Central Nervous System Agents in Medicinal Chemistry

Conversion of Benzimidazoles, Imidazothiazoles and Imidazoles into more Potent Central Nervous System Acting Drugs open access plus

Volume: 20   Issue: 1
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Saganuwan A. Saganuwan*
DOI: 10.2174/1871524919666190621160323

The Computational Analysis Conducted on miRNA Target Sites in Association with SNPs at 3’UTR of ADHD-implicated Genes open access plus

Volume: 20   Issue: 1
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Adel Abdi, Mina Zafarpiran and Zeinab S. Farsani*
DOI: 10.2174/1871524919666191014104843

An Assessment of the Effects of Azodicarbonamide-containing Diet on Neurobehaviour, Brain Antioxidant Status and Membrane Lipid Peroxidation Status in Rats open access plus

Volume: 20   Issue: 1
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Anthony T. Olofinnade, Adegboyega Adeyeba, Adejoke Y. Onaolapo and Olakunle J. Onaolapo*
DOI: 10.2174/1871524919666191104154009

Screening of Some Novel 4, 5 Disubstituted 1, 2, 4-Triazole-3-thiones for Anticonvulsant Activity

Volume: 20   Issue: 1
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Krishan K. Verma*, Umesh K. Singh and Jainendra Jain
DOI: 10.2174/1871524919666191209103003

Electronegativity in Substituted-4(H)-quinazolinones Causes Anxiolysis without a Sedative-hypnotic Adverse Reaction in Female Wistar Rats

Volume: 20   Issue: 1
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Shweta Mishra, Debashree Das, Adarsh Sahu, Ekta Verma, Shailendra Patil, Ram Kishore Agarwal and Asmita Gajbhiye*
DOI: 10.2174/1871524920666191220112545

An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice

Volume: 20   Issue: 1
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Anthony T. Olofinnade, Tolulope M. Onaolapo, Samad Oladimeji, Adetunji M. Fatoki, Covenant I. Balogun, Adejoke Y. Onaolapo* and Olakunle J. Onaolapo
DOI: 10.2174/1871524920666200120142508

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Majid Asadi-Shekaari
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G. Aliev
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A link Between Brain Insulin Resistance and Cognitive Dysfunctions: Targeting Ca2+/cAMP Signalling

Volume: 20   Issue:
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Leandro Bueno Bergantin*
DOI: 10.2174/1871524920666200129121232

Potential Mechanisms Involved in the Anticonvulsant Effect of Methanol Extract of Pyrenancantha Staudtii in Mice

Volume: 20   Issue:
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Wakeel O. K*, Awosan, B. O, Kolawole O. T, Ayankunle A. A, Onaolapo O. J and Adeyeba O. A
DOI: 10.2174/1871524920666200211113633

Theoretical Study of Monoamine Oxidase B Inhibitors as Drug Candidates for Treatment of Parkinson’s Disease

Volume: 20   Issue:
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Lucilene R. Souza, Leide C. S. Picanço, Maiara F. B. Brito, Marcos R. S. Almeida, Bianca L. B. Marino, Kessia P. A. Sousa, Jaderson V. Ferreira, Cleydson B. S. Rodrigues, Guilherme M. Silva, Carlos H. T. P. Silva, Carlton A. Taft and Lorane I. S. Hage-Melim*
DOI: 10.2174/1871524920666200217110211

Behavioral Evaluation of the Effects of Aqueous and Ethanol Extracts of Suaeda vermiculata Forssk on Rats

Volume: 20   Issue:
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Hamdoon A. Mohammed*
DOI: 10.2174/1871524920666200319142536

α-Substituted Lactams and Acetamides: Ion Channel Modulators that Show Promise in Treating Drug-resistant Epilepsy

Volume: 20   Issue:
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Arcadius V. Krivoshein*
DOI: 10.2174/1871524920666200510005458

