Current Topics in Medicinal Chemistry

Evidences of G Coupled-Protein Receptor (GPCR) Signaling in the human Malaria Parasite Plasmodium falciparum for Sensing its Microenvironment and the Role of Purinergic Signaling in Malaria Parasites open Access plus

Volume: 21   Issue: 3
Pp: 171-180
Pedro H.S. Pereira, Lucas Borges-Pereira and Célia R.S. Garcia*
DOI:10.2174/1568026620666200826122716

Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review open Access plus

Volume: 21   Issue: 1
Pp: 28-47
Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*
DOI:10.2174/1568026620666200819160213

Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward open Access plus

Volume: 20   Issue: 32
Pp: 2959-2969
Danny Feijtel, Marion de Jong and Julie Nonnekens*
DOI:10.2174/1568026620666200226104652

Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening open Access plus

Volume: 20   Issue: 18
Pp: 1582-1592
Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa
DOI:10.2174/1568026620666200603122000

Telomere-related Markers for Cancer open Access plus

Volume: 20   Issue: 6
Pp: 410-432
Xiaotian Yuan*, Mingkai Dai and Dawei Xu*
DOI:10.2174/1568026620666200106145340

Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens open Access plus

Volume: 19   Issue: 28
Pp: 2567-2578
Rajeev K. Singla and Ashok K. Dubey*
DOI:10.2174/1568026619666191025154834

Insights into the Structural Aspects of the mGlu Receptor Orthosteric Binding Site open Access plus

Volume: 19   Issue: 26
Pp: 2421-2446
Junliang Hao* and Qi Chen
DOI:10.2174/1568026619666191011094935

Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication open Access plus

Volume: 19   Issue: 18
Pp: 1621-1649
Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*
DOI:10.2174/1568026619666190712204603

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders open Access plus

Volume: 19   Issue: 16
Pp: 1399-1417
Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*
DOI:10.2174/1568026619666190709092647

Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity open Access plus

Volume: 19   Issue: 11
Pp: 957-969
Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*
DOI:10.2174/1568026619666190510100313

Current Practice and New Developments in the Use of In Vivo Magnetic Resonance Spectroscopy for the Assessment of Key Metabolites Implicated in the Pathophysiology of Schizophrenia open Access plus

Volume: 18   Issue: 21
Pp: 1908-1924
Gerard E. Dwyer*, Kenneth Hugdahl, Karsten Specht and Renate Grüner
DOI:10.2174/1568026619666181130103559

Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends open Access plus

Volume: 18   Issue: 15
Pp: 1304-1323
Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*
DOI:10.2174/1568026618666181002113617

Mechanical Properties of Composite Hydrogels for Tissue Engineering open Access plus

Volume: 18   Issue: 14
Pp: 1214-1223
Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*
DOI:10.2174/1568026618666180810151539

Role of Biomacromolecules in Biomedical Engineering open Access plus

Volume: 18   Issue: 14
Pp: 1171-1187
Juan M. Ruso and Natalia Hassan*
DOI:10.2174/1568026618666180816155917

Analyzing of Molecular Networks for Human Diseases and Drug Discovery open Access plus

Volume: 18   Issue: 12
Pp: 1007-1014
Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*
DOI:10.2174/1568026618666180813143408

Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development open Access plus

Volume: 18   Issue: 11
Pp: 883-895
Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*
DOI:10.2174/1568026618666180711144323

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer open Access plus

Volume: 18   Issue: 6
Pp: 494-504
Nicholas S. Akins, Tanner C. Nielson and Hoang V. Le*
DOI:10.2174/1568026618666180523111351

Ubiquitin Proteasome System as a Potential Drug Target for Malaria open Access plus

Volume: 18   Issue: 5
Pp: 315-320
Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*
DOI:10.2174/1568026618666180427145308

Metabolomics Applications in Precision Medicine: An Oncological Perspective open Access plus

Volume: 17   Issue: 24
Pp: 2740-2751
Leonor Puchades-Carrasco and Antonio Pineda- Lucena*
DOI:10.2174/1568026617666170707120034

InsP3 Signaling in Apicomplexan Parasites open Access plus

Volume: 17   Issue: 19
Pp: 2158-2165
Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley
DOI:10.2174/1568026617666170130121042

