 1-1
Amita J. Jivani, Khushal M. Kapadiya* and Ranjan C. Khunt
DOI: 10.2174/1570178618666210125161922

Visible Light Mediated, Catalyst Free, One-Pot Convenient Synthesis of Dihydropyridines

Volume: 18   Issue:
Pp: 1-1
Jia-Qi Di, Meng-Nan Chen, Ai-Dong Zhao* and Zhan-Hui Zhang*
DOI: 10.2174/1570178618666210125162342

Cu-Catalyzed Cascade Reaction of Isoxazoles with Diaryliodonium Salts for the Synthesis of Acridines

Volume: 17   Issue: 12
Pp: 944-950
Shangrong Zhu, Xuechen Lu, Qiuneng Xu, Jian Li* and Shenghu Yan*
DOI: 10.2174/1570178617666200225125427

Synthesis, Antiproliferative Activity and Molecular Docking of New Thiazole/Benzothiazole Fused Pyranopyrimidine Derivatives

Volume: 17   Issue: 12
Pp: 951-958
Pallava Nagaraju , Pedavenkatagari Narayana Reddy*, Pannala Padmaja* and Vinod G. Ugale
DOI: 10.2174/1570178617666200319114611

Enzyme-assisted Cyclization of Chalcones to Flavanones

Volume: 17   Issue: 12
Pp: 926-931
Mariana Macías Alonso*, Carlos José Boluda , Gabriela Díaz Barajas, Nallely Caldera Sánchez, Iván Córdova-Guerrero and Joaquín González Marrero*
DOI: 10.2174/1570178617666200319115406

Novel 1,2,3-Triazole-functionalized pyrido[3',2':4,5]furo[3,2-d]pyrimidin- 4(3H)-one Derivatives: Synthesis, Anticancer Activity, CoMFA and CoMSIA Studies

Volume: 17   Issue: 12
Pp: 969-978
Balakishan Vadla and Sailu Betala*
DOI: 10.2174/1570178617666200319124017

Design, Synthesis, Anticancer Activity and Molecular Docking Studies of 2,5-Disubstituted-1,3,4-Oxadiazoles Containing Benzimidazole Moiety

Volume: 17   Issue: 12
Pp: 959-968
Ramamurthy Katikireddy, Ramu Kakkerla *, M.P.S. Murali Krishna, Gandamalla Durgaiah and Y.N. Reddy
DOI: 10.2174/2212797613666200320102503

Synthesis and Theoretical Study of a Series of 3,5-disubstitutes Pyrazoles

Volume: 17   Issue: 12
Pp: 932-938
Karine Braga Enes, Ana Clara Alves Branco, Maria Eduarda Toledo Lima, Marcella Fernandes Mano Mateus, Luciana Guimaráes, Clebio Soares Nascimento and Mara Rubia Costa Couri*
DOI: 10.2174/1570178617666200409095632

Isolation and Identification of a Potent PTP1B Inhibitor, Ursolic Acid, from Carolina Jasmine (Gelsemium sempervirens (L.) J.St.-Hil.)

Volume: 17   Issue: 12
Pp: 939-943
Toshiro Noshita *, Yusuke Kakizoe, Satoshi Tanabe, Hidekazu Ouchi and Akihiro Tai
DOI: 10.2174/1570178617666200409101248

Recent Development in the Chemistry of Bicyclic 6+5 Systems, Part II: Chemistry of Triazolopyrimidine Derivatives

Volume: 17   Issue: 12
Pp: 897-925
Moustafa A. Gouda*, Ameen Ali Abu-Hashem*, Hoda Abdel Raouf Hussein and Ahmed S. Aly
DOI: 10.2174/1570178617666200417121205

Acknowledgements to Reviewers promotion: free to download

Volume: 17   Issue: 12
Pp: 979-984

DOI: 10.2174/157017861712201208091717

One-pot Pseudo-Domino Three-Component Knoevenagel Condensation Reaction in Water Enabled by Micellar Catalyst: Mechanism and Reactivity

Volume: 17   Issue: 11
Pp: 823-831
Dini Ahanthem, Devi Prasan Ojha, Francis A.S. Chipem and Warjeet S. Laitonjam*
DOI: 10.2174/1570178616666190701102542

Squaramide-Catalyzed Enantioselective Michael Addition of Pyrazol-3- ones to ortho-Quinone Methides

Volume: 17   Issue: 11
Pp: 837-844
Laura Carceller-Ferrer, Gonzalo Blay*, José R. Pedro* and Carlos Vila
DOI: 10.2174/1876402911666190806105543

Synthesis of Highly Functionalized Quinazoline-2,4(1H,3H)-diones from Isocyanides, Aniline and Isocyanate via Cu-Catalyzed Intermolecular C-H Activation Reactions

Volume: 17   Issue: 11
Pp: 832-836
Manijeh Nematpour, Hossein Fasihi Dastjerdi, Mehdi Jahani and Sayyed Abbas Tabatabai*
DOI: 10.2174/1570178616666190905142545

4-Anilidopiperidine Derivatives for in vivo Imaging of μ-Opioid Receptors

Volume: 17   Issue: 11
Pp: 845-856
János Marton*, Attila Sipos, Sándor Berényi, Brita Glaenzel and Gjermund Henriksen*
DOI: 10.2174/1570178616666190905144136

Chiral Mn(III) Salen Complex Immobilized on CuFe2O4@SiO2-NH2 NPs: A Cheap and Efficient Catalyst for N-arylation of Aryl Halides and Phenylboronic Acid Under Mild Conditions

Volume: 17   Issue: 11
Pp: 857-863
Mohammad Ali Nasseri *, Seyyedeh Ameneh Alavi, Milad Kazemnejadi and Ali Allahresani
DOI: 10.2174/1570178616666190919110639

An Effective Assembling of Novel Derivatives Containing Both Benzo[d]thiazole and Benzo[d]oxazole Rings

Volume: 17   Issue: 11
Pp: 815-822
Nguyen Thi Ngoc Mai, Duong Quoc Hoan*, Vu Thi Anh Tuyet, Tran Thi Thu Trang, Duong Khanh Linh and Trinh Thi Huan
DOI: 10.2174/1570178617666200207104912

