Current Topics in Medicinal Chemistry


Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA

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Editorial (Hot Topic: Protein Misfolding in Conformational Disorders) free to download

Volume:12   Issue: 22
Pp: 2459-2459
Claudio M. Gomes
DOI: 10.2174/1568026611212220001

Protein Misfolding in Disease and Small Molecule Therapies open access plus

Volume:12   Issue: 22
Pp: 2460-2469
Claudio M. Gomes
DOI: 10.2174/1568026611212220002

Aggregation Prone Regions and Gatekeeping Residues in Protein Sequences

Volume:12   Issue: 22
Pp: 2470-2478
Jacinte Beerten, Joost Schymkowitz and Frederic Rousseau
DOI: 10.2174/1568026611212220003

DNAJ Proteins and Protein Aggregation Diseases

Volume:12   Issue: 22
Pp: 2479-2490
Vaishali Kakkar, Louis C. B. Prins and Harm H. Kampinga
DOI: 10.2174/1568026611212220004

Molecular Chaperone Disorders: Defective Hsp60 in Neurodegeneration

Volume:12   Issue: 22
Pp: 2491-2503
Peter Bross, Raffaella Magnoni and Anne Sigaard Bie
DOI: 10.2174/1568026611212220005

On the Design of Broad Based Screening Assays to Identify Potential Pharmacological Chaperones of Protein Misfolding Diseases

Volume:12   Issue: 22
Pp: 2504-2522
Subhashchandra Naik, Na Zhang, Phillip Gao and Mark T. Fisher
DOI: 10.2174/1568026611212220006

Amyloid Formation in Light Chain Amyloidosis

Volume:12   Issue: 22
Pp: 2523-2533
Marina Ramirez-Alvarado
DOI: 10.2174/1568026611212220007

Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones open access plus

Volume:12   Issue: 22
Pp: 2534-2545
Jarl Underhaug, Oscar Aubi and Aurora Martinez
DOI: 10.2174/1568026611212220008

Cofactors and Metabolites as Protein Folding Helpers in Metabolic Diseases

Volume:12   Issue: 22
Pp: 2546-2559
Joao V. Rodrigues, Barbara J. Henriques, Tania G. Lucas and Claudio M. Gomes
DOI: 10.2174/1568026611212220009

SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status open access plus

Volume:12   Issue: 22
Pp: 2560-2572
Yuewei Sheng, Madhuri Chattopadhyay, Julian Whitelegge and Joan Selverstone Valentine
DOI: 10.2174/1568026611212220010

Copper and Heme-Mediated Abeta Toxicity: Redox Chemistry, Abeta Oxidations and Anti-ROS Compounds

Volume:12   Issue: 22
Pp: 2573-2595
Stefan Chassaing, Fabrice Collin, Pierre Dorlet, Jerome Gout, Christelle Hureau and Peter Faller
DOI: 10.2174/1568026611212220011

Insights into Aβ Aggregation: A Molecular Dynamics Perspective

Volume:12   Issue: 22
Pp: 2596-2610
Joan-Emma Shea and Brigita Urbanc
DOI: 10.2174/1568026611212220012

Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation

Volume:12   Issue: 22
Pp: 2623-2640
Barbara Calamini and Richard I. Morimoto
DOI: 10.2174/1568026611212220014