Abstract
The blood brain barrier, formed by brain capillary endothelial cells, represents the major obstacle for drug entry into the central nervous system. Efforts are ongoing to overcome this barrier without causing permanent damage to brain tissue. The present review attempts to provide key information on cerebral microvessel anatomy, features contributing to barrier function and current approaches in overcoming the blood-brain barrier using cellular and molecular methodologies to transfer drugs to the brain as well as intelligent drug delivery systems.
Keywords: blood-brain barrier, p-glycoprotein, drug delivery systems, nanoparticles, Immuno-liposomes
Current Nanoscience
Title: Drug Delivery Across the Blood-Brain Barrier
Volume: 1 Issue: 3
Author(s): Anika M.S. Hartz, Bjorn Bauer, Carsten H. Baehr, David S. Miller and Gert Fricker
Affiliation:
Keywords: blood-brain barrier, p-glycoprotein, drug delivery systems, nanoparticles, Immuno-liposomes
Abstract: The blood brain barrier, formed by brain capillary endothelial cells, represents the major obstacle for drug entry into the central nervous system. Efforts are ongoing to overcome this barrier without causing permanent damage to brain tissue. The present review attempts to provide key information on cerebral microvessel anatomy, features contributing to barrier function and current approaches in overcoming the blood-brain barrier using cellular and molecular methodologies to transfer drugs to the brain as well as intelligent drug delivery systems.
Export Options
About this article
Cite this article as:
Hartz M.S. Anika, Bauer Bjorn, Baehr H. Carsten, Miller S. David and Fricker Gert, Drug Delivery Across the Blood-Brain Barrier, Current Nanoscience 2005; 1 (3) . https://dx.doi.org/10.2174/157341305774642948
DOI https://dx.doi.org/10.2174/157341305774642948 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Potencial Theranostic Agent for EGF-R Expression Tumors: 177Lu- DOTA-Nimotuzumab
Current Radiopharmaceuticals Brain Delivery of Chemotherapeutics in Brain Cancer
Anti-Cancer Agents in Medicinal Chemistry Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs
Current Drug Metabolism Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets
Current Pharmaceutical Design The Development of Epigenetics and Related Inhibitors for Targeted Drug Design in Cancer Therapy
Current Topics in Medicinal Chemistry Potential Usage of ING Family Members in Cancer Diagnostics and Molecular Therapy
Current Drug Targets A Novel Lily-of-the-Valley Fragrance Contrast Agent for Magnetic Resonance and Fluorescence Imaging of Prostate Cancer Cells
Current Pharmaceutical Biotechnology MMP14 Regulates VEGFR3 Expression on Corneal Epithelial Cells
Protein & Peptide Letters Mitochondria-Targeting Anticancer Metal Complexes
Current Medicinal Chemistry Oligonucleotide Aptamers for Glioma Targeting: An Update
Central Nervous System Agents in Medicinal Chemistry Proteomic Analysis of Mitochondrial Proteins on the Mechanism of Apoptotic Under Amorphophallus konjac Tuber (KONJAC) Extracts in Gas tric Cancer Cell
Current Proteomics Physical and Chemical Stimuli-Responsive Drug Delivery Systems: Targeted Delivery and Main Routes of Administration
Current Pharmaceutical Design Polyethylenimine as a Promising Vector for Targeted siRNA Delivery
Current Clinical Pharmacology The Role of Aryl Hydrocarbon Receptor-Regulated Cytochrome P450 Enzymes in Glioma
Current Pharmaceutical Design The 1,4-Dihydropyridine Nucleus: A Pharmacophoric Template Part 1. Actions at Ion Channels
Mini-Reviews in Medicinal Chemistry Dendritic Cells in Esophageal Adenocarcinoma: The Currently Available Information and Possibilities to use Dendritic Cells for Immunotherapeutic Approaches
Current Pharmaceutical Design Recent Patents and Patent Applications Relating to mTOR Pathway
Recent Patents on DNA & Gene Sequences Mitochondrial and Nuclear Genes of Mitochondrial Components in Cancer
Current Genomics Polyphenols and Neuroprotection against Ischemia and Neurodegeneration
Mini-Reviews in Medicinal Chemistry Patent Selections:
Current Biomarkers (Discontinued)