Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Volume: 10 Issue: 3, February

Editorial [Hot topic: The Medicinal Chemistry of Protease Inhibitors (Guest Editors: Wibke E. Diederich and Christof Wegscheid-Gerlach)]

Volume:10   Issue: 3
Pp: 231-231
Wibke E. Diederich and Christof Wegscheid-Gerlach
DOI: 10.2174/156802610790725443
Published on: 01 March, 2012

Proteasome Inhibitors: Recent Advances and New Perspectives In Medicinal Chemistry

Volume:10   Issue: 3
Pp: 232-256
E. Genin, M. Reboud-Ravaux and J. Vidal
DOI: 10.2174/156802610790725515
Published on: 01 March, 2012

Entering the Era of Non-Basic P1 Site Groups: Discovery of Xarelto™ (Rivaroxaban)

Volume:10   Issue: 3
Pp: 257-269
Alexander Straub, Susanne Roehrig and Alexander Hillisch
DOI: 10.2174/156802610790725506
Published on: 01 March, 2012

Calpains: Attractive Targets for the Development of Synthetic Inhibitors

Volume:10   Issue: 3
Pp: 270-293
Markus Pietsch, Krystle C. H. Chua and Andrew D. Abell
DOI: 10.2174/156802610790725489
Published on: 01 March, 2012

Development of Nitrile-Based Peptidic Inhibitors of Cysteine Cathepsins

Volume:10   Issue: 3
Pp: 294-322
Maxim Frizler, Marit Stirnberg, Mihiret Tekeste Sisay and Michael Gutschow
DOI: 10.2174/156802610790725452
Published on: 01 March, 2012

Recent Advances in Targeting Viral Proteases for the Discovery of Novel Antivirals

Volume:10   Issue: 3
Pp: 323-345
Holger Steuber and Rolf Hilgenfeld
DOI: 10.2174/156802610790725470
Published on: 01 March, 2012

Proteases of Plasmodium falciparum as Potential Drug Targets and Inhibitors Thereof

Volume:10   Issue: 3
Pp: 346-367
Christof Wegscheid-Gerlach, Hans-Dieter Gerber and Wibke E. Diederich
DOI: 10.2174/156802610790725461
Published on: 01 March, 2012

Enzyme Kinetics and Hit Validation in Fluorimetric Protease Assays

Volume:10   Issue: 3
Pp: 368-382
Stephanie Ludewig, Markus Kossner, Markus Schiller, Knut Baumann and Tanja Schirmeister
DOI: 10.2174/156802610790725498
Published on: 01 March, 2012