Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Editorial [Hot topic: Drug Design from the ADME/PK Perspective: Does Chemical Intuition Suffice in Multifaceted Drug Discovery? (Guest Editors: Franco Lombardo & Nigel J. Waters)] promotion: free to download

Volume:11   Issue: 4
Pp: 331-333
F. Lombardo and Nigel J. Waters
DOI: 10.2174/156802611794480936

Predicting Clearance in Humans from In Vitro Data

Volume:11   Issue: 4
Pp: 334-339
R. Scott Obach
DOI: 10.2174/156802611794480873

In-Silico ADME Models: A General Assessment of their Utility in Drug Discovery Applications

Volume:11   Issue: 4
Pp: 358-381
M. Paul Gleeson, Anne Hersey and Supa Hannongbua
DOI: 10.2174/156802611794480927

Pharmacodynamic-Pharmacokinetic Integration as a Guide to Medicinal Chemistry

Volume:11   Issue: 4
Pp: 404-418
Johan Gabrielsson, Ola Fjellstrom, Johan Ulander, Michael Rowley and Piet H. Van Der Graaf
DOI: 10.2174/156802611794480864

Strategies and Chemical Design Approaches to Reduce the Potential for Formation of Reactive Metabolic Species

Volume:11   Issue: 4
Pp: 419-449
Upendra A. Argikar, James B. Mangold and Shawn P. Harriman
DOI: 10.2174/156802611794480891

Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery?

Volume:11   Issue: 4
Pp: 450-466
Xingrong Liu, Cuiping Chen and Cornelis E.C.A. Hop
DOI: 10.2174/156802611794480918

Discovery and ADMET: Where Are We Now

Volume:11   Issue: 4
Pp: 467-481
Dennis A. Smith
DOI: 10.2174/156802611794480909