Drug Repositioning: Antimalarial Activities of GABA Analogs in Mice Infected with Plasmodium berghei

Volume: 20   Issue:
Pp: 1-12
Akeem Ayankunle*, Olayemi Wakeel, Oyetunji Kolawole, Adesola Oyekale, Olusola Ojurongbe and Oluwaseyi Adeyeba
DOI: 10.2174/1871524920666200604151907

Anti-nociceptive Effect of Euphorbia hirta Leaf Extract: Involvement of Adenosine, Cholinergic, and Opioid Receptors

Volume: 20   Issue:
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T.J Olatoyan-Layonu, O. K Wakeel*, A.I Abe, Olusola Ojurongbe and O.A Adeyeba
DOI: 10.2174/1871524920666200705221956

Understanding the Pathogenesis Involved in Parkinson’s Disease and Potential Therapeutic Treatment Strategies

Volume: 20   Issue:
Pp: 1-14
Meenakshi Dhanawat, Dinesh Kumar Mehta, Sumeet Gupta and Rina Das*
DOI: 10.2174/1871524920666200705222842

Chemistry and Effects of Brainstem Acting Drugs

Volume: 19   Issue: 3
Pp: 180-186
Saganuwan Alhaji Saganuwan*
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Chirality of Central Nervous System (CNS) Acting Drugs: A Formidable Therapeutic Hurdle Against CNS Diseases

Volume: 19   Issue: 3
Pp: 171-179
Saganuwan Alhaji Saganuwan*
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The Role of Melanin to Dissociate Oxygen from Water to Treat Retinopathy of Prematurity open access plus

Volume: 19   Issue: 3
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Arturo S. Herrera, María del Carmen A. Esparza, Paola E.S. Arias, Ghulam M. Ashraf, Osama F. Mosa, Vladimir P. Fisenko, Susanna S. Sologova, Samira A. Dostdar, Alexander V. Sokolov, Elena V. Bovina, Vladimir N. Chubarev, Vadim V. Tarasov, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
DOI: 10.2174/1871524919666190702164206

Noradrenergic Regulation of Hippocampus-Dependent Memory open access plus

Volume: 19   Issue: 3
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Peter V. Nguyen and Steven A. Connor*
DOI: 10.2174/1871524919666190719163632

Design, Synthesis and Biological Activity of Some 4, 5-Disubstituted-2, 4- Dihydro-3H-1, 2, 4- Triazole-3-Thione Derivatives open access plus

Volume: 19   Issue: 3
Pp: 197-205
Krishan Kumar Verma*, Umesh Kumar Singh and Jainendra Jain
DOI: 10.2174/1871524919666190722144424

Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer’s disease open access plus

Volume: 19   Issue: 3
Pp: 154-170
Anurag K. Singh, Santosh K. Singh, Manmath K. Nandi, Gaurav Mishra, Anand Maurya, Arati Rai, Gopal K. Rai, Rajendra Awasthi*, Bhupesh Sharma and Giriraj T. Kulkarni
DOI: 10.2174/1871524919666190820160053

A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors open access plus

Volume: 19   Issue: 3
Pp: 206-214
Chiara Cioni, Maristella Tassi, Giuseppe Marotta, Claudia Mugnaini, Federico Corelli* and Pasquale Annunziata*
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Volume: 19   Issue: 3
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Federico Sesti
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Acrylamide Induced Toxicity and the Propensity of Phytochemicals in Amelioration: A Review

Volume: 19   Issue: 2
Pp: 100-113
Shinomol George Kunnel*, Sunitha Subramanya, Pankaj Satapathy, Ishtapran Sahoo and Farhan Zameer*
DOI: 10.2174/1871524919666190207160236

Glacial Acetic Acid Catalyzed Synthesis, Physicochemical and Biological Evaluation of Benzodiazepines as Potent CNS Agents

Volume: 19   Issue: 2
Pp: 146-151
Vipin Kumar, Shweta Verma* and Sushil Kumar
DOI: 10.2174/1871524919666190227234238

Natural Compounds and Drug Discovery: Can Cnidarian Venom Play a Role?

