Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 14 Issue: 8, April 2014

Graphical Abstracts:

Volume:14   Issue: 8
Pp: i-v

DOI: 10.2174/156802661408140423171226
Published on: 23 April, 2014

Editorial (Thematic Issue: From Phytochemistry to Medicinal Chemistry: Isolation, Semisynthesis, Evaluation and Computational Studies) free to download

Volume:14   Issue: 8
Pp: 979-980
Rajeev K. Singla, G. Varadaraj Bhat and Humberto Gonzalez-Diaz
DOI: 10.2174/1568026614666140324145723
Published on: 24 March, 2014

Antitrypanosomal Activity & Docking Studies of Components of Crateva adansonii DC Leaves: Novel Multifunctional Scaffolds

Volume:14   Issue: 8
Pp: 981-990
Ngozichukwuka Peace Igoli, Carol Jean Clements, Rajeev Kumar Singla, John Ogbaji Igoli, Nzekwe Uche and Alexander Irvine Gray
DOI: 10.2174/1568026614666140324120006
Published on: 24 March, 2014

QSAR Guided Semi-synthesis and In-Vitro Validation of Anticancer Activity in Ursolic Acid Derivatives

Volume:14   Issue: 8
Pp: 1005-1013
Komal Kalani, Dharmendra K. Yadav, Aru Singh, Feroz Khan, M.M. Godbole and S.K. Srivastava
DOI: 10.2174/1568026614666140324121606
Published on: 24 March, 2014

Antitrypanosomal Activity & Docking Studies of Isolated Constituents from the Lichen Cetraria islandica: Possibly Multifunctional Scaffolds

Volume:14   Issue: 8
Pp: 1014-1021
John Ogbaji Igoli, Alexander Irvine Gray, Carol Jean Clements, Poorna Kantheti and Rajeev Kumar Singla
DOI: 10.2174/1568026614666140324122323
Published on: 24 March, 2014

Modes of Action of Arjunolic Acid and Derivatives on Trypanosoma cruzi Cells

Volume:14   Issue: 8
Pp: 1022-1032
Lourdes C. Souza-Neta, Diego Menezes, Milena S. Lima, Martins D. Cerqueira, Frederico G. Cruz, Dirceu Martins and Marcos A. Vannier-Santos
DOI: 10.2174/1568026614666140324122800
Published on: 24 March, 2014

Structure Based Design, Synthesis, and Evaluation of Potential Inhibitors of Steroid Sulfatase

Volume:14   Issue: 8
Pp: 1033-1044
E. V. Costa, E. Sousa, K. Choosang, S. Singh, J. Rocha, R .T. Lima, P. Pakkong, S. Ahmed, M.H. Vasconcelos, C.A. Montanari and M.M. Pinto
DOI: 10.2174/1568026614666140324124807
Published on: 24 March, 2014

Protective Mechanism of Lignans from Phyllanthus amarus Against Galactosamine/ Lipopolysaccharide-Induced Hepatitis: An In-Vivo and In-Silico Studies

Volume:14   Issue: 8
Pp: 1045-1055
Dnyaneshwar U. Bawankule, Priyanka Trivedi, Anirban Pal, Karuna Shanker, Manju Singh, Pooja Sharma, Feroz Khan, Anil K. Maurya, Ram K. Verma and Madan M.Gupta
DOI: 10.2174/1568026614666140324130047
Published on: 24 March, 2014

Indole Alkaloids and Semisynthetic Indole Derivatives as Multifunctional Scaffolds Aiming the Inhibition of Enzymes Related to Neurodegenerative Diseases – A Focus on Psychotria L. Genus

Volume:14   Issue: 8
Pp: 1056-1075
Luiz Carlos Klein-Junior, Carolina dos Santos Passos, Aline Pereira Moraes, Vinicius Galvao Wakui, Eduardo Luis Konrath, Alessandra Nurisso, Pierre-Alain Carrupt, Cecilia Maria Alves de Oliveira, Lucilia Kato and Amelia Teresinha Henriques
DOI: 10.2174/1568026614666140324142409
Published on: 24 March, 2014

Insights on the Isolation, Biological Activity and Synthetic Protocols of Enyne Derivatives

Volume:14   Issue: 8
Pp: 1076-1093
Mohamed El-Shazly, Balaji D. Barve, Michal Korinek, Jing-Ru Liou, Da-Wei Chuang, Yuan-Bin Cheng, Ming-Feng Hou, Jeh-Jeng Wang, Yang-Chang Wu and Fang-Rong Chang
DOI: 10.2174/1568026614666140324143523
Published on: 24 March, 2014