Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 9 Issue: 15, November

Editorial [Hot topic: Inhibition and Function of Heat Shock Proteins 70 and 90 (Guest Editor: Brian S. J. Blagg)]

Volume:9   Issue: 15
Pp: 1335-1336
Brian S. J. Blagg
DOI: 10.2174/156802609789895746
Published on: 01 March, 2012

Pharmacological Targeting of the Hsp70 Chaperone

Volume:9   Issue: 15
Pp: 1337-1351
Srikanth Patury, Yoshinari Miyata and Jason E. Gestwicki
DOI: 10.2174/156802609789895674
Published on: 01 March, 2012

Strategies for Stalling Malignancy: Targeting Cancers Addiction to Hsp90

Volume:9   Issue: 15
Pp: 1352-1368
Chrisostomos Prodromou
DOI: 10.2174/156802609789895656
Published on: 01 March, 2012

Structural and Computational Biology of the Molecular Chaperone Hsp90: From Understanding Molecular Mechanisms to Computer-Based Inhibitor Design

Volume:9   Issue: 15
Pp: 1369-1385
Gennady M. Verkhivker, Anshuman Dixit, Giulia Morra and Giorgio Colombo
DOI: 10.2174/156802609789895700
Published on: 01 March, 2012

Ansamycin Inhibitors of Hsp90: Natures Prototype for Anti-Chaperone Therapy

Volume:9   Issue: 15
Pp: 1386-1418
James R. Porter, Jie Ge, John Lee, Emmanuel Normant and Kip West
DOI: 10.2174/156802609789895719
Published on: 01 March, 2012

Hsp90 Inhibition with Resorcylic Acid Lactones (RALs)

Volume:9   Issue: 15
Pp: 1419-1435
Nicolas Winssinger, Jean-Gonzague Fontaine and Sofia Barluenga
DOI: 10.2174/156802609789895665
Published on: 01 March, 2012

Purine-Scaffold Hsp90 Inhibitors

Volume:9   Issue: 15
Pp: 1436-1446
Tony Taldone and Gabriela Chiosis
DOI: 10.2174/156802609789895737
Published on: 01 March, 2012

Alternate Strategies of Hsp90 Modulation for the Treatment of Cancer and Other Diseases

Volume:9   Issue: 15
Pp: 1447-1461
Gary E. L. Brandt and Brian S. J. Blagg
DOI: 10.2174/156802609789895683
Published on: 01 March, 2012

Assays for Identification of Hsp90 Inhibitors and Biochemical Methods for Discriminating their Mechanism of Action

Volume:9   Issue: 15
Pp: 1462-1478
Robert L. Matts and Jacob R. Manjarrez
DOI: 10.2174/156802609789895692
Published on: 01 March, 2012

Update on Hsp90 Inhibitors in Clinical Trial

Volume:9   Issue: 15
Pp: 1479-1492
Y. S. Kim, S. V. Alarcon, S. Lee, M.-J. Lee, G. Giaccone, L. Neckers and J. B. Trepel
DOI: 10.2174/156802609789895728
Published on: 01 March, 2012