Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 7 Issue: 7, April

Editorial [Hot Topic: Modified Nucleic Acid Substructures in Medicinal Chemistry and Drug Development (Guest Editor: Dr. Vaijayanti A. Kumar)]

Volume:7   Issue: 7
Pp: 639-639
Vaijayanti A. Kumar
DOI: 10.2174/156802607780487731
Published on: 01 March, 2012

2-Modified Oligonucleotides for Antisense Therapeutics

Volume:7   Issue: 7
Pp: 641-649
Thazha P. Prakash and Balkrishen Bhat
DOI: 10.2174/156802607780487713
Published on: 01 March, 2012

Morpholino, siRNA, and S-DNA Compared: Impact of Structure and Mechanism of Action on Off-Target Effects and Sequence Specificity open access plus

Volume:7   Issue: 7
Pp: 651-660
James E. Summerton
DOI: 10.2174/156802607780487740
Published on: 01 March, 2012

True Antisense Oligonucleotides with Modified Nucleotides Restricted in the Nconformation

Volume:7   Issue: 7
Pp: 661-665
Makoto Koizumi
DOI: 10.2174/156802607780487768
Published on: 01 March, 2012

Nucleobase Modifications in Peptide Nucleic Acids

Volume:7   Issue: 7
Pp: 667-679
Filip Wojciechowski and Robert H. E. Hudson
DOI: 10.2174/156802607780487795
Published on: 01 March, 2012

Peptide Nucleic Acids with a Structurally Biased Backbone: Effects of Conformational Constraints and Stereochemistry

Volume:7   Issue: 7
Pp: 681-694
Roberto Corradini, Stefano Sforza, Tullia Tedeschi, Filbert Totsingan and Rosangela Marchelli
DOI: 10.2174/156802607780487759
Published on: 01 March, 2012

P-Chiral Oligonucleotides in Biological Recognition Processes

Volume:7   Issue: 7
Pp: 695-713
Piotr Guga
DOI: 10.2174/156802607780487786
Published on: 01 March, 2012

Structure-Editing of Nucleic Acids for Selective Targeting of RNA

Volume:7   Issue: 7
Pp: 715-726
Vaijayanti A. Kumar and K. N. Ganesh
DOI: 10.2174/156802607780487722
Published on: 01 March, 2012

Chemical Modifications to Improve the Cellular Uptake of Oligonucleotides

Volume:7   Issue: 7
Pp: 727-737
Francoise Debart, Said Abes, Gaelle Deglane, Hong M. Moulton, Philippe Clair, Michael J. Gait, Jean-Jacques Vasseur and Bernard Lebleu
DOI: 10.2174/156802607780487704
Published on: 01 March, 2012

Molecule of the Month

Volume:7   Issue: 7
Pp: 739-739
Craig W. Lindsley
DOI: 10.2174/156802607780487777
Published on: 01 March, 2012