Synthetic Molecules that Modulate Transcription and Differentiation: Hints for Future Drug Discovery

Title: Synthetic Molecules that Modulate Transcription and Differentiation: Hints for Future Drug Discovery

Volume: 7 Issue: 7

Author(s): Motonari Uesugi

Affiliation:

Keywords: small molecule modulation, chemical geentics, transcription, differentiation, adipogenesis

Abstract: Regulation of gene transcription and cell differentiation often induces drastic phenotypes in living organisms. External, precise control over these processes through small organic molecules represents a challenge in chemistry and biology. Our laboratory has been discovering small organic molecules that modulate transcription or differentiation and using them as a tool to understand biological phenomena. This personal perspective summarizes our contributions to chemical biology and chemical genetics in the fields of gene transcription and cell differentiation. Our case studies may foreshadow the promise and the challenge of future drug discovery.

Cite this article as:

Uesugi Motonari, Synthetic Molecules that Modulate Transcription and Differentiation: Hints for Future Drug Discovery, Combinatorial Chemistry & High Throughput Screening 2004; 7 (7) . https://dx.doi.org/10.2174/1386207043328373