Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 14 Issue: 3, February 2014

Editorial (Thematic Issue: Playing Well with Others! Initiating and Sustaining Successful Collaborations between Industry, Academia and Government)

Volume:14   Issue: 3
Pp: 291-293
Craig J. Thomas and John C. McKew
DOI: 10.2174/1568026613666131127125351
Published on: 27 November, 2013

Open Innovation Drug Discovery (OIDD): A Potential Path to Novel Therapeutic Chemical Space open access plus

Volume:14   Issue: 3
Pp: 294-303
Maria Alvim-Gaston, Timothy Grese, Abdelaziz Mahoui, Alan D. Palkowitz, Marta Pineiro-Nunez and Ian Watson
DOI: 10.2174/1568026613666131127125858
Published on: 27 November, 2013

A Unique Industrial – Academic Collaboration Towards the Next Generation of Schizophrenia Therapeutics

Volume:14   Issue: 3
Pp: 304-312
Gregor J. Macdonald and Craig W. Lindsley
DOI: 10.2174/1568026613666131127154443
Published on: 27 November, 2013

Inhibiting Caspase-6 Activation and Catalytic Activity for Neurodegenerative Diseases

Volume:14   Issue: 3
Pp: 319-325
John A. Flygare and Michelle R. Arkin
DOI: 10.2174/1568026613666131126224039
Published on: 26 November, 2013

Leveraging Public Private Partnerships to Innovate under Challenging Budget Times

Volume:14   Issue: 3
Pp: 326-329
Lili M. Portilla and Mark L. Rohrbaugh
DOI: 10.2174/1568026613666131127155703
Published on: 27 November, 2013

Collaborative Development of 2-Hydroxypropyl-β-Cyclodextrin for the Treatment of Niemann-Pick Type C1 Disease

Volume:14   Issue: 3
Pp: 330-339
Elizabeth A. Ottinger, Mark L. Kao, Nuria Carrillo-Carrasco, Nicole Yanjanin, Roopa Kanakatti Shankar, Marjo Janssen, Marcus Brewster, Ilona Scott, Xin Xu, Jim Cradock, Pramod Terse, Seameen J. Dehdashti, Juan Marugan, Wei Zheng, Lili Portilla, Alan Hubbs, William J. Pavan, John Heiss, Charles H.Vite, Steven U. Walkley, Daniel S. Ory, Steven A. Silber, Forbes D. Porter, Christopher P. Austin and John C. McKew
DOI: 10.2174/1568026613666131127160118
Published on: 27 November, 2013

Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS) open access plus

Volume:14   Issue: 3
Pp: 340-342
David H. Drewry, Timothy M. Willson and William J. Zuercher
DOI: 10.2174/1568026613666131127160819
Published on: 27 November, 2013

Editorial (Thematic Issue: Genomics and Proteomics behind Drug Design)

Volume:14   Issue: 3
Pp: 343-343
Yasset Perez-Riverol and Paulo Costa Carvalho
DOI: 10.2174/1568026613666131204101110
Published on: 03 December, 2013

Characterization of Protein Complexes using Targeted Proteomics

Volume:14   Issue: 3
Pp: 344-350
Yassel Ramos Gomez, Sebastien Gallien, Vivian Huerta, Jan van Oostrum, Bruno Domon and Luis Javier Gonzalez
DOI: 10.2174/1568026613666131204130124
Published on: 04 December, 2013

Regulation by IFN-α/IFN-γ Co-Formulation (HerberPAG®) of Genes Involved in Interferon-STAT-Pathways and Apoptosis in U87MG

Volume:14   Issue: 3
Pp: 351-358
Claudia Bello, Dania Vazquez-Blomquist, Jamilet Miranda, Yanelda Garcia, Lidia Ines Novoa, Daniel Palenzuela and Iraldo Bello
DOI: 10.2174/1568026613666131204125725
Published on: 04 December, 2013

Potential Correlation between Tumor Aggressiveness and Protein Expression Patterns of Nipple Aspirate Fluid (NAF) Revealed by Gel-Based Proteomic Analysis