Volume: 19   Issue: 2
Pp: 114-118
Gian Luigi Mariottini* and Irwin Darren Grice
DOI: 10.2174/1871524919666190227234834

Pharmacological Approach of Pistacia Vera Fruit to Assess Learning and Memory Potential in Chemically-Induced Memory Impairment in Mice

Volume: 19   Issue: 2
Pp: 125-132
Satyam Singh, Dharamveer and Mayank Kulshreshtha*
DOI: 10.2174/1871524919666190304122927

Aging Affects Nicotinic Acetylcholine Receptors in Brain open access plus

Volume: 19   Issue: 2
Pp: 119-124
Yuri N. Utkin*
DOI: 10.2174/1871524919666190320102834

Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review open access plus

Volume: 19   Issue: 2
Pp: 75-99
Nayana Keyla Seabra de Oliveira*, Marcos Rafael Silva Almeida, Franco Márcio Maciel Pontes, Mariana Pegrucci Barcelos, Carlos Henrique Tomich de Paula da Silva, Joaquín María Campos Rosa, Rodrigo Alves Soares Cruz and Lorane Izabel da Silva Hage-Melim*
DOI: 10.2174/1871524919666190502105855

Evaluation of Selected Natural Compounds as Dual Inhibitors of Catechol-O-Methyltransferase and Monoamine Oxidase open access plus

Volume: 19   Issue: 2
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Idalet Engelbrecht, Jacobus P. Petzer and Anél Petzer*
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Volume: 19   Issue: 2
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Sadayuki Hashioka
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Computational Study on the Role of γ-Synuclein in Inhibiting the α-Synuclein Aggregation

Volume: 19   Issue: 1
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Airy Sanjeev and Venkata S.K. Mattaparthi*
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A Novel Non-invasive Effective Method for Potential Treatment of Degenerative Disc Disease: A Hypothesis

Volume: 19   Issue: 1
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Siva G. Somasundaram, Cristian Muresanu, Pamela Schield, Alfiya Makhmutovа, Elena V. Bovina, Vladimir P. Fisenko, Nusrat F. Hasanov and Gjumrakch Aliev*
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Cholinesterase Inhibitory Activities of Selected Halogenated Thiophene Chalcones

Volume: 19   Issue: 1
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Della G.T. Parambi, Fakhrya Aljoufi, Vikneswaran Murugaiyah, Githa E. Mathew, Sanal Dev, Balasubramanain Lakshminarayanan, Omnia M. Hendawy and Bijo Mathew*
DOI: 10.2174/1871524918666181119114016

Design, Synthesis, Anticonvulsant Activity, Preclinical Study and Pharmacokinetic Performance of N-{[3-(4-chlorophenyl)-4-oxo-3, 4-dihydroquinazolin- 2-yl] methyl}, 2-[(2-isopropyl-5-methyl) 1-cyclo Hexylidene] Hydrazinecarboxamide

Volume: 19   Issue: 1
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Meena K. Yadav and Laxmi Tripathi *
DOI: 10.2174/1871524919666181122124012

Development and Characterization of Nasal Delivery of Selegiline Hydrochloride Loaded Nanolipid Carriers for the Management of Parkinson’s Disease

Volume: 19   Issue: 1
Pp: 46-56
Neeraj Mishra*, Sawarni Sharma, Rahul Deshmukh, Anoop Kumar and Ruchika Sharma
DOI: 10.2174/1871524919666181126124846

Bacopa monnieri Supplements Offset Paraquat-Induced Behavioral Phenotype and Brain Oxidative Pathways in Mice

Volume: 19   Issue: 1
Pp: 57-66
Gokul Krishna*, Ravikumar Hosamani and Muralidhara
DOI: 10.2174/1871524919666190115125900

