Current Topics in Medicinal Chemistry


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX

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Most Cited Article

Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years

Volume:18   Issue:2
Pp: 124-148
Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*
DOI: 10.2174/1568026618666180329115523

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer open access plus

Volume:18   Issue:6
Pp: 494-504
Nicholas S. Akins, Tanner C. Nielson and Hoang V. Le*
DOI: 10.2174/1568026618666180523111351

Bis-coumarin Derivatives and Their Biological Activities

Volume:18   Issue:2
Pp: 101-113
Qing-Cheng Ren, Chuan Gao, Zhi Xu, Lian-Shun Feng, Ming-Liang Liu*, Xiang Wu* and Feng Zhao*
DOI: 10.2174/1568026618666180221114515

Recent Development of Small Molecule Glutaminase Inhibitors

Volume:18   Issue:6
Pp: 432-443
Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang
DOI: 10.2174/1568026618666180525100830

Applications of Machine Learning Methods in Drug Toxicity Prediction

Volume:18   Issue:12
Pp: 987-997
Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao and Hongsheng Liu*
DOI: 10.2174/1568026618666180727152557

Target Enzyme in Alzheimer’s Disease: Acetylcholinesterase Inhibitors

Volume:19   Issue:4
Pp: 264-275
Mridula Saxena* and Ragini Dubey
DOI: 10.2174/1568026619666190128125912

Advancements in Docking and Molecular Dynamics Simulations Towards Ligand-receptor Interactions and Structure-function Relationships

Volume:18   Issue:20
Pp: 1755-1768
Ahmad Abu Turab Naqvi, Taj Mohammad, Gulam Mustafa Hasan and Md. Imtaiyaz Hassan*
DOI: 10.2174/1568026618666181025114157

Perspective in Medicinal Chemistry promotion: free to download

Volume:18   Issue:23
Pp: 2000-2001
Dorina Lauritano
DOI: 10.2174/156802661823190110112258

New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation

Volume:18   Issue:1
Pp: 75-87
Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric
DOI: 10.2174/1568026618666180206101814

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

Volume:19   Issue:19
Pp: 1694-1711
Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi and Maria L. Bolognesi*
DOI: 10.2174/1568026619666190619115735

Structure-Based Drug Design Strategies and Challenges

Volume:18   Issue:12
Pp: 998-1006
Xin Wang, Ke Song, Li Li and Lijiang Chen*
DOI: 10.2174/1568026618666180813152921

An Update on MDMX and Dual MDM2/X Inhibitors

Volume:18   Issue:8
Pp: 647-660
Margarida Espadinha, Valentina Barcherini, Elizabeth A. Lopes and Maria M.M. Santos*
DOI: 10.2174/1568026618666180604080119

Structure-Based Virtual Screening for the Identification of High Affinity Compounds as Potent VEGFR2 Inhibitors for the Treatment of Renal Cell Carcinoma

Volume:18   Issue:25
Pp: 2174-2185
Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*
DOI: 10.2174/1568026619666181130142237

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery promotion: free to download

Volume:18   Issue:16
Pp: 1354-1356
Pingyuan Wang and Jia Zhou*
DOI: 10.2174/1568026618666181010101922

Epigenetic Targets and their Inhibitors in Cancer Therapy

Volume:18   Issue:28
Pp: 2395-2419
Le Zhao, Yong-Tao Duan, Ping Lu, Zhi-Juan Zhang, Xiao-Ke Zheng, Jun-Lei Wang* and Wei-Sheng Feng*
DOI: 10.2174/1568026619666181224095449

Recent Development of Coumarin Derivatives as Potential Antiplasmodial and Antimalarial Agents

Volume:18   Issue:2
Pp: 114-123
Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*
DOI: 10.2174/1568026618666171215101158

Small-Molecule Immuno-Oncology Therapy: Advances, Challenges and New Directions promotion: free to download

Volume:19   Issue:3
Pp: 180-185
Shulun Chen, Zilan Song and Ao Zhang*
DOI: 10.2174/1568026619666190308131805

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

Volume:19   Issue:5
Pp: 337-355
Anil Kumar Saxena* and Anamika Singh
DOI: 10.2174/1568026619666190219105722

Biological Activities of Artemisinin Derivatives Beyond Malaria

Volume:19   Issue:3
Pp: 205-222
Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen
DOI: 10.2174/1568026619666190122144217

Structure-based Virtual Screening for the Identification of High-affinity Small Molecule Towards STAT3 for the Clinical Treatment of Osteosarcoma

Volume:18   Issue:29
Pp: 2511-2526
Ravina Khandelwal, Aashish Pratap Singh Chauhan, Swarnima Bilawat, Aishwarya Gandhe, Tajamul Hussain, Elizabeth Anne Hood, Anuraj Nayarisseri* and Sanjeev Kumar Singh*
DOI: 10.2174/1568026618666181115092001

Depression Assessment in Clinical Trials and Pre-clinical Tests: A Critical Review

Volume:18   Issue:19
Pp: 1677-1703
Miguel F. Ferreira, Lígia Castanheira, Ana M. Sebastião and Diogo Telles-Correia*
DOI: 10.2174/1568026618666181115095920