Improvements in the Acylation of 3-Methylindole Using Amberlyst-15

Volume: 17   Issue: 11
Pp: 890-896
Darío A. Vargas, Leticia J. Méndez and Alicia S. Cánepa*
DOI: 10.2174/1570178617666200207110109

2,5-Dihydroxyterephthalic Acid Accelerated Cu(NO₃)₂.3H₂O-Catalyzed Homocoupling Reaction of Arylboronic Acids

Volume: 17   Issue: 11
Pp: 877-883
Fengtian Wu, Chenlong Nan, Jianwei Xie and Mingyang Ma*
DOI: 10.2174/1570178617666200210110041

Computational Study on the Kinetics and Mechanisms of Unimolecular Reactions of (Z)-(Z)-N-(λ5-phosphanylidene) Formohydrazonic Formic Anhydride: Intramolecular aza-Wittig Reaction in Competition with Mumm Rearrangement

Volume: 17   Issue: 11
Pp: 884-889
Somayeh Mirdoraghi, Hamed Douroudgari, Farideh Piri and Morteza Vahedpour*
DOI: 10.2174/1570178617666200224103813

Design, Synthesis and Anticancer Evaluation of Acetamides Comprising 1,2,3-triazole, 1,3,4-thiadiazole and Isothiazolo[4,3-b]pyridine Rings

Volume: 17   Issue: 11
Pp: 864-871
Shaik Shahinshavali, Nuthalapati Poojith, Venkat Rao Guttikonda, Reddymasu Sreenivasulu and Mandava Venkata Basaveswara Rao*
DOI: 10.2174/1570178617666200225102939

Exploring the Neighbouring Group Participatory Mechanism in Glycosylation Reaction

Volume: 17   Issue: 11
Pp: 872-876
Kamlesh Sharma*
DOI: 10.2174/1570178617666200225104704

Synthesis of New C2-Symmetric Chiral Benzimidazole Derivatives Having Norbornene/Dibenzobarrelene Skeletons

Volume: 17   Issue: 10
Pp: 801-805
İrfan Çapan and Süleyman Servi*
DOI: 10.2174/1570178616666190731105327

The Study on Chlorination by Sulfuryl Chloride of Benzene/Pyridine Carboxamides and Carbonitriles

Volume: 17   Issue: 10
Pp: 788-794
Weiqing Yang, Yongjing Cao, Hongrui Cheng, Qingrong Sun and Menglin Ma*
DOI: 10.2174/1570178617666191203101254

A Computational Study of the Conformational Behavior of 2,5-Dimethyl- 1,4-dithiane-2,5-diol and Analogous S and Se: DFT and NBO Study

Volume: 17   Issue: 10
Pp: 749-759
Elmira Danaie, Shiva Masoudi* and Nasrin Masnabadi
DOI: 10.2174/1570178617666200129144750

Synthesis of (E)-1,2-Bis[4-[di(1H-pyrrol-2-yl)methyl]phenyl]ethene as a New Bis(dipyrromethane) Building Block

Volume: 17   Issue: 10
Pp: 795-800
Faride Ranjbari, Salar Hemmati* and Mohammad Reza Rashidi
DOI: 10.2174/1570178617666200207102604

In-Situ Synthesis of Active Pharmaceutical Ingredients Which Content Pyrazole Skeleton

Volume: 17   Issue: 10
Pp: 743-748
Sultan Pathan, Anil Repale and Girdhar Pal *
DOI: 10.2174/1570178617666200207110526

Synthesis of 5-amino-1-aryl-3-methyl-1H-pyrazole-4-carbonitriles, Antifungal Activity and In Silico Analysis

Volume: 17   Issue: 10
Pp: 779-787
Luciana Terra, Daiane de Jesus Viegas, Alice Maria Rolim Bernardino, Jéssica Venância Faria, Percilene Fazolin Vegi, Rômulo Gabriel De Miranda de Paula Pinto, Maurício Silva dos Santos, Helena Carla Castro and Paula Alvarez Abreu*
DOI: 10.2174/1570178617666200210105246

Computational Study on the Mechanism of Cycloaddition Reactions of Bissulfonyl-1,3-butadiene with Some Alkenes

Volume: 17   Issue: 10
Pp: 735-742
Sepideh Masoumifar, Mina Haghdadi* and Hassan Ghasemnejad Bosra
DOI: 10.2174/1570178617666200210112307

Preparation and Characterization of Soybean Oil-based Flame Retardant Rigid Polyurethane Foams Containing Phosphaphenanthrene Groups

Volume: 17   Issue: 10
Pp: 760-771
Qirui Gong, Niangui Wang*, Kaibo Zhang, Shizhao Huang and Yuhan Wang
DOI: 10.2174/1570178617666200224104336

Arylhydrazono/Aryldiazenyl Pyrazoles: Green One-Pot Solvent-Free Synthesis and Anticancer Evaluation

Volume: 17   Issue: 10
Pp: 772-778
Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Yahya I. Asiri, Jaber Abdullah Alshehri, Yahia N. Mabkhot, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Mater H. Mahnashi and Mohd. Zaheen Hassan*
DOI: 10.2174/1570178617666200320104923

Efficient Synthesis of 2-[(3,4-Dichlorophenyl)methyl]-1H-benzimidazole Derivatives, and their α-Glucosidase Inhibitory and Antioxidant Activities

Volume: 17   Issue: 10
Pp: 806-814
Emre Menteşe, Fatih Yılmaz* and Nimet Baltaş
DOI: 10.2174/1570178617666200330130024

PEG1000 as a Low Melting and Ecofriendly Solvent for Air Oxidative and Catalyst Free 2,4-Disubstitute Quinazoline Synthesis

Volume: 17   Issue: 9
Pp: 709-716
Ebrahim Saeedian Moghadam, Shahrzad Ghafary and Mohsen Amini*
DOI: 10.2174/1570178616666190417122005

Asymmetric Reactions in Water Catalyzed by L-Proline Tethered on Thermoresponsive Ionic Copolymers open access plus

