Abstract
Purine bases and their bioisosteric analogs are widely used as building blocks in combinatorial chemistry. Recently a great number of fused pyrimidine derivatives became known as potential drug molecules against various types of proliferative diseases, caused by over-expression of protein kinases [1]. One of the most important compound
Keywords: pyrimidines, quinazolin-4-ones, formamidine-acetate, imidoyl-chlorides, purine analogs, protein kinase inhibitors, antiproliferative agents, phosphodiesterase v inhibitors
Current Medicinal Chemistry
Title: Improved, High Yield Synthesis of 3H-Quinazolin-4-ones, the Key Intermediates of Recently Developed Drugs
Volume: 11 Issue: 19
Author(s): Laszlo Orfi, Frigyes Waczek, Janos Pato, Istvan Varga, Balint Hegymegi-Barakonyi, Richard A. Houghten and Gyorgy Ker
Affiliation:
Keywords: pyrimidines, quinazolin-4-ones, formamidine-acetate, imidoyl-chlorides, purine analogs, protein kinase inhibitors, antiproliferative agents, phosphodiesterase v inhibitors
Abstract: Purine bases and their bioisosteric analogs are widely used as building blocks in combinatorial chemistry. Recently a great number of fused pyrimidine derivatives became known as potential drug molecules against various types of proliferative diseases, caused by over-expression of protein kinases [1]. One of the most important compound
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Cite this article as:
Orfi Laszlo, Waczek Frigyes, Pato Janos, Varga Istvan, Hegymegi-Barakonyi Balint, Houghten A. Richard and Ker Gyorgy, Improved, High Yield Synthesis of 3H-Quinazolin-4-ones, the Key Intermediates of Recently Developed Drugs, Current Medicinal Chemistry 2004; 11 (19) . https://dx.doi.org/10.2174/0929867043364423
DOI https://dx.doi.org/10.2174/0929867043364423 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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