Current Topics in Medicinal Chemistry

Editor-in-Chief

Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)

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Volume: 10 Issue: 17, December

Editorial [Hot topic: Imaging of ABC Transporter Function and Expression (Guest Editors: Nicola Antonio Colabufo and Aren van Waarde)]

Volume:10   Issue: 17
Pp: 1701-1702
Nicola Antonio Colabufo and Aren van Waarde
DOI: 10.2174/156802610792928068
Published on: 01 March, 2012

Substrates, Inhibitors and Activators of P-glycoprotein: Candidates for Radiolabeling and Imaging Perspectives

Volume:10   Issue: 17
Pp: 1703-1714
Nicola A. Colabufo, Francesco Berardi, Maria Grazia Perrone, Elena Capparelli, Mariangela Cantore, Carmela Inglese and Roberto Perrone
DOI: 10.2174/156802610792928022
Published on: 01 March, 2012

N,N-bis(Cyclohexanol)amine Aryl Esters: The Discovery of a New Class of Highly Potent Inhibitors of Transporter-Dependent Multidrug Resistance (MDR)

Volume:10   Issue: 17
Pp: 1715-1731
E. Teodori, S. Dei, C. Martelli and S. Scapecchi
DOI: 10.2174/156802610792928031
Published on: 01 March, 2012

Modulators of Multidrug Resistance Proteins in the Management of Anticancer and Antimicrobial Drug Resistance and the Treatment of Inflammatory Diseases

Volume:10   Issue: 17
Pp: 1732-1756
An-Kui Yang, Zhi-Wei Zhou, Min-Qian Wei, Jun-Ping Liu and Shu-Feng Zhou
DOI: 10.2174/156802610792928040
Published on: 01 March, 2012

Reversal of Multidrug Resistance by Natural Substances from Plants

Volume:10   Issue: 17
Pp: 1757-1768
Q. Wang, K. Michalak, O. Wesolowska, J. Deli, P. Molnar, J. Hohmann, J. Molnar and H. Engi
DOI: 10.2174/156802610792928103
Published on: 01 March, 2012

Using Structural and Mechanistic Information to Design Novel Inhibitors/Substrates of P-Glycoprotein

Volume:10   Issue: 17
Pp: 1769-1774
Freya Klepsch, Thomas Stockner, Thomas Erker, Markus Muller, Peter Chiba and Gerhard F. Ecker
DOI: 10.2174/156802610792928004
Published on: 01 March, 2012

11C-verapamil to Assess P-gp Function in Human Brain During Aging,Depression and Neurodegenerative Disease

Volume:10   Issue: 17
Pp: 1775-1784
A. L. Bartels, O. L. de Klerk, R. Kortekaas, J. J. de Vries and K. L. Leenders
DOI: 10.2174/156802610792928059
Published on: 01 March, 2012

Imaging of P-glycoprotein Function and Expression to Elucidate Mechanisms of Pharmacoresistance in Epilepsy

Volume:10   Issue: 17
Pp: 1785-1791
Wolfgang Loscher and Oliver Langer
DOI: 10.2174/156802610792928095
Published on: 01 March, 2012

PET Imaging of Multidrug Resistance in Tumors Using 18F-Fluoropaclitaxel

Volume:10   Issue: 17
Pp: 1792-1798
Karen A. Kurdziel and Dale O. Kiesewetter
DOI: 10.2174/156802610792928077
Published on: 01 March, 2012

Using PET Studies of P-gp Function to Elucidate Mechanisms Underlying the Disposition of Drugs

Volume:10   Issue: 17
Pp: 1799-1809
Stina Syvanen and Margareta Hammarlund-Udenaes
DOI: 10.2174/156802610792927997
Published on: 01 March, 2012

PET Imaging of MRP1 Function in the Living Brain: Method Development and Future Perspectives

Volume:10   Issue: 17
Pp: 1810-1819
T. Okamura, T. Kikuchi and T. Irie
DOI: 10.2174/156802610792927988
Published on: 01 March, 2012

Carbon-11 Labeled Tracers for In Vivo Imaging of P-Glycoprotein Function: Kinetics, Advantages and Disadvantages

Volume:10   Issue: 17
Pp: 1820-1833
Gert Luurtsema, Joost Verbeek, Mark Lubberink, Adriaan A. Lammertsma, Rudi Dierckx, Philip Elsinga, Albert D. Windhorst and Aren van Waarde
DOI: 10.2174/156802610792928013
Published on: 01 March, 2012

Probing Multidrug Resistance P-glycoprotein Transporter Activity with SPECT Radiopharmaceuticals

Volume:10   Issue: 17
Pp: 1834-1845
David Piwnica-Worms and Vijay Sharma
DOI: 10.2174/156802610792928086
Published on: 01 March, 2012