Volume: 17   Issue: 9
Pp: 717-725
Noriyuki Suzuki*, Daisuke Mizuno, Armando M. Guidote, Shun Koyama, Yoshiro Masuyama and Masahiro Rikukawa
DOI: 10.2174/1570178616666190819141307

Cytotoxic Prenyl and Geranyl Coumarins from the Stem Bark of Casimiroa edulis

Volume: 17   Issue: 9
Pp: 680-687
Khun Nay Win Tun, Nanik Siti Aminah*, Alfinda Novi Kristanti, Rico Ramadhan and Yoshiaki Takaya
DOI: 10.2174/1570178616666191019121437

A Novel Copper-Catalyzed Synthesis of N-Monosubstituted 2-Alkynimidamides from 1-Alkynes and Trichloroacetamidines

Volume: 17   Issue: 9
Pp: 704-708
Hossein Fasihi Dastjerdi, Manijeh Nematpour, Elham Rezaee, Mehdi Jahani and Sayyed Abbas Tabatabai*
DOI: 10.2174/1570178616666191023142821

MoO₃ Nanoparticles as an Efficient Catalyst for the Synthesis of Pyrazoles in Aqueous-alcoholic Medium at Room Temperature

Volume: 17   Issue: 9
Pp: 694-703
Sonatai Patil*, Ananda Mane and Savita Dhongade-Desai
DOI: 10.2174/1570178617666191127103433

Thiazolidine-2, 4-Diones as Non-Hepatotoxic Tri-action Drug Candidates: Design, Synthesis, Characterization, Biological Evaluation and Docking Studies

Volume: 17   Issue: 9
Pp: 659-679
Karuna S. Shukla, Shailendra Pandey and Pooja A. Chawla*
DOI: 10.2174/1570178617666191220142852

Synthesis, Photophysics and Theoretical Calculation of (E)-2-(benzo[d] thiazol-2-yl)-3-(3-methoxyphenyl)acrylonitrile

Volume: 17   Issue: 9
Pp: 688-693
Pei-Chieh Wu and Chih-Hsien Chen*
DOI: 10.2174/1570178617666200207103147

A Rationale for the Ortho Effect in Electrophilic Aromatic Substitutions

Volume: 17   Issue: 9
Pp: 655-658
Timothy Eckert*, Grace Harmeyer, Steven Legate and Steven Mathe
DOI: 10.2174/1570178617666200207103755

Trifunctionalized Allenes. Part IV. Cyclization Reactions of 4-Phosphorylated 5-Hydroxyhexa-2,3-dienoates

Volume: 17   Issue: 9
Pp: 726-733
Ismail E. Ismailov, Ivaylo K. Ivanov and Valerij Ch. Christov*
DOI: 10.2174/1570178617666200225104238

Active γ –Alumina -Supported Ru Nanoparticles for CO2 Hydrogenation Reaction

Volume: 17   Issue: 8
Pp: 603-612
Prashant Gautam and Vivek Srivastava*
DOI: 10.2174/1570178617666191107112429

Metal-Free Synthesis of Pyrimidinone Derivatives via Biginelli Reaction Using Aqueous NaICl2

Volume: 17   Issue: 8
Pp: 613-617
Navnath T. Hatvate, Shrikant M. Ghodse, Krishna N. Mundlod and Vikas N. Telvekar*
DOI: 10.2174/1570178617666191126095808

Application of Amine-based Ru Compounds in the Olefin Metathesis of Methyl Eugenol: A Comparison with Grubbs Catalysts

Volume: 17   Issue: 8
Pp: 596-602
Denise A. Sousa, Paulo S. Meneses, Patrik D.S. Gois, Eliada A. Silva, Valdemiro P.C. Junior, Benedito S. Lima-Neto and José L. Silva Sá*
DOI: 10.2174/1570178617666191127102552

Synthesis of C3-Quaternary 2H-Pyrrolines by [3+2] Cycloaddition of Isocyanoacetates and 1,1-Disubstituted Alkenes

Volume: 17   Issue: 8
Pp: 586-589
Yi Cheng, Runmei Zhang, Tianhao Lu, Yong Shen, Min Wang and Chunsong Xie*
DOI: 10.2174/1570178617666191218104959

Chiral Catalysts Utilized in the Nucleophilic Addition of Dialkyl-zinc Reagents to Carbonyl Compounds

Volume: 17   Issue: 8
Pp: 571-585
Adnan Cetin*
DOI: 10.2174/1570178617666191220145038

Synthesis, Antibacterial and Antioxidant Activities of Some New Nsubstituted Azachalcone, Schiff base and Pyrazole Derivatives

Volume: 17   Issue: 8
Pp: 631-638
Nedime Çalışkan, Asu Usta*, Fatih Şaban Beriş, Nimet Baltaş and Efsun Çelik
DOI: 10.2174/1570178617666200108111211

Trihaloisocyanuric Acids: Useful Reagents for Conversion of Benzaldehydes into Benzylidene Dihalides under Appel Conditions

Volume: 17   Issue: 8
Pp: 590-595
Haryadylla da C. Sindra, Carlos Vinícius P. dos Santos and Marcio C.S. de Mattos*
DOI: 10.2174/1570178617666200121110618

Synthesis, Crystal Structure, Luminescence, and Nonlinear Optical Properties of 2-[(E)-[[4-[2-(4-Methoxyphenyl)ethynyl]phenyl] imino]methyl]-4- [(E)-phenyldiazenyl]phenol

Volume: 17   Issue: 8
Pp: 618-623
Sagar Subhash Mohite, Aditya Babasaheb Patil-Deshmukh and Sanjay Shamrao Chavan*
DOI: 10.2174/1570178617666200207104157

Synthesis of TFA-protected α-Amino Acid Chloride via a Vilsmeier Reagent for Friedel–Crafts Acylation

Volume: 17   Issue: 8
Pp: 645-653
Zetryana Puteri Tachrim, Kazuhiro Oida, Fumina Ohashi, Natsumi Kurokawa, Lei Wang, Takeyuki Suzuki and Makoto Hashimoto *
DOI: 10.2174/1570178617666200207111127

