Abstract
The application of combinatorial chemistry to glycobiology historically has proven challenging due to numerous synthetic hurdles. The advent of novel methodologies has enabled the production of natural as well as mimetic analogues for proof-of-concept experiments and SAR. This review highlights some of the recent synthetic advances in combinatorial carbohydrate synthesis. The application of carbohydrate libraries in glycobiology is also discussed.
Keywords: drug discovery, high-throughput assays, glycobiology, deprotection-coupling cycles, stereoselectivity, gram-negative bacteria
Combinatorial Chemistry & High Throughput Screening
Title: Combinatorial Chemistry in Glycobiology
Volume: 8 Issue: 2
Author(s): Obadiah J. Plante
Affiliation:
Keywords: drug discovery, high-throughput assays, glycobiology, deprotection-coupling cycles, stereoselectivity, gram-negative bacteria
Abstract: The application of combinatorial chemistry to glycobiology historically has proven challenging due to numerous synthetic hurdles. The advent of novel methodologies has enabled the production of natural as well as mimetic analogues for proof-of-concept experiments and SAR. This review highlights some of the recent synthetic advances in combinatorial carbohydrate synthesis. The application of carbohydrate libraries in glycobiology is also discussed.
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Cite this article as:
Plante J. Obadiah, Combinatorial Chemistry in Glycobiology, Combinatorial Chemistry & High Throughput Screening 2005; 8 (2) . https://dx.doi.org/10.2174/1386207053258523
DOI https://dx.doi.org/10.2174/1386207053258523 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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