Current Topics in Medicinal Chemistry

Editor-in-Chief

Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)

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Volume: 7 Issue: 14, July

Editorial [Hot Topic: Targeting Protein Kinases in Drug Discovery and Medicinal Chemistry (Guest Editor: Jeffrey Jie-Lou Liao)]

Volume:7   Issue: 14
Pp: 1331-1331
Liao Jie-Lou Jeffrey
DOI: 10.2174/156802607781696828
Published on: 01 March, 2012

Molecular Targeting of Protein Kinases to Optimize Selectivity and Resistance Profiles of Kinase Inhibitors

Volume:7   Issue: 14
Pp: 1332-1335
Liao Jie-Lou Jeffrey
DOI: 10.2174/156802607781696800
Published on: 01 March, 2012

The Role of Halogen Bonding in Inhibitor Recognition and Binding by Protein Kinases

Volume:7   Issue: 14
Pp: 1336-1348
Voth Regier Andrea and Ho Shing P.
DOI: 10.2174/156802607781696846
Published on: 01 March, 2012

Recent Progress in the Development of ATP-Competitive and Allosteric Akt Kinase Inhibitors

Volume:7   Issue: 14
Pp: 1349-1363
Lindsley W. Craig, Barnett F. Stanley, Yaroschak Melissa, Bilodeau T. Mark and Layton E. Mark
DOI: 10.2174/156802607781696864
Published on: 01 March, 2012

Recent Advances of MEK Inhibitors and Their Clinical Progress

Volume:7   Issue: 14
Pp: 1364-1378
Wang John (Yuan), Wilcoxen M. Keith, Nomoto Kenichi and Wu Sara
DOI: 10.2174/156802607781696837
Published on: 01 March, 2012

Molecular Design and Clinical Development of VEGFR Kinase Inhibitors

Volume:7   Issue: 14
Pp: 1379-1393
Zhong Haizhen and Bowen Phillip J.
DOI: 10.2174/156802607781696855
Published on: 01 March, 2012

Targeting Protein Multiple Conformations: A Structure-Based Strategy for Kinase Drug Design

Volume:7   Issue: 14
Pp: 1394-1407
Liao Jie-Lou Jeffrey and Andrews C. Robert
DOI: 10.2174/156802607781696783
Published on: 01 March, 2012

A Comparison of Physicochemical Property Profiles of Marketed Oral Drugs and Orally Bioavailable Anti-Cancer Protein Kinase Inhibitors in Clinical Development

Volume:7   Issue: 14
Pp: 1408-1422
Gill L. Adrian, Verdonk Marcel, Boyle G. Robert and Taylor Richard
DOI: 10.2174/156802607781696819
Published on: 01 March, 2012

Molecule of the Month

Volume:7   Issue: 14
Pp: 1423-1423
Shotwell Brad J.
DOI: 10.2174/156802607781696792
Published on: 01 March, 2012