LncRNA as a Therapeutic Target for Angiogenesis open Access plus

Volume: 17   Issue: 15
Pp: 1750-1757
Mohan M. Kumar and Ravi Goyal*
DOI:10.2174/1568026617666161116144744

Bioinformatics and Drug Discovery open Access plus

Volume: 17   Issue: 15
Pp: 1709-1726
Xuhua Xia*
DOI:10.2174/1568026617666161116143440

A Comprehensive Docking and MM/GBSA Rescoring Study of Ligand Recognition upon Binding Antithrombin open Access plus

Volume: 17   Issue: 14
Pp: 1631-1639
Xiaohua Zhang, Horacio Perez-Sanchez* and Felice C. Lightstone*
DOI:10.2174/1568026616666161117112604

Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future open Access plus

Volume: 16   Issue: 29
Pp: 3385-3403
Peng Li, Gretchen L. Snyder and Kimberly E. Vanover
DOI:10.2174/1568026616666160608084834

Copper Homeostasis for the Developmental Progression of Intraerythrocytic Malarial Parasite open Access plus

Volume: 16   Issue: 27
Pp: 3048-3057
Hiroko Asahi, Fumie Kobayashi, Shin-Ichi Inoue, Mamoru Niikura, Kenji Yagita and Mohammed Essa Marghany Tolba
DOI:10.2174/1568026616999160215151704

Telomerase as a Cancer Target. Development of New Molecules open Access plus

Volume: 16   Issue: 22
Pp: 2432-2440
D.L. Mengual Gomez, R.G. Armando, C.S. Cerrudo, P.D. Ghiringhelli and D.E. Gomez
DOI:10.2174/1568026616666160212122425

The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine open Access plus

Volume: 16   Issue: 18
Pp: 2009-2018
Michele Melchionna, Katie E. Styan and Silvia Marchesan
DOI:10.2174/1568026616999160212120302

HCN Channels Modulators: The Need for Selectivity open Access plus

Volume: 16   Issue: 16
Pp: 1764-1791
Maria Novella Romanelli, Laura Sartiani, Alessio Masi, Guido Mannaioni, Dina Manetti, Alessandro Mugelli and Elisabetta Cerbai
DOI:10.2174/1568026616999160315130832

Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking open Access plus

Volume: 16   Issue: 15
Pp: 1705-1716
Eric P. Trautman and Jason M. Crawford
DOI:10.2174/1568026616666151012111046

Biomarkers in the Management of Difficult Asthma open Access plus

Volume: 16   Issue: 14
Pp: 1561-1573
Florence Schleich, Sophie Demarche and Renaud Louis
DOI:10.2174/1568026616666151015093406

Cellular Selenoprotein mRNA Tethering via Antisense Interactions with Ebola and HIV-1 mRNAs May Impact Host Selenium Biochemistry open Access plus

Volume: 16   Issue: 13
Pp: 1530-1535
Ethan Will Taylor, Jan A. Ruzicka, Lakmini Premadasa and Lijun Zhao
DOI:10.2174/1568026615666150915121633

Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies open Access plus

Volume: 16   Issue: 9
Pp: 960-977
Concepcion Gonzalez-Bello
DOI:10.2174/1568026615666150825142527

αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology open Access plus

Volume: 16   Issue: 3
Pp: 314-329
Alberto Dal Corso, Luca Pignataro, Laura Belvisi and Cesare Gennari
DOI:10.2174/1568026615666150701114343

Telomere G-Quadruplex as a Potential Target to Accelerate Telomere Shortening by Expanding the Incomplete End-Replication of Telomere DNA open Access plus

Volume: 15   Issue: 19
Pp: 1940-1946
Zheng Tan, Jun Tang, Zhong-Yuan Kan and Yu-Hua Hao
DOI:10.2174/1568026615666150515145552

Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In Vitro open Access plus

Volume: 15   Issue: 18
Pp: 1914-1929
Angela Ivask, Tiina Titma, Meeri Visnapuu, Heiki Vija, Aleksandr Kakinen, Mariliis Sihtmae, Suman Pokhrel, Lutz Madler, Margit Heinlaan, Vambola Kisand, Ruth Shimmo and Anne Kahru
DOI:10.2174/1568026615666150506150109