Volume:14   Issue: 3
Pp: 359-368
Giselle Villa Flor Brunoro, Andre Teixeira da Silva Ferreira, Monique Ramos de Oliveira Trugilho, Tamires Sousa de Oliveira, Luis Claudio Belo Amêndola, Jonas Perales, Richard Hemmi Valente, Claudia Vitória de Moura Gallo, Dante Pagnoncelli and Ana Gisele da Costa Neves-Ferreira
DOI: 10.2174/1568026613666131204121854
Published on: 04 December, 2013

Using Mass Spectrometry-Based Peptidomics to understand the Brain and Disorders such as Parkinson’s Disease and Schizophrenia

Volume:14   Issue: 3
Pp: 369-381
Cecília Cerqueira Cafe-Mendes, Emer S. Ferro, Luiz Roberto G. Britto and Daniel Martins-de-Souza
DOI: 10.2174/1568026613666131204120747
Published on: 04 December, 2013

Proteome Analysis of Formalin-Fixed Paraffin-Embedded Tissues from a Primary Gastric Melanoma and its Meningeal Metastasis: A Case Report

Volume:14   Issue: 3
Pp: 382-387
Juliana de S. da G. Fischer, Nathalie H. S. Canedo, Katia Maria da S. Goncalves, Leila Maria Cardao Chimelli, Monique Franca, Felipe V. Leprevost, Priscila Ferreira Aquino, Paulo C. Carvalho and Maria da Gloria C. Carvalho
DOI: 10.2174/1568026613666131204114218
Published on: 03 December, 2013

A Survey of Molecular Descriptors Used in Mass Spectrometry Based Proteomics

Volume:14   Issue: 3
Pp: 388-397
Enrique Audain, Aniel Sanchez, Juan Antonio Vizcaíno and Yasset Perez-Riverol
DOI: 10.2174/1568026613666131204113537
Published on: 03 December, 2013

A Practical Guide to Sequencing Genomes and Transcriptomes

Volume:14   Issue: 3
Pp: 398-406
Alejandro Sanchez-Flores and Cei Abreu-Goodger
DOI: 10.2174/1568026613666131204142353
Published on: 03 December, 2013

Evolutionary Analysis of DNA-Protein-Coding Regions Based on a Genetic Code Cube Metric

Volume:14   Issue: 3
Pp: 407-417
Robersy Sanchez
DOI: 10.2174/1568026613666131204110022
Published on: 03 December, 2013

GARM: Genome Assembly, Reconciliation and Merging Pipeline

Volume:14   Issue: 3
Pp: 418-424
Luz Mayela Soto-Jimenez, Karel Estrada and Alejandro Sanchez-Flores
DOI: 10.2174/1568026613666131204110628
Published on: 03 December, 2013

Database Construction and Peptide Identification Strategies for Proteogenomic Studies on Sequenced Genomes

Volume:14   Issue: 3
Pp: 425-434
Celine Hernandez, Patrice Waridel and Manfredo Quadroni
DOI: 10.2174/1568026613666131204105652
Published on: 03 December, 2013

Bioinformatics Tools for the Functional Interpretation of Quantitative Proteomics Results

Volume:14   Issue: 3
Pp: 435-449
Teresa Nunez Villavicencio-Diaz, Arielis Rodriguez-Ulloa, Osmany Guirola-Cruz and Yasset Perez-Riverol
DOI: 10.2174/1568026613666131204105110
Published on: 03 December, 2013

Alterations of the Kidney Cortex Proteome in Response to Exercise Training in Normoglycemic and Hyperglycemic Conditions

Volume:14   Issue: 3
Pp: 450-461
Roger de Moraes, Richard H. Valente, Ileana R. Leon, Monique R.O. Trugilho, Antonio G. Pacheco, Antonio C.L. Nobrega, Marilia B. Gomes, Jonas Perales and Eduardo Tibirica
DOI: 10.2174/1568026613666131204115656
Published on: 03 December, 2013