Abstract
This review deals with the applications of the Favorskii rearrangement in synthetic Organic Chemistry, paying especial attention to the literature appeared after 1980. The mentioned rearrangement plays a key role in many total synthesis due to the fact that important modifications in the structure of the substrate occur during the process. Skeletal rearrangements in acyclic systems, leading to highly branched carboxylic acids and its derivatives, as well as structural changes in cyclic substrates, which result in ring contraction processes, are described. Some examples of Favorskii rearrangements in biosynthetic pathways are also presented.
Keywords: skeletal rearrangement, Deprotonation, cyclopropanone, organic synthesis, Imine Derivatives, Favorskii-Like Processes, Homo-Favorskii Reactions
Current Organic Chemistry
Title: The Favorskii Rearrangement: Synthetic Applications
Volume: 9 Issue: 17
Author(s): D. Guijarro and M. Yus
Affiliation:
Keywords: skeletal rearrangement, Deprotonation, cyclopropanone, organic synthesis, Imine Derivatives, Favorskii-Like Processes, Homo-Favorskii Reactions
Abstract: This review deals with the applications of the Favorskii rearrangement in synthetic Organic Chemistry, paying especial attention to the literature appeared after 1980. The mentioned rearrangement plays a key role in many total synthesis due to the fact that important modifications in the structure of the substrate occur during the process. Skeletal rearrangements in acyclic systems, leading to highly branched carboxylic acids and its derivatives, as well as structural changes in cyclic substrates, which result in ring contraction processes, are described. Some examples of Favorskii rearrangements in biosynthetic pathways are also presented.
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Cite this article as:
Guijarro D. and Yus M., The Favorskii Rearrangement: Synthetic Applications, Current Organic Chemistry 2005; 9 (17) . https://dx.doi.org/10.2174/138527205774610912
DOI https://dx.doi.org/10.2174/138527205774610912 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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