A Simple Synthesis of the Anticancer Drug Altretamine

Volume: 17   Issue: 8
Pp: 628-630
Vu Binh Duong, Pham Van Hien, Tran Thai Ngoc, Phan Dinh Chau and Tran Khac Vu*
DOI: 10.2174/1570178617666200210111041

Regioselective IED Diels-Alder Reaction of Bis-(4,6-dichloro-[1,3,5]triazin- 2-yl)-diazene with Furan and Its Molecular Mechanism

Volume: 17   Issue: 8
Pp: 639-644
Andrew Karkhut, Sviatoslav Polovkovych, Roman Lesyk* and Volodymyr Novikov
DOI: 10.2174/1570178617666200210111928

Facile One-Pot Synthesis and Crystal Structure of 2:1 Adducts of Myrcene (or Ocimene) with Benzoquinones

Volume: 17   Issue: 8
Pp: 624-627
Sujata V. Bhat*, Rohan S. Pawar and P. Rajakannu
DOI: 10.2174/1570178617666200227110001

Multi-component Preparation of Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines Using Solvent-free and HSBM Techniques

Volume: 17   Issue: 7
Pp: 512-516
Seyyed Jalal Roudbaraki, Morteza Ziyaadini and Majid Ghashang*
DOI: 10.2174/1570178616666190319155522

Efficient and Regioselective Ring-opening of Epoxides with Carboxylic Acid Catalyzed by Graphite Oxide

Volume: 17   Issue: 7
Pp: 532-538
Maryam Mirza-Aghayan*, Mahdieh Molaee Tavana, Elaheh Golam Alipour Niazi and Rabah Boukherroub
DOI: 10.2174/1570178616666190401194252

Synthesis and Characterization of GO-Chit-Ni Nanocomposite as a Recoverable Nanocatalyst for Reducing Nitroarenes in Water

Volume: 17   Issue: 7
Pp: 523-531
Mosayeb Sarvestani and Roya Azadi*
DOI: 10.2174/1570178616666190806125217

Zeolite Catalyzed Friedel-Crafts Reactions: A Review

Volume: 17   Issue: 7
Pp: 491-506
Yogeesha N. Nayak, Swarnagowri Nayak, Y.F. Nadaf, Nitinkumar S. Shetty and Santosh L. Gaonkar*
DOI: 10.2174/1570178616666190807101012

One-Pot Green Synthesis of Some Novel N-Substituted 5-Amino-1,3,4- Thiadiazole Derivatives

Volume: 17   Issue: 7
Pp: 517-522
Azizollah Habibi *, Sahar Khosravi , Seyyed M. Shahcheragh and Mohd B. Abdul Rahman
DOI: 10.2174/1570178616666190926105533

Dual Catalytic Activity of Amberlyst-15 in the Large-scale and Sustainable Synthesis of Dioctyl Sodium Sulfosuccinate (DOSS)

Volume: 17   Issue: 7
Pp: 555-559
Mojtaba Tarin*, Seyed M.M. Moghadam, Samie Salehi and Davod S. Fateh*
DOI: 10.2174/1570178616666191009105703

Green and Efficient Synthesis of Fluorescent Bis(pyrazolyl)methanes in Choline Chloride/Urea Deep Eutectic Solvent

Volume: 17   Issue: 7
Pp: 548-554
Adeleh Moshtaghi Zonouz*, Masoumeh Beiranvand, Rahim Mohammad-Rezaei and Soheila Naderi
DOI: 10.2174/1570178617666191111121813

Synthesis, Characterization and Antimicrobial Activity Evaluation of the Polybenzimidazole Derivatives with Different Dicarboxylic Acid Moieties

Volume: 17   Issue: 7
Pp: 539-547
Bilge Eren*, Fadime Özdemir Koçak and Gülcan Erdoğan
DOI: 10.2174/1570178617666191114105457

An Efficient Ultrasonic-Assisted Synthesis of Enol Carbamates via Oxidative Coupling of Formamides with 1,3-Dicarbonyl Compounds

Volume: 17   Issue: 7
Pp: 507-511
Jafar Akbari* and Alireza Akbari Meyestani
DOI: 10.2174/1570178617666191126095420

Synthesis, Toxicity Profile and Pharmacological Evaluation of Some New N,N-Diphenyl Amine Derivatives with Special Reference to Analgesic and Anti-inflammatory Activity

Volume: 17   Issue: 7
Pp: 560-570
Arvind Kumar* and Arun K. Mishra
DOI: 10.2174/1570178617666191220150024

Preparation, Characterization, and Application of Ru-Silica-Ionic Liquid System for CO2 Hydrogenation Reaction

Volume: 17   Issue: 6
Pp: 443-454
Prashant Gautam, Praveenkumar Ramprakash Upadhyay and Vivek Srivastava*
DOI: 10.2174/1570178616666190429150333

Facile Access to 2-Substituted Benzoxazoles Using Sawdust Supported N-Heterocyclic Carbene-Ni Complex via C-H Activation

Volume: 17   Issue: 6
Pp: 479-489
Dolly Kale, Gajanan Rashinkar, Audumbar Patil, Arjun Kumbhar and Rajashri Salunkhe*
DOI: 10.2174/1570178616666190705153927

The Difference in Sensing Properties Towards Anions between Two Pyridinium Amide-Based Receptors with a Subtle Change of H-Bond Position

Volume: 17   Issue: 6
Pp: 472-478
Wei-tao Gong*, Wei-dong Qu and Guiling Ning
DOI: 10.2174/1570180816666190801100603

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

Volume: 17   Issue: 6
Pp: 438-442
Xiaofang Ma*, Shunxi Li, Samrat Devaramani *, Guohu Zhao and Daqian Xu
DOI: 10.2174/1570178616666190926104037

Lipids and Free Fatty Acids of Red Sea Avrainvillea amadelpha, Holothuria atra, and Sarcocornia fruticosa Inhibit Marine Bacterial Biofilms

