Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Editor's Choice

Parallelization of Molecular Docking: A Review

Volume: 18   Issue: 12
Pp: 1015-1028
Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*
DOI: 10.2174/1568026618666180821145215

A Review on Plant Antimicrobials of Past Decade

Volume: 18   Issue: 10
Pp: 812-833
Preet Amol Singh, Sapna D. Desai and Jasbir Singh*
DOI: 10.2174/1568026618666180516123229

Emerging Virulence, Drug Resistance and Future Anti-fungal Drugs for Candida Pathogens

Volume: 18   Issue: 9
Pp: 759-778
Vartika Srivastava, Rajeev Kumar Singla and Ashok Kumar Dubey*
DOI: 10.2174/1568026618666180528121707

Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

Volume: 18   Issue: 8
Pp: 714-746
Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*
DOI: 10.2174/1568026618666180604082610

Backbone-Cyclized Peptides: A Critical Review

Volume: 18   Issue: 7
Pp: 526-555
Samuel J.S. Rubin and Nir Qvit*
DOI: 10.2174/1568026618666180518092333

Polyamines and Related Nitrogen Compounds in the Chemotherapy of Neglected Diseases Caused by Kinetoplastids

Volume: 18   Issue: 5
Pp: 321-368
Juan A. Bisceglia*, Maria C. Mollo, Nadia Gruber and Liliana R. Orelli*
DOI: 10.2174/1568026618666180427151338

Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

Volume: 18   Issue: 4
Pp: 256-274
Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao
DOI: 10.2174/1568026618666180410151518

Aurora Kinase Inhibitors in Head and Neck Cancer

Volume: 18   Issue: 3
Pp: 199-213
Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*
DOI: 10.2174/1568026618666180112163741

Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years

Volume: 18   Issue: 2
Pp: 124-148
Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*
DOI: 10.2174/1568026618666180329115523

New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation

Volume: 18   Issue: 1
Pp: 75-87
Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric
DOI: 10.2174/1568026618666180206101814

The Glitter of Carbon Nanostructures in Hybrid/Composite Hydrogels for Medicinal Use

Volume: 16   Issue: 18
Pp: 1976-1989
Daniel Iglesias, Susanna Bosi, Michele Melchionna, Tatiana Da Ros and Silvia Marchesan
DOI: 10.2174/1568026616666160215154807

Resveratrol as a Potential Therapeutic Candidate for the Treatment and Management of Alzheimer's Disease

Volume: 16   Issue: 17
Pp: 1951-1960
Nady Braidy, Bat-Erdene Jugder, Anne Poljak, Tharusha Jayasena, Hussein Mansour, Seyed Mohammad Nabavi, Perminder Sachdev and Ross Grant
DOI: 10.2174/1568026616666160204121431

Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation

Volume: 16   Issue: 16
Pp: 1792-1818
Robert A. Pearlstein, K. Andrew MacCannell, Gül Erdemli, Sarita Yeola, Gabriel Helmlinger, Qi-Ying Hu, Ramy Farid, William Egan, Steven Whitebread, Clayton Springer, Jeremy Beck, Hao-Ran Wang, Mateusz Maciejewski, Laszlo Urban and José S. Duca
DOI: 10.2174/1568026616666160315142156

Using Genomics for Natural Product Structure Elucidation

Volume: 16   Issue: 15
Pp: 1645-1694
Jonathan I. Tietz and Douglas A. Mitchell
DOI: 10.2174/1568026616666151012111439

Electronic Nose and Exhaled Breath NMR-based Metabolomics Applications in Airways Disease

Volume: 16   Issue: 14
Pp: 1610-1630
Giuseppe Santini, Nadia Mores, Andreu Penas, Rosamaria Capuano, Chiara Mondino, Andrea Trové, Francesco Macagno, Gina Zini, Paola Cattani, Eugenio Martinelli, Andrea Motta, Giuseppe Macis, Giovanni Ciabattoni and Paolo Montuschi
DOI: 10.2174/1568026616666151223113540

Current Drug Discovery for Anti-hepatitis C Virus Targeting NS4B

Volume: 16   Issue: 12
Pp: 1362-1371
Zhenya Wang, Xinli Chen, Chunli Wu, Haiwei Xu and Hongmin Liu
DOI: 10.2174/1568026616666151120112642

Bispidine as a Privileged Scaffold

Volume: 16   Issue: 11
Pp: 1314-1342
Isabelle Tomassoli and Daniela Gündisch
DOI: 10.2174/1568026615666150915111434

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41

Volume: 16   Issue: 10
Pp: 1074-1090
Lu Lu, Fei Yu, Lifeng Cai, Asim K. Debnath and Shibo Jiang
DOI: 10.2174/1568026615666150901114527

