Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 11 Issue: 6, March

Editorial [Hot topic: G-Protein Coupled Receptors: Drug Targets of Key Importance (Guest Editors: Luca Piali and Christoph Boss)]

Volume:11   Issue: 6
Pp: 608-608
Luca Piali and Christoph Boss
DOI: 10.2174/1568026611109060608
Published on: 01 March, 2012

The Role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression: Therapeutic Implications

Volume:11   Issue: 6
Pp: 609-617
R. Brett Lloyd and Charles B. Nemeroff
DOI: 10.2174/1568026611109060609
Published on: 01 March, 2012

EBI2, GPR18, and GPR17 – Three Structurally Related but Biologically Distinct 7TM Receptors

Volume:11   Issue: 6
Pp: 618-628
Kristine Norregaard, Tau Benned-Jensen and Mette Marie Rosenkilde
DOI: 10.2174/1568026611109060618
Published on: 01 March, 2012

Novel Anti-Inflammatory-Pro-Resolving Mediators and Their Receptors

Volume:11   Issue: 6
Pp: 629-647
Charles N. Serhan, Sriram Krishnamoorthy, Antonio Recchiuti and Nan Chiang
DOI: 10.2174/1568026611109060629
Published on: 01 March, 2012

The Evolution of Histamine H3 Antagonists/Inverse Agonists

Volume:11   Issue: 6
Pp: 648-660
Evan P. Lebois, Carrie K. Jones and Craig W. Lindsley
DOI: 10.2174/1568026611109060648
Published on: 01 March, 2012

Molecular Determinants of Selective Agonist and Antagonist Binding to the Histamine H4 Receptor

Volume:11   Issue: 6
Pp: 661-679
Enade P. Istyastono, Chris de Graaf, Iwan J.P. de Esch and Rob Leurs
DOI: 10.2174/1568026611109060661
Published on: 01 March, 2012

mGluR5 Negative Allosteric Modulators Overview: A Medicinal Chemistry Approach Towards a Series of Novel Therapeutic Agents

Volume:11   Issue: 6
Pp: 680-695
Jean-Philippe Rocher, Beatrice Bonnet, Christelle Bolea, Robert Lutjens, Emmanuel Le Poul, Sonia Poli, Mark Epping-Jordan, Anne-Sophie Bessis, Bernard Ludwig and Vincent Mutel
DOI: 10.2174/1568026611109060680
Published on: 01 March, 2012

Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia

Volume:11   Issue: 6
Pp: 696-725
Paul J. Coleman, Christopher D. Cox and Anthony J. Roecker
DOI: 10.2174/1568026611109060696
Published on: 01 March, 2012

Synthetic Sphingosine 1-Phosphate Receptor Modulators - Opportunities and Potential Pitfalls

Volume:11   Issue: 6
Pp: 726-757
Martin H. Bolli, Cyrille Lescop and Oliver Nayler
DOI: 10.2174/1568026611109060726
Published on: 01 March, 2012