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Volume: 19   Issue: 1
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Da-Yong Lu*, Peng-Peng Zhu, Hong-Ying Wu, Bin Xu and Ting-Ren Lu
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Unraveling the Structural Requirements of Chalcone Chemistry Towards Monoamine Oxidase Inhibition promotion: free to download

Volume: 19   Issue: 1
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Bijo Mathew
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Yuri N. Utkin
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Gjumrakch Aliev
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Neuropharmacological Profile of Gamma-Decanolactone on Chemically-induced Seizure in Mice

Volume: 18   Issue: 3
Pp: 222-227
Pricila Pfluger, Vanessa Rodrigues Coelho, Gabriela Gregory Regner, Lucas Lima da Silva, Karina Martinez, Alan Fonseca, Cassiana Macagnan Viau and Patricia Pereira*
DOI: 10.2174/1871524918666180611103802

Malaria, Antimalaria Drugs, Drug/Parasite Interactions, and the Brain: A Review of Impacts on Behaviour, Neurochemistry and Structure

Volume: 18   Issue: 3
Pp: 173-192
Onaolapo Adejoke Yetunde, Onaolapo Olakunle James* and Adeyeba Oluwaseyi Adegboyega
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Brain and Quantum Dots: Benefits of Nanotechnology for Healthy and Diseased Brain open access plus

Volume: 18   Issue: 3
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Yuri N. Utkin*
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Human Suicide Risk and Treatment Study

Volume: 18   Issue: 3
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Da-Yong Lu*, Peng-Peng Zhu, Hong-Ying Wu, Nagendra Sastry Yarla, Bin Xu and Ting-Ren Lu
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Classification (Agonist/Antagonist) and Regression “Structure-Activity” Models of Drug Interaction with 5-HT6

Volume: 18   Issue: 3
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Oleg A. Raevsky, Veniamin Y. Grigorev, Alexander V. Yarkov, Daniel E. Polianczyk, Vadim V. Tarasov, Elena V. Bovina, Elena N. Bryzhakina, John C. Dearden, Marco Avila-Rodriguez and Gjumrakch Aliev*
DOI: 10.2174/1871524918666180827100437

Recent Finding in Repair of the Peripheral Nerve Lesions Using Pharmacological Agents: Common Methods for Evaluating the Repair Process

Volume: 18   Issue: 3
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Dheyauldeen Shabeeb, Masoud Najafi, Mansor Keshavarz, Ahmed Eleojo Musa, Gholamreza Hassanzadeh, Mohammed Reza Hadian and Alireza Shirazi*
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Dora Zelena
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ISATIN: New Hope Against Convulsion

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Rameshwar S. Cheke, Sandip D. Firke*, Ravindra R. Patil and Sanjay B. Bari
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Evaluation of In Silico Anti-parkinson Potential of β-asarone

Volume: 18   Issue: 2
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Meenakshi Gupta, Kamal Kant, Ruchika Sharma and Anoop Kumar*
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Nitrocatechol Derivatives of Chalcone as Inhibitors of Monoamine Oxidase and Catechol-O-Methyltransferase

Volume: 18   Issue: 2
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Idalet Engelbrecht, Jacobus P. Petzer and Anel Petzer*
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Synthesis and Evaluation of 2-benzylidene-1-tetralone Derivatives for Monoamine Oxidase Inhibitory Activity

Volume: 18   Issue: 2
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Klaudia T. Amakali, Lesetja J. Legoabe*, Anel Petzer and Jacobus P. Petzer
DOI: 10.2174/1871524918666180501121638

In-Silico Screening of Ligand Based Pharmacophore, Database Mining and Molecular Docking on 2, 5-Diaminopyrimidines Azapurines as Potential Inhibitors of Glycogen Synthase Kinase-3β

Volume: 18   Issue: 2
Pp: 150-158
Pooja Mishra, Seema Kesar*, Sarvesh K. Paliwal, Monika Chauhan and Kirtika Madan
DOI: 10.2174/1871524918666180530074116

