Current Topics in Medicinal Chemistry

Editor-in-Chief

Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)

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Volume: 11 Issue: 2, January

Editorial [Hot topic: Applying Induced Fit in Drug Discovery: Square Pegs and Round Holes? (Guest Editors: Francesca Spyrakis, Pietro Cozzini, Aurijit Sarkar and Glen E. Kellogg)]

Volume:11   Issue: 2
Pp: 131-132
Francesca Spyrakis, Pietro Cozzini, Aurijit Sarkar and Glen E. Kellogg
DOI: 10.2174/156802611794863553
Published on: 01 March, 2012

Induced Fit Simulations on Nuclear Receptors

Volume:11   Issue: 2
Pp: 133-147
Monika Nocker and Pietro Cozzini
DOI: 10.2174/156802611794863526
Published on: 01 March, 2012

Biochemical and Structural Investigations on Kynurenine Aminotransferase II: An Example of Conformation-Driven Species-Specific Inhibition?

Volume:11   Issue: 2
Pp: 148-157
Valentina Casazza, Franca Rossi and Menico Rizzi
DOI: 10.2174/156802611794863599
Published on: 01 March, 2012

Ligands Turning Around in the Midst of Protein Conformers: The Origin of Ligand-Protein Mating. A NMR View

Volume:11   Issue: 2
Pp: 158-170
T. A. Pertinhez and A. Spisni
DOI: 10.2174/156802611794863535
Published on: 01 March, 2012

Accommodating Protein Flexibility for Structure-Based Drug Design

Volume:11   Issue: 2
Pp: 171-178
Jung-Hsin Lin
DOI: 10.2174/156802611794863580
Published on: 01 March, 2012

Accounting for Induced-Fit Effects in Docking: What is Possible and What is Not?

Volume:11   Issue: 2
Pp: 179-191
Christoph A. Sotriffer
DOI: 10.2174/156802611794863544
Published on: 01 March, 2012

Protein Flexibility and Ligand Recognition: Challenges for Molecular Modeling

Volume:11   Issue: 2
Pp: 192-210
Francesca Spyrakis, Axel BidonChanal, Xavier Barril and F. Javier Luque
DOI: 10.2174/156802611794863571
Published on: 01 March, 2012

Thermal Motions of the E. coli Glucose-Galactose Binding Protein Studied Using Well-Sampled Semi-Atomistic Simulations

Volume:11   Issue: 2
Pp: 211-220
D. J. Cashman, A. B. Mamonov, D. Bhatt and D. M. Zuckerman
DOI: 10.2174/156802611794863607
Published on: 01 March, 2012

Melatonin-mitochondria Interplay in Health and Disease

Volume:11   Issue: 2
Pp: 221-240
Dario Acuna Castroviejo, Luis C. Lopez, Germaine Escames, Ana Lopez, Jose A. Garcia and Russel J. Reiter
DOI: 10.2174/156802611794863517
Published on: 01 March, 2012

A Closer Look at the High Affinity Benzodiazepine Binding Site on GABAA Receptors

Volume:11   Issue: 2
Pp: 241-246
Erwin Sigel and Benjamin P. Luscher
DOI: 10.2174/156802611794863562
Published on: 01 March, 2012