Computer-Aided Drug Design of Bioactive Natural Products open Access plus

Volume: 15   Issue: 18
Pp: 1780-1800
Veda Prachayasittikul, Apilak Worachartcheewan, Watshara Shoombuatong, Napat Songtawee, Saw Simeon, Virapong Prachayasittikul and Chanin Nantasenamat
DOI:10.2174/1568026615666150506151101

Active Targeted Drug Delivery for Microbes Using Nano-Carriers open Access plus

Volume: 15   Issue: 15
Pp: 1525-1531
Yung-Sheng Lin, Ming-Yuan Lee, Chih-Hui Yang and Keng-Shiang Huang
DOI:10.2174/1568026615666150414123157

Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids open Access plus

Volume: 15   Issue: 15
Pp: 1491-1500
Chun-Ting Lee, Yen-Wei Huang, Chih-Hui Yang and Keng-Shiang Huang
DOI:10.2174/1568026615666150414120547

Computational Studies of Free Radical-Scavenging Properties of Phenolic Compounds open Access plus

Volume: 15   Issue: 2
Pp: 85-104
Petko Alov, Ivanka Tsakovska and Ilza Pajeva
DOI:10.2174/1568026615666141209143702

Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective? open Access plus

Volume: 14   Issue: 22
Pp: 2529-2541
Rossella Sgarbanti, Donatella Amatore, Ignacio Celestino, Maria Elena Marcocci, Alessandra Fraternale, Maria Rosa Ciriolo, Mauro Magnani, Raffaele Saladino, Enrico Garaci, Anna Teresa Palamara and Lucia Nencioni
DOI:10.2174/1568026614666141203125211

Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances open Access plus

Volume: 14   Issue: 16
Pp: 1923-1938
Evanthia Lionta, George Spyrou, Demetrios K. Vassilatis and Zoe Cournia
DOI:10.2174/1568026614666140929124445

Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS) open Access plus

Volume: 14   Issue: 3
Pp: 340-342
David H. Drewry, Timothy M. Willson and William J. Zuercher
DOI:10.2174/1568026613666131127160819

Open Innovation Drug Discovery (OIDD): A Potential Path to Novel Therapeutic Chemical Space open Access plus

Volume: 14   Issue: 3
Pp: 294-303
Maria Alvim-Gaston, Timothy Grese, Abdelaziz Mahoui, Alan D. Palkowitz, Marta Pineiro-Nunez and Ian Watson
DOI:10.2174/1568026613666131127125858

Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry open Access plus

Volume: 14   Issue: 2
Pp: 274-289
Sonny Larsson and Nina Ronsted
DOI:10.2174/1568026613666131216110417

A Brief Overview of Antimicrobial Peptides Containing Unnatural Amino Acids and Ligand-Based Approaches for Peptide Ligands open Access plus

Volume: 13   Issue: 24
Pp: 3205-3224
Jayendra B. Bhonsle, Tiffany Clark, Libero Bartolotti and Rickey P. Hicks
DOI:10.2174/15680266113136660226

Native Brazilian Plants Against Nosocomial Infections: A Critical Review on their Potential and the Antimicrobial Methodology open Access plus

Volume: 13   Issue: 24
Pp: 3040-3078
Paulo Roberto H. Moreno, Fabiana da Costa-Issa, Agnieszka K. Rajca-Ferreira, Marcos A. A. Pereira and Telma M. Kaneko
DOI:10.2174/15680266113136660219

From Polypharmacology to Target Specificity: The Case of PARP Inhibitors open Access plus

Volume: 13   Issue: 23
Pp: 2939-2954
Paride Liscio, Emidio Camaioni, Andrea Carotti, Roberto Pellicciari and Antonio Macchiarulo
DOI:10.2174/15680266113136660209

NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects open Access plus

Volume: 13   Issue: 23
Pp: 2907-2917
Christian Dölle, Renate Hvidsten Skoge, Magali R. VanLinden and Mathias Ziegler
DOI:10.2174/15680266113136660206

Recent Advances in the Synthesis of New Antimycobacterial Agents Based on the 1H-1,2,3-Triazoles open Access plus

Volume: 13   Issue: 22
Pp: 2850-2865
Daniel Tadeu G. Gonzaga, David R. da Rocha, Fernando de C. da Silva and Vitor F. Ferreira
DOI:10.2174/15680266113136660202

