Betulinic Acid and Its Derivatives: A Review on their Biological Properties

Title: Betulinic Acid and Its Derivatives: A Review on their Biological Properties

Volume: 12 Issue: 6

Author(s): Perumal Yogeeswari and Dharmarajan Sriram

Affiliation:

Keywords: betulinic acid, anti-hiv derivatives, anti-hiv mechanism, anticancer derivatives, anticancer mechanism, antiinflammatory, antimalarial, biotransformation

Abstract: Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, antiinflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990s to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated.

Cite this article as:

Yogeeswari Perumal and Sriram Dharmarajan, Betulinic Acid and Its Derivatives: A Review on their Biological Properties, Current Medicinal Chemistry 2005; 12 (6) . https://dx.doi.org/10.2174/0929867053202214