Recent Findings in Melatonin Research and Their Relevance to the CNS

Volume: 18   Issue: 2
Pp: 102-114
Rudiger Hardeland*
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Ramon Cacabelos
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Role of the α7 Nicotinic Acetylcholine Receptor and RIC-3 in the Cholinergic Anti-inflammatory Pathway

Volume: 17   Issue: 2
Pp: 90-99
Treinin M, Papke RL, Nizri E, Ben-David Y, Mizrachi T and Brenner T*
DOI: 10.2174/1871524916666160829114533

Old Weapons for New Wars: Bioactive Molecules From Cnidarian Internal Defense Systems

Volume: 16   Issue: 3
Pp: 183-196
Trapani M. Rosa, Parisi M. Giovanna, Maisano Maria, Mauceri Angela and Cammarata Matteo
DOI: 10.2174/1871524915666150710120650

Cnidarian Neurotoxic Peptides Affecting Central Nervous System Targets

Volume: 16   Issue: 3
Pp: 173-182
Fernando Lazcano-Pérez, Ulises Hernández-Guzmán, Judith Sánchez-Rodríguez and Roberto Arreguín-Espinosa
DOI: 10.2174/1871524915666150722120915

Indolealkylamines from Toad Vertebrates and Sea Invertebrates - Their Identification and Potential Activities on the Central Nervous System

Volume: 16   Issue: 3
Pp: 197-207
Abu Hasanat Md. Zulfiker, Gian Luigi Mariottini, Ji Qi, I. Darren Grice and Ming Q. Wei
DOI: 10.2174/1871524915666150724100245

Preliminary Study on Nematocyst Types and Venom Isolation of Cassiopea andromeda Forskål, 1775 (Scyphozoa, Cnidaria) from Turkey

Volume: 16   Issue: 3
Pp: 208-212
Nurçin Gülşahin
DOI: 10.2174/1871524915666150826092321

Analgesic and CNS Depressant Activities of Sea Anemone Heteractis aurora Nematocyst Toxin

Volume: 16   Issue: 3
Pp: 167-172
Sengapillai Thangaraj, Subramanian Bragadeeswaran, Natarajah Srikumaran and Anbukkarasu Suguna
DOI: 10.2174/1871524916666160129101049

The Suicidal Risks and Treatments, Seek Medications from Multi-disciplinary

Volume: 16   Issue: 3
Pp: 231-239
Da-Yong Lu, Peng-Peng Zhu, Ting-Ren Lu and Jin-Yu Che
DOI: 10.2174/1871524916666160210142734

Topiramate: A Novel Therapeutic Candidate for Diabetes and Aggression? Positron Emission Tomography (PET) Findings

Volume: 16   Issue: 3
Pp: 227-230
Burak Yulug, Lütfü Hanoglu, Ahmet Mithat Tavli, Tansel Cakir, Oktay Olmuscelik, Burak Pakoz and Gülşen Ünlü
DOI: 10.2174/1871524916666160301102055

Analgesic Effects Mediated by Muscarinic Receptors: Mechanisms and Pharmacological Approaches

Volume: 16   Issue: 3
Pp: 218-226
Federica De Angelis and Ada Maria Tata
DOI: 10.2174/1871524916666160302103033

Schiff Bases of Benzothiazol-2-ylamine and Thiazolo[5,4-b] pyridin-2-ylamine as Anticonvulsants: Synthesis, Characterization and Toxicity Profiling* open access plus

Volume: 16   Issue: 3
Pp: 240-248
Rashmi Shukla, Ajeet P. Singh, Pankaj K. Sonar, Mudita Mishra and Shailendra K. Saraf*
DOI: 10.2174/1871524916666160428110728

