Current Topics in Medicinal Chemistry

Editor-in-Chief

Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)

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Volume: 11 Issue: 15, August

Editorial [Hot Topic: Methods for the Successful Application of Chemogenomics to GPCR Drug Design (Guest Editors: Stephen L. Garland & David E. Gloriam)]

Volume:11   Issue: 15
Pp: 1870-1871
Stephen L. Garland and David E. Gloriam
DOI: 10.2174/156802611796391294
Published on: 01 March, 2012

A Ligands View of Target Similarity: Chemogenomic Binding Site- Directed Techniques for Drug Discovery

Volume:11   Issue: 15
Pp: 1872-1881
Stephen L. Garland and David E. Gloriam
DOI: 10.2174/156802611796391276
Published on: 01 March, 2012

Drug Design of GPCR Ligands Using Physicogenetics and Chemogenomics - Principles and Case Studies

Volume:11   Issue: 15
Pp: 1882-1901
Thomas M. Frimurer and Thomas Hogberg
DOI: 10.2174/156802611796391258
Published on: 01 March, 2012

G Protein-Coupled Receptor Transmembrane Binding Pockets and their Applications in GPCR Research and Drug Discovery: A Survey

Volume:11   Issue: 15
Pp: 1902-1924
Nicole A. Kratochwil, Silvia Gatti-McArthur, Marius C. Hoener, Lothar Lindemann, Andreas D. Christ, Luke G. Green, Wolfgang Guba, Rainer E. Martin, Pari Malherbe, Richard H. P. Porter, Jay P. Slack, Marcel Winnig, Henrietta Dehmlow, Uwe Grether, Cornelia Hertel, Robert Narquizian, Constantinos G. Panousis, Sabine Kolczewski and Lucinda Steward
DOI: 10.2174/156802611796391267
Published on: 01 March, 2012

Thematic Analysis™ : A Chemogenomic Approach to GPCR Drug Discovery

Volume:11   Issue: 15
Pp: 1925-1943
Roger Crossley, Jacqueline Anne Macritchie and Martin John Slater
DOI: 10.2174/156802611796391302
Published on: 01 March, 2012

Chemogenomic Approaches for the Exploration of GPCR Space

Volume:11   Issue: 15
Pp: 1944-1955
Nathanael Weill
DOI: 10.2174/156802611796391212
Published on: 01 March, 2012

Cross-Pharmacology Analysis of G Protein-Coupled Receptors

Volume:11   Issue: 15
Pp: 1956-1963
Ferran Brianso, Maria C. Carrascosa, Tudor I. Oprea and Jordi Mestres
DOI: 10.2174/156802611796391285
Published on: 01 March, 2012

Chemogenomics Approaches for Receptor Deorphanization and Extensions of the Chemogenomics Concept to Phenotypic Space

Volume:11   Issue: 15
Pp: 1964-1977
Eelke van der Horst, Julio E. Peironcely, Gerard J. P. van Westen, Olaf O. van den Hoven, Warren R. J. D. Galloway, David R. Spring, Joerg K. Wegner, Herman W. T. van Vlijmen, Ad P. IJzerman, John P. Overington and Andreas Bender
DOI: 10.2174/156802611796391230
Published on: 01 March, 2012

Quantitative Chemogenomics: Machine-Learning Models of Protein-Ligand Interaction

Volume:11   Issue: 15
Pp: 1978-1993
Claes R. Andersson, Mats G. Gustafsson and Helena Strombergsson
DOI: 10.2174/156802611796391249
Published on: 01 March, 2012

Present Perspectives on the Automated Classification of the G-Protein Coupled Receptors (GPCRs) at the Protein Sequence Level

Volume:11   Issue: 15
Pp: 1994-2009
Matthew N. Davies, David E. Gloriam, Andrew Secker, Alex A. Freitas, Jon Timmis and Darren R. Flower
DOI: 10.2174/156802611796391221
Published on: 01 March, 2012