Abstract
Molecular genetic mechanisms show diversity during prostate carcinogenesis due to extensive tumor heterogeneity and gene complexity. Understanding the molecular mechanisms involved in initiation and progression of prostate cancer will lead to the development of strategies for early detection, prevention and therapeutic intervention. This review focuses on inheritable and sporadic prostate cancer genes involved in proliferation, metastasis, angiogenesis, tumor suppression, apoptosis, and cellular stress responses.
Keywords: prostate cancer, genetic abnormality, tumor suppressor genes, oncogenes, inheritable genes, metastasis, apoptosis, transcription factors
Current Genomics
Title: Genetic Abnormalities in Prostate Cancer
Volume: 5 Issue: 1
Author(s): Sanjeev Shukla, Gregory T. MacLennan, Susan R. Marengo, Allen D. Seftel, Martin I. Resnick and Sanjay Gupta
Affiliation:
Keywords: prostate cancer, genetic abnormality, tumor suppressor genes, oncogenes, inheritable genes, metastasis, apoptosis, transcription factors
Abstract: Molecular genetic mechanisms show diversity during prostate carcinogenesis due to extensive tumor heterogeneity and gene complexity. Understanding the molecular mechanisms involved in initiation and progression of prostate cancer will lead to the development of strategies for early detection, prevention and therapeutic intervention. This review focuses on inheritable and sporadic prostate cancer genes involved in proliferation, metastasis, angiogenesis, tumor suppression, apoptosis, and cellular stress responses.
Export Options
About this article
Cite this article as:
Shukla Sanjeev, MacLennan T. Gregory, Marengo R. Susan, Seftel D. Allen, Resnick I. Martin and Gupta Sanjay, Genetic Abnormalities in Prostate Cancer, Current Genomics 2004; 5 (1) . https://dx.doi.org/10.2174/1389202043490014
DOI https://dx.doi.org/10.2174/1389202043490014 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
An Overview on Pyranocoumarins: Synthesis and Biological Activities
Current Organic Chemistry Targeted Delivery of Therapeutics to Urological Cancer Stem Cells
Current Pharmaceutical Design Recent Development and Future Prospects of Molecular Targeted Therapy in Prostate Cancer
Current Molecular Pharmacology The Urokinase-type Plasminogen Activator and the Generation of Inhibitors of Urokinase Activity and Signaling
Current Pharmaceutical Design Potentiation of Anti-Cancer Treatment by Modulators of Energy Metabolism
Current Pharmaceutical Biotechnology Molecular Pathways of Interferon-Stimulated Gene 15: Implications in Cancer
Current Protein & Peptide Science Virus as a Nanocarrier for Drug Delivery Redefining Medical Therapeutics - A Status Report
Combinatorial Chemistry & High Throughput Screening Actinium-225 in Targeted Alpha-Particle Therapeutic Applications
Current Radiopharmaceuticals Prophylaxis of Cancer
Current Cancer Therapy Reviews MicroRNA Therapeutics in Neurological Disease
Current Pharmaceutical Design New Pharmacological Approaches to the Cholinergic System: An Overview on Muscarinic Receptor Ligands and Cholinesterase Inhibitors
Recent Patents on CNS Drug Discovery (Discontinued) Tumor Angiogenesis: A Target for Renal Cell Carcinoma Therapy. Current Perspectives and Novel Strategies
Recent Patents on Biomarkers A Review on Fruit Juice Probiotication: Pomegranate
Current Nutrition & Food Science Role of Alterations in the Apoptotic Machinery in Sensitivity of Cancer Cells to Treatment
Current Pharmaceutical Design Third Generation Radiopharmaceuticals for Imaging and Targeted Therapy
Current Pharmaceutical Analysis The Clinical Applications of Heat Shock Protein Inhibitors in Cancer - Present and Future
Current Cancer Drug Targets Neurotoxicity by Synthetic Androgen Steroids: Oxidative Stress, Apoptosis, and Neuropathology: A Review
Current Neuropharmacology Single-Cell Sequencing for Drug Discovery and Drug Development
Current Topics in Medicinal Chemistry Targeting the SUMO E2 Conjugating Enzyme Ubc9 Interaction for Anti-Cancer Drug Design
Anti-Cancer Agents in Medicinal Chemistry Targeting MAPK Signalling: Prometheus Fire or Pandoras Box?
Current Pharmaceutical Design