Toxicity of Mediterranean Scyphomedusae: An Overview

Volume: 16   Issue: 3
Pp: 213-217
Paola Del Negro, Ciriaco Saul, Cataletto Bruno, Delogu G. Maria and Kokelj Franco
DOI: 10.2174/1871524916666160505114153

Molecular Docking Studies of Some Novel Antidepressant 5-Substituted Phenyl-3-(Thiophen-2-yl)-4, 5-Dihydro-1h-Pyrazole-1-Carboxamides Against Monoamine Oxidase Isoforms

Volume: 16   Issue: 2
Pp: 75-80
Bijo Mathew, Jerad Suresh, Sockalingam Anbazhagan and Sanal Dev
DOI: 10.2174/1871524915666150216123707

Pharmacophore Modeling, 3D-QSAR and Molecular Docking of Furanochalcones as Inhibitors of Monoamine Oxidase-B

Volume: 16   Issue: 2
Pp: 105-111
Bijo Mathew, Sanal Dev, Jerad Suresh, Githa E. Mathew, Baskar Lakshmanan, Abitha Haridas, Fajeelath Fathima and Girish K. Krishnan
DOI: 10.2174/1871524915666150319122540

Synthetic and Natural Monoamine Oxidase Inhibitors as Potential Lead Compounds for Effective Therapeutics

Volume: 16   Issue: 2
Pp: 81-97
Ashish Pathak, Amit K. Srivastava, Pradeep K. Singour and Panchanan Gouda
DOI: 10.2174/1871524915666150624120516

Synthesis and Anticonvulsant Effect of Novel Thiazolidinedione Containing Benzene-sulfonylurea and Sulfonylthiourea Derivatives

Volume: 16   Issue: 2
Pp: 152-157
Alok S. Thakur, Ravitas Deshmukh, Arvind K. Jha and P. Sudhir Kumar
DOI: 10.2174/1871524915666150824154136

Leflunomide, a Reversible Monoamine Oxidase Inhibitor

Volume: 16   Issue: 2
Pp: 112-119
Jacobus P. Petzer and Anél Petzer
DOI: 10.2174/1871524915666150824154329

Opening New Scenarios for Human MAO Inhibitors open access plus

Volume: 16   Issue: 2
Pp: 98-104
Celeste De Monte, Melissa D'Ascenzio, Paolo Guglielmi, Veronica Mancini and Simone Carradori
DOI: 10.2174/1871524915666150831141705

Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review

Volume: 16   Issue: 2
Pp: 120-136
Bijo Mathew, Abitha Haridas, Jerad Suresh, Githa E. Mathew, Gülberk Uçar and Venkatesan Jayaprakash
DOI: 10.2174/1871524915666151002124443

Targeting Dopaminergic System for Treating Nicotine Dependence

Volume: 16   Issue: 2
Pp: 137-142
Sawsan Abuhamdah, Ashraf Khalil and Youssef Sari
DOI: 10.2174/1871524916666151104115421

Hansch Analysis of Novel Acetamide Derivatives as Highly Potent and Specific MAO-A Inhibitors

Volume: 16   Issue: 2
Pp: 143-151
Ashish Pathak, Pradeep K. Singour, Amit K. Srivastava, Panchanan Gouda, Sunil Kumar and Bhupendra K. Goutam
DOI: 10.2174/1871524916666151210143347

Thiophene Scaffold as Prospective Central Nervous System Agent: A Review

Volume: 16   Issue: 2
Pp: 158-164
Aakash Deep, Balasubramanian Narasimhan, Swati Aggarwal, Dhirender Kaushik and Arun K. Sharma
DOI: 10.2174/1871524916666160204114424

The Efficacies and Toxicities of Antidepressant Drugs in Clinics, Building the Relationship between Chemo-Genetics and Socio-Environments promotion: free to download

Volume: 16   Issue: 1
Pp: 12-18
Da-Yong Lu, Ting-Ren Lu, Peng-Peng Zhu and Jin-Yu Che
DOI: 10.2174/1871524915666150430131511