An Update on the Chemistry and Medicinal Chemistry of Novel Antimycobacterial Compounds open Access plus

Volume: 13   Issue: 22
Pp: 2808-2849
Frederico Silva Castelo Branco, Angelo C. Pinto and Núbia Boechat
DOI:10.2174/15680266113136660201

Synthesis and Biological Evaluation of Potent Antifungal Agents open Access plus

Volume: 13   Issue: 21
Pp: 2684-2733
Athina Geronikaki, Maria Fesatidou, Victor Kartsev and Fliur Macaev
DOI:10.2174/15680266113136660195

A Review on Antifungal Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds open Access plus

Volume: 13   Issue: 21
Pp: 2648-2659
Maria Jose Alves, Isabel C.F.R. Ferreira*, Joana Dias, Vania Teixeira, Anabela Martins and Manuela Pintado*
DOI:10.2174/15680266113136660191

Mucosal Vaccines: Where Do We Stand? open Access plus

Volume: 13   Issue: 20
Pp: 2609-2628
Jean-Pierre Kraehenbuhl and Marian R. Neutra
DOI:10.2174/15680266113136660186

Vaccine Adjuvants: Key Tools for Innovative Vaccine Design open Access plus

Volume: 13   Issue: 20
Pp: 2562-2580
Peggy Riese, Kai Schulze, Thomas Ebensen, Blair Prochnow and Carlos A. Guzmán
DOI:10.2174/15680266113136660183

Challenges and Opportunities for Cancer Vaccines in the Current NSCLC Clinical Scenario open Access plus

Volume: 13   Issue: 20
Pp: 2551-2561
Pedro C. Rodriguez and Belinda Sanchez
DOI:10.2174/15680266113136660182

Therapy in Prion Diseases open Access plus

Volume: 13   Issue: 19
Pp: 2465-2476
Gianluigi Forloni, Vladimiro Artuso, Ignazio Roiter, Michela Morbin and Fabrizio Tagliavini
DOI:10.2174/15680266113136660173

Prion Chemical Biology: On the Road to Therapeutics? open Access plus

Volume: 13   Issue: 19
Pp: 2441-2464
Beining Chen, Mark Thompson, Jennifer Louth and Kai Guo
DOI:10.2174/15680266113136660172

Drug Repurposing: Translational Pharmacology, Chemistry, Computers and the Clinic open Access plus

Volume: 13   Issue: 18
Pp: 2328-2336
Naiem T. Issa, Stephen W. Byers and Sivanesan Dakshanamurthy
DOI:10.2174/15680266113136660163

Overview on Theoretical Studies Discriminating the Two-Oxidant Versus Two-State-Reactivity Models for Substrate Monoxygenation by Cytochrome P450 Enzymes open Access plus

Volume: 13   Issue: 18
Pp: 2218-2232
Sam P. de Visser, Cristina S. Porro, Matthew G. Quesne, Mala A. Sainna and Andrew W. Munro
DOI:10.2174/15680266113136660155

Mitochondria: A Promising Target for Anticancer Alkaloids open Access plus

Volume: 13   Issue: 17
Pp: 2171-2183
Félix A. Urra, Miguel Cordova-Delgado, Hernan Pessoa-Mahana, Oney Ramírez-Rodríguez, Boris Weiss-Lopez, Jorge Ferreira and Ramiro Araya-Maturana
DOI:10.2174/15680266113139990150

Alkaloid-Metal Based Anticancer Agents open Access plus

Volume: 13   Issue: 17
Pp: 2104-2115
Zhen-Feng Chen, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang
DOI:10.2174/15680266113139990146

Retrospection on Polymorphism and Cocrystallization of Anti-Retrovirals open Access plus

Volume: 13   Issue: 16
Pp: 1933-1962
Renu Chadha, Madhu Bala, Dimpy Rani and Poonam Arora
DOI:10.2174/15680266113139990129

Targeting Host Store-Operated Ca²⁺ Release to Attenuate Viral Infections open Access plus

Volume: 13   Issue: 16
Pp: 1916-1932
Kevin B. Clark and E. M. Eisenstein
DOI:10.2174/15680266113139990128

Emerging Targets in Neurodegeneration: New Opportunities for Alzheimer's Disease Treatment? open Access plus