Volume: 17   Issue: 6
Pp: 466-471
Usama W. Hawas*, Fekri Shaher, Mohamed Ghandourah, Lamia T. Abou El-Kassem, Sathianeson Satheesh and Abdul Mohsin A. Al-Sofyani
DOI: 10.2174/1570178616666191004104031

Nano-SnCl4/SiO2 as a Catalyst for One-Pot Synthesis of Substituted 1H-Pyrazoles as Antifungal and Cytotoxic Agents

Volume: 17   Issue: 6
Pp: 459-465
Soghra Khabnadideh, Zeinab Faghih, Leila Zamani*, Kamiar Zomorodian, Bi Bi Fatemeh Mirjalili and Hadi Moradi
DOI: 10.2174/1570178617666191127104622

Chemical Compositions and Anti-cancer Activities of the Volatile Oils of Leaves and Rhizomes of Three Polianthes Species

Volume: 17   Issue: 6
Pp: 434-437
Pham Van Khang*, Hoang Phu Hiep, Ma Lei and Shen Sida
DOI: 10.2174/1570178617666191202165253

Alkylation of 2(3H)-Furanones: Inter- versus Intra-Molecular

Volume: 17   Issue: 6
Pp: 430-433
Sayed K. Ramadan*, Wael S.I. Abou-Elmagd and Ahmed I. Hashem
DOI: 10.2174/1570178617666191203102528

Anti-inflammatory Constituents from Eurycoma longifolia Roots

Volume: 17   Issue: 6
Pp: 455-458
Nguyen Minh Chau, Ha Manh Tuan, Tran Manh Hung, Nguyen Tien Dat* and Nguyen Hai Dang
DOI: 10.2174/1570178617666191218104241

Recent Advancements in Biological Activities of Oxadiazole and their Derivatives: A Review

Volume: 17   Issue: 6
Pp: 409-429
Arun Kumar Mishra*, Arvind Kumar and Jagdish K. Sahu
DOI: 10.2174/1570178617666191220115426

Design, Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Bearing Isoxazole-Pyrazole Derivatives

Volume: 17   Issue: 5
Pp: 352-359
Bhukya Ravinaik , Dittakavi Ramachandran * and Mandava Venkata Basaveswara Rao
DOI: 10.2174/1570178616666190725090906

A New Oleanane Triterpenoid from the Roots of Callerya speciosa

Volume: 17   Issue: 5
Pp: 388-392
Dao Duc Thien, Nguyen Thanh Tam*, Nguyen Thi Hoang Anh, Dong Thi Kim Cuc, Nguyen Thi Thanh Mai, Tran Duc Quan, Nguyen Hoang Sa and Trinh Thi Thuy
DOI: 10.2174/1570178616666190806124038

Chiral Thiazolidine based Organocatalysts: Synthesis and Application in Asymmetric Aldol Reactions

Volume: 17   Issue: 5
Pp: 372-380
Ana Rita G. Félix, Pedro R.D. Simões, Francisco J.P.M. Sousa, M. Elisa Silva Serra and Dina Murtinho*
DOI: 10.2174/2210681209666190807155816

Fast and Efficient One-Pot Three-Component Synthesis of Some 1,2,3,4- Tetrahydro-6-methyl-N-phenyl-5-pyrimidinecarboxamide Derivatives via Biginelli Condensation Reaction

Volume: 17   Issue: 5
Pp: 366-371
Şirin Gülten*, Ufuk Gezer and Elmas Aksanli Gündoğan
DOI: 10.2174/1570178616666190819142221

Efficient Synthesis of Novel Quinolinone Derivatives via Catalyst-free Multicomponent Reaction

Volume: 17   Issue: 5
Pp: 403-407
Rui Du, Liangliang Han, Zhongqiang Zhou* and Victor Borovkov*
DOI: 10.2174/1570178616666190828092728

A Mini-review of the Tropical Plant Cratoxylum fomosum ssp. pruniflorum: Phytochemical and Pharmacological Aspects

Volume: 17   Issue: 5
Pp: 327-339
Ninh The Son*
DOI: 10.2174/1570178616666190902111630

Preparation and Application of CuO@RHA/MCM-41 Nanocomposite for the Synthesis of Fused pyrano[4,3-b]chromenones

Volume: 17   Issue: 5
Pp: 360-365
Mohammad Nikpassand*, Leila Zare Fekri and Afshin Pourahmad
DOI: 10.2174/1570178616666190905145308

Design, Synthesis and Biological Evaluation of 3-(3,4,5-Trimethoxyphenyl)- 5-(2-(5-arylbenzo[b]thiophen-3-yl)oxazol-5-yl)isoxazole Derivatives as Anticancer Agents

Volume: 17   Issue: 5
Pp: 345-351
Syndla Premalatha, G. Rambabu, Islavathu Hatti and Dittakavi Ramachandran*
DOI: 10.2174/1570178616666191004105445

Cyclization Effect on pKa of the Side Chain of Aspartic Acid in Dipeptides: A DFT Study

Volume: 17   Issue: 5
Pp: 381-387
Mohsen Sargolzaei* and Majid Namayandeh Jorabchi
DOI: 10.2174/1570178616666191019124709

Two Novel π -Conjugated Fluorophores for Dye-Doped LC On-Off Photoluminescence Switching

Volume: 17   Issue: 5
Pp: 340-344
Rosita Diana, Barbara Panunzi* and Ugo Caruso*
DOI: 10.2174/1570178616666191104094527

Synthesis of a New Dioxaspiro[bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]deca- 1(10),8-dien-4-one Derivative Using Some Chemical Strategies

Volume: 17   Issue: 5
Pp: 393-402
Figueroa-Valverde Lauro*, Rosas-Nexticapa Marcela, Lopez-Ramos Maria, Diaz Cedillo Francisco, Mateu-Armand Virginia, Garcimarero-Espino E. Alejandra, Borges-Ballote Yaritza and Ortiz-Ake Yazmin
DOI: 10.2174/1570178617666191116123359

