Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 8 Issue: 13, September

Editorial [Hot topic: Medicinal Chemistry Strategies to Minimize hERG Channel Effects 23 May (Guest Editor:Mark T. Bilodeau)]

Volume:8   Issue: 13
Pp: 1101-1101
Mark T. Bilodeau
DOI: 10.2174/156802608785700025
Published on: 01 March, 2012

The hERG Channel and Risk of Drug-Acquired Cardiac Arrhythmia: An Overview

Volume:8   Issue: 13
Pp: 1102-1112
Armando A. Lagrutta, Elena S. Trepakova and Joseph J. Salata
DOI: 10.2174/156802608785700016
Published on: 01 March, 2012

Ligand Structural Aspects of hERG Channel Blockade

Volume:8   Issue: 13
Pp: 1113-1127
Alex M. Aronov
DOI: 10.2174/156802608785700061
Published on: 01 March, 2012

The Impact of IKr Blockade on Medicinal Chemistry Programs

Volume:8   Issue: 13
Pp: 1128-1139
Ian M. Bell and Mark T. Bilodeau
DOI: 10.2174/156802608785700034
Published on: 01 March, 2012

Overcoming hERG Affinity in the Discovery of Maraviroc; A CCR5 Antagonist for the Treatment of HIV

Volume:8   Issue: 13
Pp: 1140-1151
David A. Price, Duncan Armour, Marcel de Groot, Derek Leishman, Carolyn Napier, Manos Perros, Blanda L. Stammen and Anthony Wood
DOI: 10.2174/156802608785700007
Published on: 01 March, 2012

Lead Optimization of Melanin Concentrating Hormone Receptor 1 Antagonists with low hERG Channel Activity

Volume:8   Issue: 13
Pp: 1152-1157
Andrew S. Judd, Andrew J. Souers and Philip R. Kym
DOI: 10.2174/156802608785700052
Published on: 01 March, 2012

Molecule of the Month

Volume:8   Issue: 13
Pp: 1158-1158
Craig W. Lindsley
DOI: 10.2174/156802608785700043
Published on: 01 March, 2012