Volume: 13   Issue: 15
Pp: 1879-1904
Angela Rampa, Silvia Gobbi, Federica Belluti and Alessandra Bisi
DOI:10.2174/15680266113139990143

The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics open Access plus

Volume: 13   Issue: 15
Pp: 1745-1770
M. Carmo Carreiras, Eduarda Mendes, M. Jesus Perry, Ana Paula Francisco and J. Marco-Contelles
DOI:10.2174/15680266113139990135

Simultaneous Modeling of Antimycobacterial Activities and ADMET Profiles: A Chemoinformatic Approach to Medicinal Chemistry open Access plus

Volume: 13   Issue: 14
Pp: 1656-1665
Alejandro Speck-Planche and M. N.D.S. Cordeiro
DOI:10.2174/15680266113139990116

Recent Advances in Predicting Protein Classification and Their Applications to Drug Development open Access plus

Volume: 13   Issue: 14
Pp: 1622-1635
Xuan Xiao, Wei-Zhong Lin and Kuo-Chen Chou
DOI:10.2174/15680266113139990113

The Emerging Role of microRNA in Stroke open Access plus

Volume: 13   Issue: 13
Pp: 1573-1588
Georgios Koutsis, Gerasimos Siasos and Konstantinos Spengos
DOI:10.2174/15680266113139990106

Insights in microRNAs Biology open Access plus

Volume: 13   Issue: 13
Pp: 1493-1502
Antonios N. Gargalionis and Efthimia K. Basdra
DOI:10.2174/15680266113139990098

Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets open Access plus

Volume: 13   Issue: 12
Pp: 1441-1453
Brianne S. Raccor and Rudiger Kaspera
DOI:10.2174/1568026611313120006

CYP17A1: A Biochemistry, Chemistry, and Clinical Review open Access plus

Volume: 13   Issue: 12
Pp: 1364-1384
David Porubek
DOI:10.2174/1568026611313120002

Pharmacophore Modeling for ADME open Access plus

Volume: 13   Issue: 11
Pp: 1327-1342
Osman F. Guner and J. Phillip Bowen
DOI:10.2174/15680266113139990037

Permeability Diagnosis Model in Drug Discovery: A Diagnostic Tool to Identify the Most Influencing Properties for Gastrointestinal Permeability open Access plus

Volume: 13   Issue: 11
Pp: 1308-1316
Jianling Wang and Suzanne Skolnik
DOI:10.2174/15680266113139990035

Metallo-β-Lactamases: Structural Features, Antibiotic Recognition, Inhibition, and Inhibitor Design open Access plus

Volume: 13   Issue: 10
Pp: 1242-1253
Jing-Fang Wang and Kuo-Chen Chou
DOI:10.2174/15680266113139990011

Open Source Software and Web Services for Designing Therapeutic Molecules open Access plus

Volume: 13   Issue: 10
Pp: 1172-1191
Deepak Singla, Sandeep Kumar Dhanda, Jagat Singh Chauhan, Anshu Bhardwaj, Samir K. Brahmachari, Open Source Drug Discovery Consortium and Gajendra P.S. Raghava
DOI:10.2174/1568026611313100005

Protein Interface Pharmacophore Mapping Tools for Small Molecule Protein: Protein Interaction Inhibitor Discovery open Access plus

Volume: 13   Issue: 9
Pp: 989-1001
Arnout Voet, Eleanor F. Banwell, Kamlesh K. Sahu, Jonathan G. Heddle and Kam Y. J. Zhang
DOI:10.2174/1568026611313090003

A Novel Integrated Framework and Improved Methodology of Computer-Aided Drug Design open Access plus

Volume: 13   Issue: 9
Pp: 965-988
Calvin Yu-Chian Chen
DOI:10.2174/1568026611313090002

Fluorine-18 Radiolabeled Heterocycles as PET Tracers for Imaging β - Amyloid Plaques in Alzheimer’s Disease open Access plus

Volume: 13   Issue: 8
Pp: 909-919
Fanxing Zeng and Mark M. Goodman
DOI:10.2174/1568026611313080004

Fluorine-18 Labeled Amino Acids for Oncologic Imaging with Positron Emission Tomography open Access plus

Volume: 13   Issue: 8
Pp: 871-891
Chaofeng Huang and Jonathan McConathy
DOI:10.2174/1568026611313080002

