Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 14 Issue: 11, June 2014

Editorial (Thematic Issue: Drug Metabolism, Toxicology Experimental Determination and Theoretical Prediction: Challenges and Perspectives from a Medicinal Chemistry Point of View) free to download

Volume:14   Issue: 11
Pp: 1323-1324
Carolina H. Andrade and Rodolpho C. Braga
DOI: 10.2174/1568026614666140506114019
Published on: 06 May, 2014

QM/MM Modelling of Drug-Metabolizing Enzymes

Volume:14   Issue: 11
Pp: 1339-1347
Richard Lonsdale and Adrian J. Mulholland
DOI: 10.2174/1568026614666140506114859
Published on: 06 May, 2014

Ritonavir Analogues as a Probe for Deciphering the Cytochrome P450 3A4 Inhibitory Mechanism

Volume:14   Issue: 11
Pp: 1348-1355
Irina F. Sevrioukova and Thomas L. Poulos
DOI: 10.2174/1568026614666140506120647
Published on: 06 May, 2014

Integrative Approaches for Predicting In Vivo Effects of Chemicals from their Structural Descriptors and the Results of Short-Term Biological Assays

Volume:14   Issue: 11
Pp: 1356-1364
Yen Sia Low, Alexander Yeugenyevich Sedykh, Ivan Rusyn and Alexander Tropsha
DOI: 10.2174/1568026614666140506121116
Published on: 06 May, 2014

Prediction of Cytochrome P450 Mediated Metabolism of Designer Drugs

Volume:14   Issue: 11
Pp: 1365-1373
Line Marie Nielsen, Kristian Linnet, Lars Olsen and Patrik Rydberg
DOI: 10.2174/1568026614666140506122202
Published on: 06 May, 2014

Mutagenicity of N-oxide Containing Heterocycles and Related Compounds: Experimental and Theoretical Studies

Volume:14   Issue: 11
Pp: 1374-1387
Martin Gabay, Mauricio Cabrera, Rossanna Di Maio, Juan A. Paez, Nuria Campillo, Maria L. Lavaggi, Hugo Cerecetto and Mercedes González
DOI: 10.2174/1568026614666140506123235
Published on: 06 May, 2014

In Vitro Microsomal Hepatic Metabolism of Antiasthmatic Prototype LASSBio-448

Volume:14   Issue: 11
Pp: 1388-1398
Isabelle Karine Costa Nunes, Luzineide Wanderley Tinoco, Helvecio Martins-Junior, Claudia Rezende, Eliezer J. Barreiro and Lidia Moreira Lima
DOI: 10.2174/1568026614666140506123718
Published on: 06 May, 2014

Tuning hERG Out: Antitarget QSAR Models for Drug Development

Volume:14   Issue: 11
Pp: 1399-1415
Rodolpho C. Braga, Vinicius M. Alves, Meryck F.B. Silva, Eugene Muratov, Denis Fourches, Alexander Tropsha and Carolina H. Andrade
DOI: 10.2174/1568026614666140506124442
Published on: 06 May, 2014

In Memory of Patrik Rydberg

Volume:14   Issue: 11
Pp: 1416-1416
Lars Olsen
DOI: 10.2174/156802661411140604123400
Published on: 04 June, 2014