Systems Biology Approaches to a Rational Drug Discovery Paradigm

Volume: 16   Issue: 9
Pp: 1009-1025
Philip Prathipati and Kenji Mizuguchi
DOI: 10.2174/1568026615666150826114524

Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers

Volume: 16   Issue: 7
Pp: 697-713
Anne Yuqing Yang, Hyuck Kim, Wenji Li and Ah-Ng Tony Kong
DOI: 10.2174/1568026615666150826114359

Advances in Bacterial Methionine Aminopeptidase Inhibition

Volume: 16   Issue: 4
Pp: 397-414
Travis R. Helgren, Phumvadee Wangtrakuldee, Bart L. Staker and Timothy J. Hagen
DOI: 10.2174/1568026615666150813145410

Improving Peptide Applications Using Nanotechnology

Volume: 16   Issue: 3
Pp: 253-270
Radhika Narayanaswamy, Tao Wang and Vladimir P. Torchilin
DOI: 10.2174/1568026615666150817100338

Lanreotide and its Potential Applications in Polycystic Kidney and Liver Diseases

Volume: 16   Issue: 2
Pp: 133-140
Lichun Sun, Cui-Yun Yu, L. Vienna Mackey and David H. Coy
DOI: 10.2174/1568026615666150701115157

Mammalian Antimicrobial Peptides: Promising Therapeutic Targets Against Infection and Chronic Inflammation promotion: free to download

Volume: 16   Issue: 1
Pp: 99-129
Pujarini Dutta and Santasabuj Das
DOI: 10.2174/1568026615666150703121819

Discovery of GPCR Ligands by Molecular Docking Screening: Novel Opportunities Provided by Crystal Structures

Volume: 15   Issue: 24
Pp: 2484-2503
David Rodríguez, Anirudh Ranganathan and Jens Carlsson
DOI: 10.2174/1568026615666150701112853

An Overview of Recent Dipeptidyl Peptidase-IV Inhibitors: Linking their Structure and Physico-Chemical Properties with SAR, Pharmacokinetics and Toxicity

Volume: 15   Issue: 23
Pp: 2342-2372
Andrija Smelcerovic, Filip Miljkovic, Ana Kolarevic, Jelena Lazarevic, Aleksandra Djordjevic, Gordana Kocic and Marko Anderluh
DOI: 10.2174/1568026615666150619142731

Peptide Self-Assemblies for Drug Delivery

Volume: 15   Issue: 22
Pp: 2277-2289
Diana M. Leite, Eugen Barbu, Geoffrey J. Pilkington and Aikaterini Lalatsa
DOI: 10.2174/1568026615666150605120456

Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration

Volume: 15   Issue: 21
Pp: 2116-2138
Caio Henrique Mazucanti, Joao Victor Cabral-Costa, Andrea Rodrigues Vasconcelos, Diana Zukas Andreotti, Cristoforo Scavone and Elisa Mitiko Kawamoto
DOI: 10.2174/1568026615666150610125715

From Protein Communication to Drug Discovery

Volume: 15   Issue: 20
Pp: 2019-2031
Marco Persico, Antonio Di Dato, Nausicaa Orteca, Caterina Fattorusso, Ettore Novellino, Mirko Andreoli and Cristiano Ferlini
DOI: 10.2174/1568026615666150519102257

Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins

Volume: 15   Issue: 19
Pp: 1971-1987
Jun Qiu, Mingxue Wang, Yan Zhang, Ping Zeng, Tian-Miao Ou, Jia-Heng Tan, Shi-Liang Huang, Lin-Kun An, Honggen Wang, Lian-Quan Gu, Zhi-Shu Huang and Ding Li
DOI: 10.2174/1568026615666150515150803

Computer-Aided Drug Design of Bioactive Natural Products open access plus

Volume: 15   Issue: 18
Pp: 1780-1800
Veda Prachayasittikul, Apilak Worachartcheewan, Watshara Shoombuatong, Napat Songtawee, Saw Simeon, Virapong Prachayasittikul and Chanin Nantasenamat
DOI: 10.2174/1568026615666150506151101

Magnetite: From Synthesis to Applications

Volume: 15   Issue: 16
Pp: 1622-1640
Gozde Unsoy, Ufuk Gunduz, Ovidiu Oprea, Denisa Ficai, Maria Sonmez, Marius Radulescu, Mihaela Alexie and Anton Ficai
DOI: 10.2174/1568026615666150414153928

Smart Synthetic Polymer Nanocarriers for Controlled and Site-Specific Drug Delivery

Volume: 15   Issue: 15
Pp: 1424-1490
Paul Catalin Balaure and Alexandru Mihai Grumezescu
DOI: 10.2174/1568026615666150414115852

