Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Editorial [Hot Topic: Novel Cancer Therapeutic Targets (Guest Editor: George Hartman)] promotion: free to download

Volume:5   Issue: 2
Pp: 107-107
George D. Hartman
DOI: 10.2174/1568026053507679

The Akt/PKB Family of Protein Kinases: A Review of Small Molecule Inhibitors and Progress Towards Target Validation

Volume:5   Issue: 2
Pp: 109-125
Stanley F. Barnett, Mark T. Bilodeau and Craig W. Lindsley
DOI: 10.2174/1568026053507714

Mitotic Kinesins: Prospects for Antimitotic Drug Discovery

Volume:5   Issue: 2
Pp: 127-145
Gustave Bergnes, Katjusa Brejc and Lisa Belmont
DOI: 10.2174/1568026053507697

The Hedgehog Signaling Pathway as a Target for Anticancer Drug Discovery

Volume:5   Issue: 2
Pp: 147-157
Gary V. Borzillo and Blaise Lippa
DOI: 10.2174/1568026053507732

Small Molecule Inhibitors of p53/MDM2 Interaction

Volume:5   Issue: 2
Pp: 159-165
Nader Fotouhi and Bradford Graves
DOI: 10.2174/1568026053507705

Recent Advances in the Development of Selective Small Molecule Inhibitors for Cyclin-Dependent Kinases

Volume:5   Issue: 2
Pp: 167-179
Hiroshi Hirai, Nobuhiko Kawanishi and Yoshikazu Iwasawa
DOI: 10.2174/1568026053507688

Progress in the Discovery of Polo-like Kinase Inhibitors

Volume:5   Issue: 2
Pp: 181-197
Campbell McInnes, Mokdad Mezna and Peter M. Fischer
DOI: 10.2174/1568026053507660

Progress in the Development of Selective Inhibitors of Aurora Kinases

Volume:5   Issue: 2
Pp: 199-213
Andrew Mortlock, Nicholas J. Keen, Frederic H. Jung, Nicola M. Heron, Kevin M. Foote, Robert Wilkinson and Stephen Green
DOI: 10.2174/1568026053507651

Progress Towards Therapeutic Small Molecule MEK Inhibitors for Use in Cancer Therapy

Volume:5   Issue: 2
Pp: 215-229
Eli M. Wallace, Joseph P. Lyssikatos, Tammie Yeh, James D. Winkler and Kevin Koch
DOI: 10.2174/1568026053507723