Current Topics in Medicinal Chemistry

Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
(USA)

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Prospects of Utilizing Computational Techniques for the Treatment of Human Diseases free to download

Volume:19   Issue: 13
Pp: 1071-1074
Anuraj Nayarisseri
DOI: 10.2174/156802661913190827102426



5-Nitro-Thiophene-Thiosemicarbazone Derivatives Present Antitumor Activity Mediated by Apoptosis and DNA Intercalation

Volume:19   Issue: 13
Pp: 1075-1091
Karla Mirella Roque Marques, Maria Rodrigues do Desterro, Sandrine Maria de Arruda, Luiz Nascimento de Araújo Neto, Maria do Carmo Alves de Lima, Sinara Mônica Vitalino de Almeida, Edjan Carlos Dantas da Silva, Thiago Mendonça de Aquino, Edeildo Ferreira da Silva-Júnior, João Xavier de Araújo-Júnior, Marina de M. Silva, Maria Dayanne de A. Dantas, Josué Carinhanha C. Santos, Isis M. Figueiredo, Marc-Antoine Bazin, Pascal Marchand, Teresinha Gonçalves da Silva and Francisco Jaime Bezerra Mendonça Junior*
DOI: 10.2174/1568026619666190621120304




Identification of Essential 2D and 3D Chemical Features for Discovery of the Novel Tubulin Polymerization Inhibitors

Volume:19   Issue: 13
Pp: 1092-1120
Fateme Azimi, Jahan B. Ghasemi*, Lotfollah Saghaei, Farshid Hassanzadeh, Mohammad Mahdavi, Hojjat Sadeghi-Aliabadi, Marcus T. Scotti and Luciana Scotti*
DOI: 10.2174/1568026619666190520083655




Application of a Validated QSTR Model for Repurposing COX-2 Inhibitor Coumarin Derivatives as Potential Antitumor Agents

Volume:19   Issue: 13
Pp: 1121-1128
Gulcin Tugcu, Hande Sipahi* and Ahmet Aydin
DOI: 10.2174/1568026619666190618143552




A Computer - Aided Drug Designing for Pharmacological Inhibition of Mutant ALK for the Treatment of Non-small Cell Lung Cancer

Volume:19   Issue: 13
Pp: 1129-1144
Saphy Sharda, Ravina Khandelwal, Ritu Adhikary, Diksha Sharma, Manisha Majhi, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*
DOI: 10.2174/1568026619666190521084941




Griseofulvin Derivatives: Synthesis, Molecular Docking and Biological Evaluation

Volume:19   Issue: 13
Pp: 1145-1161
Victor Kartsev, Athina Geronikaki*, Anthi Petrou, Boris Lichitsky, Marina Kostic, Marija Smiljkovic, Marina Soković and Samvel Sirakanyan
DOI: 10.2174/1568026619666190523080136




Forging New Scaffolds from Old: Combining Scaffold Hopping and Hierarchical Virtual Screening for Identifying Novel Bcl-2 Inhibitors

Volume:19   Issue: 13
Pp: 1162-1172
Vishnupriya Kanakaveti, Sakthivel Rathinasamy, Suresh K. Rayala and Michael Gromiha*
DOI: 10.2174/1568026619666190618142432




Identification of High-affinity Small Molecules Targeting Gamma Secretase for the Treatment of Alzheimer’s Disease

Volume:19   Issue: 13
Pp: 1173-1187
Meer Asif Ali, Sugunakar Vuree, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*
DOI: 10.2174/1568026619666190617155326