Abstract
The intestinal epithelium has emerged as one of the links between the innate and adaptive immune systems. Novel roles have been elucidated for its participation in antigen uptake and presentation, costimulatory signaling, and intestinal homeostasis. Its concomitant interaction with immune cells and commensal flora demonstrates the epitheliums multifaceted responsibility in protecting against intestinal pathology while maintaining immune competence. Its functional capacity is now more clearly defined in disease states such as celiac disease, Crohns disease, and ulcerative colitis and in maintaining intestinal integrity through toll-like receptor signaling pathways.
Keywords: intestinal epithelial cells, intestinal trefoil factor, dextran sulfate sodium, decay-accelerating factor, antimicrobial peptides, cell surface molecules, chemokines and cytokines
Current Molecular Medicine
Title: Mucosal Epithelium in Health and Disease
Volume: 5 Issue: 6
Author(s): Prashant P. Ponda and Lloyd Mayer
Affiliation:
Keywords: intestinal epithelial cells, intestinal trefoil factor, dextran sulfate sodium, decay-accelerating factor, antimicrobial peptides, cell surface molecules, chemokines and cytokines
Abstract: The intestinal epithelium has emerged as one of the links between the innate and adaptive immune systems. Novel roles have been elucidated for its participation in antigen uptake and presentation, costimulatory signaling, and intestinal homeostasis. Its concomitant interaction with immune cells and commensal flora demonstrates the epitheliums multifaceted responsibility in protecting against intestinal pathology while maintaining immune competence. Its functional capacity is now more clearly defined in disease states such as celiac disease, Crohns disease, and ulcerative colitis and in maintaining intestinal integrity through toll-like receptor signaling pathways.
Export Options
About this article
Cite this article as:
Ponda P. Prashant and Mayer Lloyd, Mucosal Epithelium in Health and Disease, Current Molecular Medicine 2005; 5 (6) . https://dx.doi.org/10.2174/1566524054863933
DOI https://dx.doi.org/10.2174/1566524054863933 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Transcription Factors and Regulators Pathway-focused Genes Expression
Analysis in Patients with Different Forms of Thyroid Pathology
Current Pharmaceutical Biotechnology Early Functional and Structural Microvascular Changes in Hypertension Related to Aging
Current Hypertension Reviews Animal Models in Neurology: Drawbacks and Opportunities
Current Pharmaceutical Design Chlorella vulgaris Induces Apoptosis of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells
Medicinal Chemistry Non-Hormonal Replacement Therapy Regimens: Do they have an Effect on Cardiovascular Risk?
Current Vascular Pharmacology Place of Nanofiltration for Assuring Viral Safety of Biologicals
Current Nanoscience Designing Cytokine Variants by Phage-Display
Combinatorial Chemistry & High Throughput Screening Pulmonary Defence Mechanisms
Current Respiratory Medicine Reviews Metformin one in a Million Efficient Medicines for Rheumatoid Arthritis Complications: Inflammation, Osteoblastogenesis, Cardiovascular Disease, Malignancies
Current Rheumatology Reviews Vaccine Therapy for P. acnes-Associated Diseases
Infectious Disorders - Drug Targets Green Tea (Camellia sinensis) Protects Against Arsenic Neurotoxicity via Antioxidative Mechanism and Activation of Superoxide Dismutase Activity
Central Nervous System Agents in Medicinal Chemistry A Retrospective Study on <i>Gloriosa superba</i> and Its Main Active Constituents
The Natural Products Journal Heparin Derivatives as Angiogenesis Inhibitors
Current Pharmaceutical Design Current Status and Future Prospects of Small–molecule Protein–protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)
Current Topics in Medicinal Chemistry Synthesis and Immunomodulation of Human Lymphocyte Proliferation and Cytokine (Interferon-γ) Production of Four Novel Leflunomide Analogues
Medicinal Chemistry Possible Roles of Microglial Cells for Neurotoxicity in Clinical Neurodegenerative Diseases and Experimental Animal Models
Inflammation & Allergy - Drug Targets (Discontinued) Hematological Malignancies and Pregnancy. A Brief Review
Reviews on Recent Clinical Trials Structure-Based Design in the GPCR Target Space
Current Medicinal Chemistry Quantitative Analysis of Salicylic Acid and its Derivatives in Primulae radix by High Performance Liquid Chromatography-Diode Array Detection- Electrospray Ionization Mass Spectrometry (HPLC-DAD-ESI-MS) and Simultaneous Determination of Total Polyphenol Content (TPC)
Current Analytical Chemistry Biologic Agents in the Treatment of Rheumatoid Arthritis
Current Pharmaceutical Biotechnology