Therapeutic Agents Based on DNA Sequence Specific Binding

Volume: 15   Issue: 14
Pp: 1293-1322
Luke Pett, John A. Hartley and Konstantinos Kiakos
DOI: 10.2174/1568026615666150413155431

Interlocked Systems in Nanomedicine

Volume: 15   Issue: 13
Pp: 1236-1256
Catia Ornelas-Megiatto, Tiago B. Becher and Jackson D. Megiatto
DOI: 10.2174/1568026615666150330111614

Aptamers Overview: Selection, Features and Applications

Volume: 15   Issue: 12
Pp: 1066-1081
Luiza I. Hernandez, Isabel Machado, Thomas Schafer and Frank J. Hernandez
DOI: 10.2174/1568026615666150413153717

Dopamine D3 Agonists in the Treatment of Parkinson's Disease

Volume: 15   Issue: 10
Pp: 908-926
Banibrata Das, Gyan Modi and Aloke Dutta
DOI: 10.2174/156802661510150328223428

Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

Volume: 15   Issue: 9
Pp: 830-849
Iveta Najmanova, Martin Dosedel, Radomir Hrdina, Pavel Anzenbacher, Tomas Filipsky, Michal Riha and Premysl Mladenka
DOI: 10.2174/1568026615666150220112437

Autophagy Regulators as Potential Cancer Therapeutic agents: A Review

Volume: 15   Issue: 8
Pp: 720-744
Shan Li, Lingfei Wang, Yongzhou Hu and Rong Sheng
DOI: 10.2174/1568026615666150302105343

Organic Toxins as Tools to Understand Ion Channel Mechanisms and Structure

Volume: 15   Issue: 7
Pp: 581-603
Sara Luz Morales-Lazaro, Enrique Hernandez-Garcia, Barbara Serrano-Flores and Tamara Rosenbaum
DOI: 10.2174/1568026615666150217110710

Resonant Oscillation Language of a Futuristic Nano-Machine-Module: Eliminating Cancer Cells & Alzheimer Aβ Plaques

Volume: 15   Issue: 6
Pp: 534-541
Subrata Ghosh, Somnath Chatterjee, Anirban Roy, Kanad Ray, Snehasikta Swarnakar, Daisuke Fujita and Anirban Bandyopadhyay
DOI: 10.2174/1568026615666150225101155

Antioxidant Effects of Coumarins Include Direct Radical Scavenging, Metal Chelation and Inhibition of ROS-Producing Enzymes

Volume: 15   Issue: 5
Pp: 415-431
Tomas Filipsky, Michal Riha, Katerina Macakova, Eva Anzenbacherova, Jana Karlickova and Premysl Mladenka
DOI: 10.2174/1568026615666150206152233

Molecularly Imprinted Sol-Gel Materials for Medical Applications

Volume: 15   Issue: 3
Pp: 199-222
Riccardo Concu, Mariana Ornelas and Manuel Azenha
DOI: 10.2174/1568026614666141229112246

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

Volume: 15   Issue: 2
Pp: 163-169
Elzbieta Miller, Agnieszka Morel, Luciano Saso and Joanna Saluk
DOI: 10.2174/1568026615666141209160556

Computational and Experimental Advances in Drug Repositioning for Accelerated Therapeutic Stratification promotion: free to download

Volume: 15   Issue: 1
Pp: 5-20
Khader Shameer, Ben Readhead and Joel T. Dudley
DOI: 10.2174/1568026615666150112103510

The Medicinal Chemistry of Genus Aralia

Volume: 14   Issue: 24
Pp: 2783-2801
Jason A. Clement and Ella S.H. Clement
DOI: 10.2174/1568026615666141208110021

Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs

Volume: 14   Issue: 23
Pp: 2694-2711
Andres R. Alcantara, Vittorio Pace, Pilar Hoyos, Manuel Sandoval, Wolfgang Holzer and Maria J. Hernaiz
DOI: 10.2174/1568026614666141215151056

Selected Heterocyclic Compounds as Antioxidants. Synthesis and Biological Evaluation

Volume: 14   Issue: 22
Pp: 2462-2477
E. Tsolaki, P. Nobelos, A. Geronikaki and E.A. Rekka
DOI: 10.2174/1568026614666141203120425

Development of Vitamin D Analogs Modulating the Pocket Structure of Vitamin D Receptor

Volume: 14   Issue: 21
Pp: 2378-2387
Keiko Yamamoto, Yasuaki Anami and Toshimasa Itoh
DOI: 10.2174/156802661421141223091909

New Ligands of the Tubulin Colchicine Site Based on X-Ray Structures

Volume: 14   Issue: 20
Pp: 2231-2252
Raquel Alvarez, Manuel Medarde and Rafael Pelaez
DOI: 10.2174/1568026614666141130092637

Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands

Volume: 14   Issue: 19
Pp: 2129-2142
Andrea Carotti, Maura Marinozzi, Chiara Custodi, Bruno Cerra, Roberto Pellicciari, Antimo Gioiello and Antonio Macchiarulo
DOI: 10.2174/1568026614666141112094058

Recent Advances in Botulinum Neurotoxin Inhibitor Development

Volume: 14   Issue: 18
Pp: 2044-2061
Erkan Kiris, James C. Burnett, Christopher D. Kane and Sina Bavari
DOI: 10.2174/1568026614666141022093350

A Review on PARP1 Inhibitors: Pharmacophore Modeling, Virtual and Biological Screening Studies to Identify Novel PARP1 Inhibitors

Volume: 14   Issue: 17
Pp: 2020-2030
Sardar Shamshair Singh, Jagarlapudi A.R.P. Sarma, Lakshmi Narasu, Raveendra Dayam, Shili Xu and Nouri Neamati
DOI: 10.2174/1568026614666140929152123

Recent Advances in Computer-Aided Drug Design as Applied to Anti-Influenza Drug Discovery

Volume: 14   Issue: 16
Pp: 1875-1889
Prema L. Mallipeddi, Gyanendra Kumar, Stephen W. White and Thomas R. Webb
DOI: 10.2174/1568026614666140929153812

Exploring Prodrug Approaches for Albitiazolium and its Analogues

Volume: 14   Issue: 14
Pp: 1653-1667
Suzanne Peyrottes, Sergio Caldarelli, Sharon Wein, Christian Perigaud and Henri Vial
DOI: 10.2174/1568026614666140808121746

Tuning hERG Out: Antitarget QSAR Models for Drug Development

Volume: 14   Issue: 11
Pp: 1399-1415
Rodolpho C. Braga, Vinicius M. Alves, Meryck F.B. Silva, Eugene Muratov, Denis Fourches, Alexander Tropsha and Carolina H. Andrade
DOI: 10.2174/1568026614666140506124442

PEGylated Polyester-Based Nanoncologicals

Volume: 14   Issue: 9
Pp: 1097-1114
Claudia Conte, Ivana d’Angelo, Agnese Miro, Francesca Ungaro and Fabiana Quaglia
DOI: 10.2174/1568026614666140329224243

Indole Alkaloids and Semisynthetic Indole Derivatives as Multifunctional Scaffolds Aiming the Inhibition of Enzymes Related to Neurodegenerative Diseases – A Focus on Psychotria L. Genus

Volume: 14   Issue: 8
Pp: 1056-1075
Luiz Carlos Klein-Junior, Carolina dos Santos Passos, Aline Pereira Moraes, Vinicius Galvao Wakui, Eduardo Luis Konrath, Alessandra Nurisso, Pierre-Alain Carrupt, Cecilia Maria Alves de Oliveira, Lucilia Kato and Amelia Teresinha Henriques
DOI: 10.2174/1568026614666140324142409

Decarboxylative Fluorination Strategies for Accessing Medicinally- Relevant Products

Volume: 14   Issue: 7
Pp: 966-978
Yupu Qiao, Lingui Zhu, Brett R. Ambler and Ryan A. Altman
DOI: 10.2174/1568026614666140202210850

Mechanisms of Fibrinogen Adsorption at Solid Substrates

Volume: 14   Issue: 6
Pp: 702-729
Zbigniew Adamczyk, Anna Bratek-Skicki, Paulina Zeliszewska and Monika Wasilewska
DOI: 10.2174/1568026614666140118215158

Assembled Core-Shell Nanostructures of Gold Nanoparticles with Biocompatible Polymers Toward Biology

Volume: 14   Issue: 5
Pp: 595-616
Dongxiang Li, Qianru Li, Xiongwen Hao, Yaojun Zhang, Zhupeng Zhang and Chunfang Li
DOI: 10.2174/1568026614666140118204000

Progress in Developing Amphiphilic Cyclodextrin-Based Nanodevices for Drug Delivery

Volume: 14   Issue: 4
Pp: 526-541
Josias B.G. Yameogo, Annabelle Geze, Luc Choisnard, Jean-Luc Putaux, Rasmane Semde and Denis Wouessidjewe
DOI: 10.2174/1568026613666131219125135

Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry open access plus

Volume: 14   Issue: 2
Pp: 274-289
Sonny Larsson and Nina Ronsted
DOI: 10.2174/1568026613666131216110417

Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review open Access plus

Volume: 14   Issue: 1
Pp: 152-175
Lissa S. Tsutsumi, Yaw B. Owusu, Julian G. Hurdle and Dianqing Sun
DOI: 10.2174/1568026613666131113154753