Influence of Carbohydrate Residues on Antibacterial Activity of Vancomycin

Volume: 17   Issue: 4
Pp: 287-293
Justyna Samaszko-Fiertek*, Monika Szulc, Barbara Dmochowska, Maciej Jaśkiewicz, Wojciech Kamysz, Rafał Ślusarz and Janusz Madaj
DOI: 10.2174/1570178616666190329225748

An Efficient, Potassium Carbonate-Catalysed, Three-Component Reaction of Aldehydes, Malononitrile and Amidines Leading to Highly Functionalized Pyrimidines in Aqueous Media

Volume: 17   Issue: 4
Pp: 281-286
Seddigheh Mohammadi, Dadkhoda Ghazanfari and Zahed Karimi-Jaberi*
DOI: 10.2174/1570178616666190401190207

A Combined Topological ELF, NCI and QTAIM Study of Mechanism and Hydrogen Bond Controlling the Selectivity of the IMDC Reaction of Nitrone-alkene Obtained from m-allyloxybenzaldehyde

Volume: 17   Issue: 4
Pp: 260-267
Fouad Chafaa, Abdelmalek Khorief Nacereddine* and Abdelhafid Djerourou
DOI: 10.2174/1570178616666190401202143

Pd-Catalyzed Carbonylation-cyclization of N′-(2-bromophenyl)benzamidines by Chloroform as a CO Precursor for the Synthesis of Quinazolin- 4(3H)-ones

Volume: 17   Issue: 4
Pp: 303-308
Abbasian Sepideh, Kabirifard Hassan* and Mahdavi Mohammad
DOI: 10.2174/1570178616666190514085642

Gold Nanoparticle Functionalized Mesoporous Silica-Chitosan as Efficient and Recyclable Catalyst for the Green One-Pot Synthesis of 4H-pyran Derivatives in Aqueous Medium

Volume: 17   Issue: 4
Pp: 268-280
Razieh Azimi, Zahra Lasemi* and Ayemeh Bagheri Hashkavayi
DOI: 10.2174/1570178616666190618113635

Synthesis and Anti Cervical Cancer Activity of Novel 5H-Thiochromeno [4,3-d]pyrimidines

Volume: 17   Issue: 4
Pp: 294-302
Dhananjay Pandya and Yogesh Naliapara*
DOI: 10.2174/1570178616666190705152116

Diarylmethanols Synthesis by Nickel(II)-catalyzed Addition of Arylboronic Acids to Aryl Aldehydes

Volume: 17   Issue: 4
Pp: 248-253
Fusheng Bie*, Xuejing Liu , Meng Wang, Haizhu Cui, Tang Li, Jie Ma and Han Cao*
DOI: 10.2174/1570178616666190724124849

Synthesis and Molecular Docking Studies of Novel Triazole Derivatives as Antioxidant Agents

Volume: 17   Issue: 4
Pp: 309-320
Musa Özil*, Güven Tacal, Nimet Baltaş and Mustafa Emirik
DOI: 10.2174/1570178616666190828200207

Synthesis, Molecular Docking, and In Vitro Investigation of 1,1'-Diaryl- 3,3'-(p-phenylenedicarbonyl) dithioureas as Urease Inhibitors

Volume: 17   Issue: 4
Pp: 254-259
Hummera Rafique*, Fizza Tahira, Syeda Zar Afshan, Muhammad Naseem, Naghmana Kausar, Aamer Saeed and Muhammad Sharif
DOI: 10.2174/1570178616666191004111058

Envirocat EPZ-10: An Efficient Catalyst for the Synthesis of 1,2,4- Triazolidine-3-thiones

Volume: 17   Issue: 4
Pp: 321-326
Pradeep M. Mhaldar and Dattaprasad M. Pore*
DOI: 10.2174/1570178616666191019144317

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Volume: 17   Issue: 4
Pp: 247-247
Alberto Marra
DOI: 10.2174/157017861704200218094620

Multigram-scale Synthesis of Building Block Nitro-imine Derivative by Using Classical Method and Ultrasound Irradiation and Conversion to Imino-alcohol Derivative, Using Camphor as Starting Material

Volume: 17   Issue: 3
Pp: 165-169
Emerson Teixeira da Silva, Adriele da Silva Araújo, Adriana Marques Moraes and Marcus Vinícius Nora de Souza*
DOI: 10.2174/1570178616666190123114922

New Procedure for the Highly Regioselective Aerobic Bromination of Aromatic Compounds Using Copper-based Nanocatalyst

Volume: 17   Issue: 3
Pp: 234-239
Jalal Albadi* and Mehdi Jalali
DOI: 10.2174/1570178616666190429145952

Design, Synthesis and Biological Evaluation of Novel Diaryl Pyrazole Derivatives as Anticancer Agents

Volume: 17   Issue: 3
Pp: 216-223
Jalal Nourmahammadi, Ebrahim Saeedian Moghadam, Zahra Shahsavari and Mohsen Amini*
DOI: 10.2174/1570178616666190514090158

A Facile One-pot Synthesis of Substituted Quinolines via Cascade Friedlander Reaction from Isoxazoles with Ammonium Formate-Pd/C and Ketones

Volume: 17   Issue: 3
Pp: 211-215
Da Chen, Xuan Wang, Runnan Wang, Yao Zhan, Xiaohan Peng, Tian Xia, Zhenming Zhang, Runlai Li* and Shu'an Li*
DOI: 10.2174/1570178616666190618091617

New Crown Ether-Based Ionic Liquids as a Green and Versatile Organocatalyst for Three-Component Synthesis of 1,5-Dihydropyrano[2,3- c]chromene Derivatives

Volume: 17   Issue: 3
Pp: 240-245
Iman Mohammadzadeh, Ali Asadipour, Abbas Pardakhty and Mehdi Abaszadeh*
DOI: 10.2174/1570178616666190620124947

Biological Evaluation and Molecular Docking Studies of Synthesized 5-Substituted-2-chlorophenyl-4-chloro Derivatives Bearing Pyridazinone Moiety

Volume: 17   Issue: 3
Pp: 170-183
Minaxi Saini, Dinesh Kumar Mehta* and Rina Das
DOI: 10.2174/1570178616666190705152605

