Abstract
This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.
Keywords: parallel, combinatorial, gpcr, protease, kinase, nuclear hormone receptor
Current Medicinal Chemistry
Title: Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization
Volume: 12 Issue: 11
Author(s): Stephen J. Shuttleworth, Richard V. Connors, Jiasheng Fu, Jinqian Liu, Mike E. Lizarzaburu, Wei Qiu, Rajiv Sharma, Malgorzata Wanska and Alex J. Zhang
Affiliation:
Keywords: parallel, combinatorial, gpcr, protease, kinase, nuclear hormone receptor
Abstract: This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.
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Cite this article as:
Shuttleworth J. Stephen, Connors V. Richard, Fu Jiasheng, Liu Jinqian, Lizarzaburu E. Mike, Qiu Wei, Sharma Rajiv, Wanska Malgorzata and Zhang J. Alex, Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization, Current Medicinal Chemistry 2005; 12 (11) . https://dx.doi.org/10.2174/0929867054020936
DOI https://dx.doi.org/10.2174/0929867054020936 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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