Medicinal Chemistry Design Principles for Liver Targeting Through OATP Transporters open Access plus

Volume: 13   Issue: 7
Pp: 857-866
Meihua Tu, Alan M. Mathiowetz, Jeffrey A. Pfefferkorn, Kimberly O. Cameron, Robert L. Dow, John Litchfield, Li Di, Bo Feng and Spiros Liras
DOI:10.2174/1568026611313070008

Intestinal Targeting of Drugs: Rational Design Approaches and Challenges open Access plus

Volume: 13   Issue: 7
Pp: 776-802
Kevin J. Filipski, Manthena V. Varma, Ayman F. El-Kattan, Catherine M. Ambler, Roger B. Ruggeri, Theunis C. Goosen and Kimberly O. Cameron
DOI:10.2174/1568026611313070002

Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis open Access plus

Volume: 13   Issue: 6
Pp: 760-773
Jose A. Gomez-Puerta and Attila Mocsai
DOI:10.2174/15680266113139990094

The Genetic Architecture of Rheumatoid Arthritis: From Susceptibility to Clinical Subphenotype Associations open Access plus

Volume: 13   Issue: 6
Pp: 720-731
Antonio Julia and Sara Marsal
DOI:10.2174/1568026611313060005

Rheumatoid Arthritis: A Clinical Overview of New Diagnostic and Treatment Approaches open Access plus

Volume: 13   Issue: 6
Pp: 698-704
Raimon Sanmarti, Virginia Ruiz-Esquide and Maria Victoria Hernandez
DOI:10.2174/15680266113139990092

From Protein-Protein Interactions to Rational Drug Design: Are Computational Methods Up to the Challenge? open Access plus

Volume: 13   Issue: 5
Pp: 602-618
Edgar D. Coelho, Joel P. Arrais and Jose Luis Oliveira
DOI:10.2174/1568026611313050005

The Impact of Computer Science in Molecular Medicine: Enabling High- Throughput Research open Access plus

Volume: 13   Issue: 5
Pp: 526-575
Diana de la Iglesia, Miguel Garcia-Remesal, Guillermo de la Calle, Casimir Kulikowski, Ferran Sanz and Victor Maojo
DOI:10.2174/1568026611313050002

Chemistry and Theranostic Applications of Radiolabeled Nanoparticles for Cardiovascular, Oncological, and Pulmonary Research open Access plus

Volume: 13   Issue: 4
Pp: 470-478
Yunjun Guo, Tolulope Aweda, Kvar C.L. Black and Yongjian Liu
DOI:10.2174/1568026611313040007

Gd-based Macromolecules and Nanoparticles as Magnetic Resonance Contrast Agents for Molecular Imaging open Access plus

Volume: 13   Issue: 4
Pp: 411-421
Ching-Hui Huang and Andrew Tsourkas
DOI:10.2174/1568026611313040002

Endogenous Modulators of TRP Channels open Access plus

Volume: 13   Issue: 3
Pp: 398-407
Enza Palazzo, Francesco Rossi, Vito de Novellis and Sabatino Maione
DOI:10.2174/1568026611313030014

Oncogenic and Anti-Oncogenic Effects of Transient Receptor Potential Channels open Access plus

Volume: 13   Issue: 3
Pp: 344-366
Sonia Liberati, Maria Beatrice Morelli, Massimo Nabissi, Matteo Santoni and Giorgio Santoni
DOI:10.2174/1568026611313030011

MicroRNAs and the Heart: Small Things Do Matter open Access plus

Volume: 13   Issue: 2
Pp: 216-230
Nikolaos Papoutsidakis, Spyridon Deftereos, Andreas Kaoukis, Georgios Bouras, Georgios Giannopoulos, Andreas Theodorakis, Christos Angelidis, Georgios Hatzis and Christodoulos Stefanadis
DOI:10.2174/1568026611313020009

Myeloperoxidase: Expressing Inflammation and Oxidative Stress in Cardiovascular Disease open Access plus

Volume: 13   Issue: 2
Pp: 115-138
Nikolaos Anatoliotakis, Spyridon Deftereos, Georgios Bouras, Georgios Giannopoulos, Dimitrios Tsounis, Christos Angelidis, Andreas Kaoukis and Christodoulos Stefanadis
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