Abstract
Basic science research on erectile physiology has been devoted to investigating the pathogenesis of erectile dysfunction (ED) and has led to the conclusion that ED is predominately a disease of vascular origin. It is well recognized that the incidence of ED dramatically increases in men who suffer from diabetes mellitus, hypercholesterolemia, and cardiovascular disease. Endothelial nitric oxide synthase (eNOS) is an important factor in cardiovascular homeostasis, angiogenesis, and erectile function. Given the impact of endothelial-derived nitric oxide (NO) in vascular biology, a great deal of research over the past decade has focused on the role of NO synthesis from the endothelium in normal erectile physiology as well as in disease states. Loss of the functional integrity of the endothelium and subsequent endothelial dysfunction plays an integral role in the occurrence of ED. Therefore, a likely target of gene therapy for the treatment of ED is eNOS. This communication reviews the role of eNOS in erectile physiology and discusses the alterations in eNOS expression in various vascular diseases of the penis. Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED.
Keywords: eNOS, nitric oxide, corpus cavernosum, gene transfer, diabetes, aging
Current Pharmaceutical Design
Title: Endothelial Nitric Oxide Synthase Gene Therapy for Erectile Dysfunction
Volume: 11 Issue: 31
Author(s): Trinity J. Bivalacqua, Biljana Musicki, Mustafa F. Usta, Hunter C. Champion, Philip J. Kadowitz, Arthur L. Burnett and Wayne J.G. Hellstrom
Affiliation:
Keywords: eNOS, nitric oxide, corpus cavernosum, gene transfer, diabetes, aging
Abstract: Basic science research on erectile physiology has been devoted to investigating the pathogenesis of erectile dysfunction (ED) and has led to the conclusion that ED is predominately a disease of vascular origin. It is well recognized that the incidence of ED dramatically increases in men who suffer from diabetes mellitus, hypercholesterolemia, and cardiovascular disease. Endothelial nitric oxide synthase (eNOS) is an important factor in cardiovascular homeostasis, angiogenesis, and erectile function. Given the impact of endothelial-derived nitric oxide (NO) in vascular biology, a great deal of research over the past decade has focused on the role of NO synthesis from the endothelium in normal erectile physiology as well as in disease states. Loss of the functional integrity of the endothelium and subsequent endothelial dysfunction plays an integral role in the occurrence of ED. Therefore, a likely target of gene therapy for the treatment of ED is eNOS. This communication reviews the role of eNOS in erectile physiology and discusses the alterations in eNOS expression in various vascular diseases of the penis. Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED.
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Cite this article as:
Bivalacqua J. Trinity, Musicki Biljana, Usta F. Mustafa, Champion C. Hunter, Kadowitz J. Philip, Burnett L. Arthur and Hellstrom J.G. Wayne, Endothelial Nitric Oxide Synthase Gene Therapy for Erectile Dysfunction, Current Pharmaceutical Design 2005; 11 (31) . https://dx.doi.org/10.2174/138161205774913345
DOI https://dx.doi.org/10.2174/138161205774913345 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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