Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 18 Issue: 17, July 2018

Targeting the DCN1-UBC12 Protein-Protein Interaction for Selective Modulation of Cullin Substrates

Volume:18   Issue: 17
Pp: 1423-1425
Yuan Fang, Lei Yu, Guochao Liao* and Bin Yu*
DOI: 10.2174/156802661817181107151134
Published on: 07 November, 2018

Synthesis and Biological Profiles of 1,2,3-Triazole Scaffold free to download

Volume:18   Issue: 17
Pp: 1426-1427
Fernando de Carvalho da Silva, Vitor Francisco Ferreira and Luana da Silva Magalhães Forezi
DOI: 10.2174/156802661817181107151553
Published on: 07 November, 2018

Alternative Routes to the Click Method for the Synthesis of 1,2,3-Triazoles, an Important Heterocycle in Medicinal Chemistry

Volume:18   Issue: 17
Pp: 1428-1453
Luana da S.M. Forezi, Mariana F.C. Cardoso, Daniel T.G. Gonzaga, Fernando de C. da Silva* and Vitor F. Ferreira*
DOI: 10.2174/1568026618666180821143902
Published on: 21 August, 2018

Design, Synthesis and Antileishmanial Activity of Naphthotriazolyl-4- Oxoquinolines

Volume:18   Issue: 17
Pp: 1454-1464
Vanessa G. Oliveira, Viviane dos Santos Faiões, Gabrieli B.R. Gonçalves, Miriam F.O. Lima, Fernanda C.S. Boechat, Anna C. Cunha, Valter V. de Andrade-Neto, Fernando de C. da Silva, Eduardo C. Torres-Santos* and Maria Cecília B.V. de Souza*
DOI: 10.2174/1568026618666181002110116
Published on: 01 October, 2018

A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis

Volume:18   Issue: 17
Pp: 1465-1474
Jessica R. Branco, Vanessa G. Oliveira, Amanda M. Esteves, Ingrid C. Chipoline, Miriam F.O. Lima, Fernanda C.S. Boechat, Fernando C. da Silva, Vítor F. Ferreira, Mauro Sola-Penna, Maria C.B.V. de Souza* and Patricia Zancan*
DOI: 10.2174/1568026618666180821142458
Published on: 21 August, 2018

Novel Symmetrical 1,4-Disubstituted-bis-1,2,3-Triazoles: Synthesis by Double CuAAC and Cytotoxicity Evaluation

Volume:18   Issue: 17
Pp: 1475-1482
Wallace J. Reis, Paulo O.L. Moreira, Rosemeire B. Alves, Heloísa H.M. Oliveira, Luciana M. Silva, Fernando P. Varotti and Rossimiriam P. Freitas*
DOI: 10.2174/1568026618666181022124847
Published on: 22 October, 2018

A Novel Triazole Derivative Drug Presenting In Vitro and In Vivo Anticancer Properties

Volume:18   Issue: 17
Pp: 1483-1493
Ricardo Imbroisi Filho, Daniel T.G. Gonzaga, Thainá M. Demaria, João G.B. Leandro, Dora C.S. Costa, Vitor F. Ferreira, Mauro Sola-Penna, Fernando de C. da Silva* and Patricia Zancan*
DOI: 10.2174/1568026618666180917100640
Published on: 16 September, 2018

New Efavirenz Derivatives and 1,2,3-Triazolyl-phosphonates as Inhibitors of Reverse Transcriptase of HIV-1

Volume:18   Issue: 17
Pp: 1494-1505
Carolina C.P. Costa, Nubia Boechat*, Monica M. Bastos, Fernando de C. da Silva, Andressa Marttorelli, Thiago M.L. Souza, Mayara S. Baptista, Lucas V.B. Hoelz and Ernesto R. Cafffarena
DOI: 10.2174/1568026618666181029150118
Published on: 29 October, 2018

Oxazolone–1,2,3-Triazole Hybrids: Design, Synthesis and Antimicrobial Evaluation

Volume:18   Issue: 17
Pp: 1506-1513
Kashmiri Lal*, Lokesh Kumar, Ashwani Kumar and Anil Kumar
DOI: 10.2174/1568026618666180913110456
Published on: 12 September, 2018