Current Topics in Medicinal Chemistry

Editor-in-Chief

Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)

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Volume: 4 Issue: 14, October

Preface [Hot Topic: Perspective on VLA-4 Antagonists (Guest Editor: Jefferson W. Tilley)]

Volume:4   Issue: 14
Pp: i-i
Jefferson W. Tilley
DOI: 10.2174/1568026043387485
Published on: 01 March, 2012

The Discovery and Potential of N-Sulfonylated Dipeptide VLA-4 Antagonists

Volume:4   Issue: 14
Pp: 1461-1471
William K. Hagmann
DOI: 10.2174/1568026043387557
Published on: 01 March, 2012

The Identification and Optimization of Orally Efficacious, Small Molecule VLA-4 Antagonists

Volume:4   Issue: 14
Pp: 1473-1484
Donna M. Huryn, Andrei W. Konradi, Susan Ashwell, Stephen B. Freedman, Louis J. Lombardo, Michael A. Pleiss, Eugene D. Thorsett, Ted Yednock and Jeffrey D. Kennedy
DOI: 10.2174/1568026043387467
Published on: 01 March, 2012

Therapeutic Antagonists and the Conformational Regulation of the β2 Integrins

Volume:4   Issue: 14
Pp: 1485-1495
Motomu Shimaoka and Timothy A. Springer
DOI: 10.2174/1568026043387575
Published on: 01 March, 2012

Rational Design of Potent and Selective VLA-4 Inhibitors and their Utility in the Treatment of Asthma

Volume:4   Issue: 14
Pp: 1497-1507
Juswinder Singh, Steve Adams, Mary Beth Carter, Hernan Cuervo, Wen-Cherng Lee, Roy R. Lobb, R. Blake Pepinsky, Russell Petter and Daniel Scott
DOI: 10.2174/1568026043387520
Published on: 01 March, 2012

The Discovery of VLA-4 Antagonists

Volume:4   Issue: 14
Pp: 1509-1523
Jefferson W. Tilley, Li Chen, Achyutharao Sidduri and Nader Fotouhi
DOI: 10.2174/1568026043387502
Published on: 01 March, 2012