Prenylated Flavonoids: Pharmacology and Biotechnology

Title: Prenylated Flavonoids: Pharmacology and Biotechnology

Volume: 12 Issue: 6

Author(s): Bruno Botta, Alberto Vitali, Pilar Menendez, Domenico Misiti and Giuliano Delle Monache

Affiliation:

Keywords: antimicrobial, phytoalexins, isoprenoid chemistry, oxidations, biosynthesis, dorstenia, papyriflavonol a, bioassay guided fractionation

Abstract: Within the flavonoid class of natural products the prenylated sub-class is quite rich in structural variety and pharmacological activity. In the last twenty years a huge number of new structures has been reported, mostly from Leguminosae and Moraceae, with few coming from other genera. The presence, in different forms, of the isoprenoid chain can lead to impressive changes in biological activity, mostly attributed to an increased affinity for biological membranes and to an improved interaction with proteins. Molecules, such as xanthohumol and sophoraflavanone G, while being very structurally simple, show numerous pharmacological applications and are ideal candidates for SAR aimed to the discovery of new drugs. Only recently the biogenesis of these compounds has been more extensively studied and much attention has been focused on the enzymes involved in the modification and transfer of the prenyl unit.

Cite this article as:

Botta Bruno, Vitali Alberto, Menendez Pilar, Misiti Domenico and Monache Delle Giuliano, Prenylated Flavonoids: Pharmacology and Biotechnology, Current Medicinal Chemistry 2005; 12 (6) . https://dx.doi.org/10.2174/0929867053202241