Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 14 Issue: 10, May 2014

Editorial (Thematic Issue: Enantioselective Synthesis in Organic and Medicinal Chemistry) free to download

Volume:14   Issue: 10
Pp: 1209-1211
E. Lete, N. Sotomayor and S. Arrasate
DOI: 10.2174/1568026614666140423094623
Published on: 22 April, 2014

Recent Advances on the Enantioselective Synthesis of C-Nucleosides Inhibitors of Inosine Monophosphate Dehydrogenase (IMPDH)

Volume:14   Issue: 10
Pp: 1212-1224
Pedro Merino, Mattia Ghirardello, Tomas Tejero, Ignacio Delso and Rosa Matute
DOI: 10.2174/1568026614666140423095331
Published on: 22 April, 2014

Conformational Preferences of Chiral Acyclic Homooligomeric β2,2-Peptides

Volume:14   Issue: 10
Pp: 1225-1234
Fernando Rodriguez, Francisco Corzana, Alberto Avenoza, Jesus Hector Busto, Jesus Manuel Peregrina and Maria del Mar Zurbano
DOI: 10.2174/1568026614666140423101226
Published on: 22 April, 2014

Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

Volume:14   Issue: 10
Pp: 1235-1243
Nuno M. Xavier and Amélia P. Rauter
DOI: 10.2174/1568026614666140423103848
Published on: 22 April, 2014

Chiral Thiazoline and Thiazole Building Blocks for the Synthesis of Peptide- Derived Natural Products

Volume:14   Issue: 10
Pp: 1244-1256
Xavier Just-Baringo, Fernando Albericio and Mercedes Alvarez
DOI: 10.2174/1568026614666140423105730
Published on: 22 April, 2014

Enantiopure 1,2,3-Triazolyl-β-amino Acids via Click Cycloaddition Reaction on Racemic Alkynyl Precursors Followed by Separation of Stereoisomers

Volume:14   Issue: 10
Pp: 1257-1270
Margarita Escudero-Casao, Alberto Vega-Penaloza and Eusebio Juaristi
DOI: 10.2174/1568026614666140423110420
Published on: 23 April, 2014

Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes

Volume:14   Issue: 10
Pp: 1271-1282
Carmen Nejera and Jose M. Sansano
DOI: 10.2174/1568026614666140423112145
Published on: 23 April, 2014

Enantioselective Synthesis of PPAR (Peroxisome Proliferator-Activated Receptors) Agonists and Antagonists

Volume:14   Issue: 10
Pp: 1283-1293
Pilar Goya, Ruth Perez-Fernandez, Rosario Gonzalez-Muniz and Jose Elguero
DOI: 10.2174/1568026614666140423112822
Published on: 23 April, 2014

Recent Syntheses and Biological Activity of Lentiginosine and its Analogues

Volume:14   Issue: 10
Pp: 1294-1307
Franca M. Cordero, Donatella Giomi and Alberto Brandi
DOI: 10.2174/1568026614666140423113226
Published on: 23 April, 2014

Stereoselective Synthesis of Polysubstituted Piperazines and Oxopiperazines. Useful Building Blocks in Medicinal Chemistry

Volume:14   Issue: 10
Pp: 1308-1316
Alessandro Mordini, Gianna Reginato, Massimo Calamante and Lorenzo Zani
DOI: 10.2174/1568026614666140423114013
Published on: 23 April, 2014

Base Free Catalyzed Enantioselective Michael Reaction of bis(phenylsulfonyl)methane to α,β -Unsaturated Aldehydes under Iminium Activation

Volume:14   Issue: 10
Pp: 1317-1322
Beatriz Alonso, Uxue Uria, Luisa Carrillo, Jose L. Vicario and Efraim Reyes
DOI: 10.2174/1568026614666140423114516
Published on: 23 April, 2014