Theoretical Computations on the Pyrolysis of Alkyl (dithio)acetates

Volume: 17   Issue: 3
Pp: 224-233
Xun Zhu*, Chen Jian, Xiuqin Zhou, Abdullah M. Asiri, Khalid A. Alamry, Ping Wu and Zhihao Huang
DOI: 10.2174/1570178616666190717123039

Design, Synthesis and Molluscicidal Activity of New Phosphorus Compounds Bearing Fluorine Substituted 1,2,4-Triazolo[3,2-c][1,2,4]triazine Derivatives

Volume: 17   Issue: 3
Pp: 184-190
Reda M. Abdel-Rahman , Abdulrahman S. Alharbi *, Nawaa A. Alshammari and Yousuf O. Adnan
DOI: 10.2174/1570178616666190718120953

Synthesis, Cytotoxic, Antibacterial and Free Radical Scavenging Activities of New 1,2,4-Triazole Schiff Bases

Volume: 17   Issue: 3
Pp: 191-198
Kwang-Chun Gan, Kooi-Mow Sim*, Tuck-Meng Lim and Kah-Cheng Teo
DOI: 10.2174/1570178616666190724114741

Synthesis and Evaluation of Isatin Derivatives as Antifungal Agents

Volume: 17   Issue: 3
Pp: 199-205
Monika Dawar , Divya Utreja*, Ritu Rani and Komalpreet Kaur
DOI: 10.2174/1570178616666190724120308

Phytochemical Constituents of Annona reticulata and their Cytotoxic Activity

Volume: 17   Issue: 3
Pp: 206-210
Ty Viet Pham, Thang Quoc Le , Anh Tuan Le , Hung Quoc Vo and Duc Viet Ho*
DOI: 10.2174/1570178616666190724123004

A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity

Volume: 17   Issue: 2
Pp: 96-100
Haibo Wang* and Xikui Liu
DOI: 10.2174/1570178616666190126153703

Synthesis, Characterization, and Dynamic Behavior of Well-defined Dithiomaleimide-functionalized Maltodextrins

Volume: 17   Issue: 2
Pp: 85-89
Francisco J. Hidalgo, Nathan A.P. Lorentz, TinTin B. Luu, Jonathan D. Tran, Praveen D. Wickremasinghe, Olnita Martini, Peter M. Iovine and Joan G. Schellinger*
DOI: 10.2174/1570178616666190212124838

K2CO3 Promoted Cascade Reaction for the Preparation of 1H-Imidazol-4- yl-1-amine Derivatives

Volume: 17   Issue: 2
Pp: 127-132
Wei Xu, Hao Yao, Xing Zhang, Changjiang Peng, Ling Li, Yuanyuan Zhang, Shan Qian, Lingling Yang* and Zhouyu Wang*
DOI: 10.2174/1570178616666190226144620

Conformational Mobility Study in Mono Quinone Derivative of Calix[4]arene by Low Temperature NMR Spectroscopy

Volume: 17   Issue: 2
Pp: 101-106
Elham Hassibi, Saeed Taghvaei Ganjali*, Mohamad Mahmoodi Hashemi, Reza Zadmard and Shahram Moradi Dehaghi
DOI: 10.2174/1570178616666190228130119

Convenient Synthesis of New Heterocycles Containing the Quinoxaline Ring System

Volume: 17   Issue: 2
Pp: 121-126
Hanan A. Mohamed, Mohammad Hayal Alotaibi, Benson M. Kariuki and Gamal A. El-Hiti*
DOI: 10.2174/1570178616666190311161505

Synthesis and Biological Potentials of 5-aryl-N-[4-(trifluoromethyl) phenyl]-1,3,4-oxadiazol-2-amines

Volume: 17   Issue: 2
Pp: 133-140
Mohamed Jawed Ahsan*, Mohd. Zaheen Hassan, Surender Singh Jadav, Mohammed H. Geesi, Mohammed Afroz Bakht, Yassine Riadi, Salahuddin, Md. Sayeed Akhtar, Mohammad Nasar Mallick and Md. Habban Akhter
DOI: 10.2174/1570178616666190401193928

A Facile, Efficient and Solvent-Free Titanium (IV) Ethoxide Catalysed Knoevenagel Condensation of Aldehydes and Active Methylenes

Volume: 17   Issue: 2
Pp: 107-115
Manjunatha M. Ramaiah, Nanjunda Swamy Shivananju and Priya Babu Shubha*
DOI: 10.2174/1570178616666190401194641

Synthesis and Preliminary Biological Properties Assessment of Novel 2-S-, 4-, 5-Substituted and Bicyclic Derivatives of 6-Methylpyrimidine-4-ol

Volume: 17   Issue: 2
Pp: 149-156
Aleksandr P. Yengoyan*, Zhermen A. Azaryan, Vergush A. Pivazyan, Emma A. Ghazaryan, Rafael A. Tamazyan and Armen G. Ayvazyan
DOI: 10.2174/1570178616666190411110415

An Efficient and Green Microwave-Assisted Synthesis of Quinoline Derivatives via Knoevengal Condensation

Volume: 17   Issue: 2
Pp: 157-163
Syed Tasqeeruddin*, Yahya Asiri and Jaber Abdullah Alsherhri
DOI: 10.2174/1570178616666190618153721

Design, Synthesis and Antimicrobial Study of Novel 1-(1,3-benzothiazol-2- yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-diones Through Ketene– imine Cycloaddition Reaction

Volume: 17   Issue: 2
Pp: 141-148
Divyani Gandhi, Ayushi Sethiya, Dinesh Kr. Agarwal, Prakash Prajapat and Shikha Agarwal*
DOI: 10.2174/1570178616666190705153224

Di[(R)-2-ethylhexyl] Phthalate, a Bioactive Metabolite First Isolated from Three Different Bacillus Species, and its Synthesis

Volume: 17   Issue: 2
Pp: 90-95
Miriam Castro, Jacqueline Jiménez, Aurelio Ortiz* and Estibaliz Sansinenea*
DOI: 10.2174/1570178616666190718125617

A Neuroinflammation Inhibitor, Hypoxylon xanthone A, from Soil Fungus Hypoxylon sp.

