Abstract
As our understanding of tumorigenesis increases, interference with the various signaling pathways of tumor cells has become an attractive approach to arresting tumor cell growth and overcoming chemoresistance. Among many intracellular signaling proteins, protein kinase C (PKC) isoenzymes have been identified as possible targets to render tumor cells more susceptible to apoptosis and growth arrest. We review the known biology of the α-isoenzyme of PKC in different cancers to provide a rational approach for developing targeted therapies using PKC modulators, including aprinocarsen, an antisense oligonucleotide (ASO) against PKC-α.
Keywords: pkc, protein kinase c, cancer, aprinocarsen, bryostatin
Current Pharmaceutical Design
Title: The Role of Protein Kinase C-alpha (PKC-α) in Cancer and its Modulation by the Novel PKC-α-Specific Inhibitor Aprinocarsen
Volume: 10 Issue: 16
Author(s): A- R. Hanauske, Karen Sundell and Michael Lahn
Affiliation:
Keywords: pkc, protein kinase c, cancer, aprinocarsen, bryostatin
Abstract: As our understanding of tumorigenesis increases, interference with the various signaling pathways of tumor cells has become an attractive approach to arresting tumor cell growth and overcoming chemoresistance. Among many intracellular signaling proteins, protein kinase C (PKC) isoenzymes have been identified as possible targets to render tumor cells more susceptible to apoptosis and growth arrest. We review the known biology of the α-isoenzyme of PKC in different cancers to provide a rational approach for developing targeted therapies using PKC modulators, including aprinocarsen, an antisense oligonucleotide (ASO) against PKC-α.
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Cite this article as:
Hanauske R. A-, Sundell Karen and Lahn Michael, The Role of Protein Kinase C-alpha (PKC-α) in Cancer and its Modulation by the Novel PKC-α-Specific Inhibitor Aprinocarsen, Current Pharmaceutical Design 2004; 10 (16) . https://dx.doi.org/10.2174/1381612043384376
DOI https://dx.doi.org/10.2174/1381612043384376 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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