Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 12 Issue: 15, August 2012

Editorial [Hot Topic: A New Era of Gene Therapy]

Volume:12   Issue: 15
Pp: 1593-1593
Jun-ichi Suzuki and Ryuichi Morishita
DOI: 10.2174/156802612803531441
Published on: 10 October, 2012

Novel Gene Transfer Systems: Intelligent Gene Transfer Vectors for Gene Medicines open access plus

Volume:12   Issue: 15
Pp: 1594-1602
Toshihiro Nakajima
DOI: 10.2174/156802612803531487
Published on: 10 October, 2012

Modification of Decoy Oligodeoxynucleotides to Achieve the Stability and Therapeutic Efficacy

Volume:12   Issue: 15
Pp: 1603-1607
Mariana Kiomy Osako, Hironori Nakagami and Ryuichi Morishita
DOI: 10.2174/156802612803531397
Published on: 10 October, 2012

Applications of Nucleic Acid Drugs for Organ Transplantation

Volume:12   Issue: 15
Pp: 1608-1612
Jun-ichi Suzuki, Mitsuaki Isobe, Ryuichi Morishita and Ryozo Nagai
DOI: 10.2174/156802612803531478
Published on: 10 October, 2012

Nucleic Acid Drugs for Preventing Restenosis after Coronary Revascularization

Volume:12   Issue: 15
Pp: 1613-1620
Takashi Miyake, Hironori Nakagami and Ryuichi Morishita
DOI: 10.2174/156802612803531324
Published on: 10 October, 2012

Development of Nucleic Acid Drugs for Neurological Disorders

Volume:12   Issue: 15
Pp: 1621-1629
Munehisa Shimamura, Naoyuki Sato, Hironori Nakagami, Yoshiaki Taniyama and Ryuichi Morishita
DOI: 10.2174/156802612803531405
Published on: 10 October, 2012

Therapeutic Option of Plasmid-DNA Based Gene Transfer

Volume:12   Issue: 15
Pp: 1630-1637
Yoshiaki Taniyama, Junya Azuma, Yasuo Kunugiza, Kazuma Iekushi, Hiromi Rakugi and Ryuichi Morishita
DOI: 10.2174/156802612803531342
Published on: 10 October, 2012

Editorial [Hot Topic: Targeted Therapy, Targeted Dosing and Targeted Delivery in Oncology: Where Do We Stand?]

Volume:12   Issue: 15
Pp: 1638-1638
Joseph Ciccolini
DOI: 10.2174/156802612803531379
Published on: 10 October, 2012

Can Targeted Therapy be Successful without Metronomic Scheduling ?

Volume:12   Issue: 15
Pp: 1639-1642
Nicolas Andre, Eddy Pasquier and Barton Kamen
DOI: 10.2174/156802612803531432
Published on: 10 October, 2012

100% Human Monoclonal Antibodies in Oncology: Hype or Breakthrough?

Volume:12   Issue: 15
Pp: 1643-1648
Stephan Benay, Raphaelle Fanciullino, Cedric Mercier, Athanassios Iliadis, Joseph Ciccolini and Bruno Lacarelle
DOI: 10.2174/156802612803531351
Published on: 10 October, 2012

Polymorphisms to Predict Outcome to the Tyrosine Kinase Inhibitors Gefitinib, Erlotinib, Sorafenib and Sunitinib

Volume:12   Issue: 15
Pp: 1649-1659
Lale Erdem, Elisa Giovannetti, Leticia G Leon, Richard Honeywell and Godefridus J. Peters
DOI: 10.2174/156802612803531333
Published on: 10 October, 2012

A New Model for Determining the MTD During Phase-I Trials in Pediatric Oncology

Volume:12   Issue: 15
Pp: 1660-1664
C. Faivre, D. Barbolosi and A. Iliadis
DOI: 10.2174/156802612803531469
Published on: 10 October, 2012

Optimize Administration Protocol of Capecitabine Plus Docetaxel Combination in Metastatic Breast Cancer Patients

Volume:12   Issue: 15
Pp: 1665-1668
Nicolas Frances, Christian Woloch, Hafedh Marouani, Cedric Mercier and Athanassios Iliadis
DOI: 10.2174/156802612803531306
Published on: 10 October, 2012

Progress in Strategies for Dosage Regimen Individualization

Volume:12   Issue: 15
Pp: 1669-1677
Hafedh Marouani, Christian Woloch, Stephan Benay, Nicolas Frances and Athanassios Iliadis
DOI: 10.2174/156802612803531315
Published on: 10 October, 2012

Targetting Esophageal and Gastric Cancers with Monoclonal Antibodies

Volume:12   Issue: 15
Pp: 1678-1682
Emmanuelle Norguet, Laetitia Dahan and Jean-Francois Seitz
DOI: 10.2174/156802612803531360
Published on: 10 October, 2012

Search for Distinctive Markers in DNT and Cortical Grade II Glioma in Children: Same Clinicopathological and Molecular Entities?

Volume:12   Issue: 15
Pp: 1683-1692
Laetitia Padovani, Carole Colin, Carla Fernandez, Andre Maues de Paula, Sandy Mercurio, Didier Scavarda, Frederic Frassineti, Jose Adelaide, Anderson Loundou, Dominique Intagliata, Corinne Bouvier, Gabriel Lena, Daniel Birnbaum, Nadine Girard and Dominique Figarella-Branger
DOI: 10.2174/156802612803531450
Published on: 10 October, 2012

Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy open access plus

Volume:12   Issue: 15
Pp: 1693-1712
Giorgia Urbinati, Veronique Marsaud and Jack-Michel Renoir
DOI: 10.2174/156802612803531423
Published on: 10 October, 2012

Population Pharmacokinetic Analysis of 5-FU and 5-FDHU in Colorectal Cancer Patients: Search for Biomarkers Associated with Gastro-Intestinal Toxicity

Volume:12   Issue: 15
Pp: 1713-1719
Christian Woloch, Antonello Di Paolo, Hafedh Marouani, Guido Bocci, Joseph Ciccolini, Bruno Lacarelle, Romano Danesi and Athanassios Iliadis
DOI: 10.2174/156802612803531414
Published on: 10 October, 2012

Genetic Polymorphisms of Drug Metabolizing Enzymes and Transporters: The Long Way from Bench to Bedside

Volume:12   Issue: 15
Pp: 1720-1729
Alexandre Evrard and Litaty Mbatchi
DOI: 10.2174/156802612803531388
Published on: 10 October, 2012