Volume: 17   Issue: 2
Pp: 116-120
Ying Xiao, Bing Xu, You Kang, Yuedi Li, Yong Cui*, Wei Liu and Zheng Xiang*
DOI: 10.2174/1570178616666191023100252

New Chalcone Derivative: Synthesis, Characterization, Computational Studies and Antioxidant Activity

Volume: 17   Issue: 1
Pp: 46-53
Reşat Ustabaş , Nevin Süleymanoğlu*, Namık Özdemir, Nuran Kahriman, Ersan Bektaş and Yasemin Ünver
DOI: 10.2174/1570178616666181130163115

Glucosides from the Fresh Flowers of Juglans regia L. and Their Biological Evaluation

Volume: 17   Issue: 1
Pp: 31-35
Haibo Wang* and Xikui Liu
DOI: 10.2174/1570178616666190226150248

Magnetic Organic-Inorganic Hybrid Nano System Anchored Platinum Nanoparticles for Carbon Sequestration Reaction

Volume: 17   Issue: 1
Pp: 73-83
Praveenkumar Ramprakash Upadhyay, Prashant Gautam and Vivek Srivastava*
DOI: 10.2174/1570178616666190228141754

Antioxidant Properties of Synthesis Nanometallic Pd-Ni@2- Mercaptoethanol as Effective Catalyst for Suzuki-Miyaura Reactions

Volume: 17   Issue: 1
Pp: 36-45
Khemais Said*, Ali Mesni and Ridha B. Salem
DOI: 10.2174/1570178616666190319160151

Ultrasonic Assisted Synthesis of 2, 3-Dihydroquinazolin-4(1H)-ones Involving Three-Component Reaction of Isatoic Anhydride, Amines and Pyrazole Carbaldehydes Catalyzed by [γ-Fe2O3@HAp-SO3H]

Volume: 17   Issue: 1
Pp: 24-30
Kiana F. Sina, Asieh Yahyazadeh*, Nosrat O. Mahmoodi, Kurosh R. Moghadam, Mohammad Nikpassand and Mahdi Rasa
DOI: 10.2174/1570178616666190401183953

Recent Development in the Chemistry of Bicyclic 6+5 Systems, Part I: Chemistry of Pyrazolo[3,4-b]pyridines

Volume: 17   Issue: 1
Pp: 2-23
Moustafa A. Gouda*, Moged A. Berghot, Ghada E.A. El Ghani and Abdel-Galil M. Khalil
DOI: 10.2174/1570178616666190411102031

A Scalable Synthesis of Biaryl Unit of the HIV Protease Inhibitor Atazanavir

Volume: 17   Issue: 1
Pp: 68-72
Chapala Vijayalakshmi, Malavattu G. Prasad, Naresh K. Katari* and Pedavenkatagari N. Reddy*
DOI: 10.2174/1570178616666190514080155

Water-Mediated Green and Efficient Synthesis of Bis(Indolyl)methanes Using Ammonium Iron(II) Sulfate

Volume: 17   Issue: 1
Pp: 61-67
Vikas D. Kadu, Dinesh N. Nadimetla, Mahesh G. Hublikar, Dattatraya G. Raut and Raghunath B. Bhosale*
DOI: 10.2174/1570178616666190522121135

Novel 1,3,4-Thiadiazole Linked Amide Derivatives of Pteridone: Synthesis and Study of Anticancer Activities

Volume: 17   Issue: 1
Pp: 54-60
Eeduri R. Devi, Reddymasu Sreenivasulu, Koya P. Rao, Ratnakaram V. Nadh and Malladi Sireesha*
DOI: 10.2174/1570178616666190528095548

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Volume: 17   Issue: 1
Pp: 1-1
Alberto Marra
DOI: 10.2174/157017861701191202092132

Chromene, Quinoline Hybrids as Potential Anti-Cancer Agents: A Novel and Distinct Approach for the Synthesis of Quinoline Derivatives

Volume: 17   Issue:
Pp: 1-8
Rizuana Sultana and Ravinder Reddy Tippanna*
DOI: 10.2174/1570178617666200122095829

Synthesis of Some New Polycyclic Heterocyclic Compounds of Anticipated Biological Activity

Volume: 17   Issue:
Pp: 1-10
Taghreed A. Alsufyani*, Hosam A. Saad and Asmaa A. A. Al-otaibi
DOI: 10.2174/1570178617666200207105344

Construction the A-B Bicyclic Ring Structure of Stemocurtisisne

Volume: 17   Issue:
Pp: 1-8
Duc Dau Xuan*
DOI: 10.2174/1570178617666200207105649

Synthesis and Characterization of Pine-cone Derived Carbon-based Solid Acid: a Green and Recoverable Catalyst for the Synthesis of Pyrano_ pyrazole, Amino-benzochromene, Amidoalkyl Naphthol and Thiazolidinedione Derivatives

Volume: 17   Issue:
Pp: 1-16
Fatemeh Ghorbani, Seied Ali Pourmousavi* and Hamzeh Kiyani
DOI: 10.2174/1570178617666200210105635

Synthesis, Design and Biological Evaluation of Antibacterial Activity of Novel Mixed Metal Complexes Derived from Benzoimidazolphenylethanamine and 6-Amino-N,N-dimethyluracil

Volume: 17   Issue:
Pp: 1-12
Fahad M. Alminderej*
DOI: 10.2174/1570178617666200210111442

40% aq. HF Catalyzed Three-Component Synthesis of Novel Indeno[1, 2-b][1,8]naphthyridin-6(11H)-one Derivatives and their Antimicrobial Activity

Volume: 17   Issue:
Pp: 1-10
Srinu Bhoomandla, Phani Raja Kanuparthy*, Rambabu Gundla and Ramana Reddy Bobbala
DOI: 10.2174/1570178617666200210112843

Syntheses and Cytotoxicity Screening of Some Novel 1,2,4-Triazine Derivatives against Liver Carcinoma Cell Lines

Volume: 17   Issue:
Pp: 1-6