Abstract
It is well documented that sensory transmission, including pain, is subject to endogenous inhibitory modulatory influences at dorsal horn of the spinal cord. Recent results, from behavioral to molecular studies, demonstrate that endogenous modulatory systems are bi-phasic, including inhibitory as well as new facilitatory systems. In this review, we propose the existence of endogenous facilitatory systems in the brain, and review evidence supporting the hypothesis. We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain.
Keywords: endogenous modulatory
Current Neurovascular Research
Title: Endogenous Facilitation: From Molecular Mechanisms to Persistent Pain
Volume: 1 Issue: 1
Author(s): Daphne A. Robinson, Amelita A. Calejesan, Feng Wei, Gerald F. Gebhart and Min Zhuo
Affiliation:
Keywords: endogenous modulatory
Abstract: It is well documented that sensory transmission, including pain, is subject to endogenous inhibitory modulatory influences at dorsal horn of the spinal cord. Recent results, from behavioral to molecular studies, demonstrate that endogenous modulatory systems are bi-phasic, including inhibitory as well as new facilitatory systems. In this review, we propose the existence of endogenous facilitatory systems in the brain, and review evidence supporting the hypothesis. We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain.
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Cite this article as:
Robinson A. Daphne, Calejesan A. Amelita, Wei Feng, Gebhart F. Gerald and Zhuo Min, Endogenous Facilitation: From Molecular Mechanisms to Persistent Pain, Current Neurovascular Research 2004; 1 (1) . https://dx.doi.org/10.2174/1567202043480189
DOI https://dx.doi.org/10.2174/1567202043480189 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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