Current Pharmaceutical Design

Editor-in-Chief

Alessandro Antonelli
(12,288 citations)
Laboratory of Primary Human Cells
University of Pisa
Pisa
(Italy)

Executive Editor

Atta-ur-Rahman, FRS
(32052 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
(UK)
Biography

Nobel Laureate on Editorial Board

Andrew V. Schally
(USA)

Personal Subscription
Become EABM
Become Reviewer
Call for Editor

Open Access Articles

Anti-malarial Drugs are Not Created Equal for SARS-CoV-2 Treatment: A Computational Analysis Evidence open Access plus

Volume: 27   Issue: 10
Pp: 1323-1329
Simone Ronsisvalle, Federica Panarello, Rosaria Di Mauro, Renato Bernardini, Giovanni Li Volti* and Giuseppina Cantarella
DOI:10.2174/1381612826666201210092736

Effects of an Integrative Mind-Body-Medicine Group Program on Breast Cancer Patients During Chemotherapy: An Observational Study open Access plus

Volume: 27   Issue: 8
Pp: 1112-1120
Heidemarie Haller, Kyung-Eun Choi, Silke Lange, Sherko Kümmel, Anna Paul, Holger Cramer, Gustav Dobos and Petra Voiss*
DOI:10.2174/1381612826666201211111122

Improvement in Hypertension Management with Pharmacological and Non- Pharmacological Approaches: Current Perspectives open Access plus

Volume: 27   Issue: 4
Pp: 548-555
Dongsheng Hong* and Wenya Shan
DOI:10.2174/1381612826666200922153045

The Pathogenic Subpopulation of Th17 Cells in Obesity open Access plus

Volume: 27  
Pp: 1-15
Natalia Todosenko, Maria Vulf*, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova*
DOI:10.2174/1381612826666210101154913

Exosome Limitations in the Treatment of Inflammatory Diseases open Access plus

Volume: 27  
Pp: 1-17
Daria Skuratovskaia*, Maria Vulf, Olga Khaziakhmatova, Vladimir Malashchenko, Aleksandra Komar, Egor Shunkin, Natalia Gazatova and Larisa Litvinova
DOI:10.2174/1381612826666201210120444

Treatment of Anderson-Fabry Disease open Access plus

Volume: 26   Issue: 40
Pp: 5089-5099
Irene Simonetta*, Antonino Tuttolomondo, Mario Daidone, Salvatore Miceli and Antonio Pinto
DOI:10.2174/1381612826666200317142412

Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders open Access plus

Volume: 26   Issue: 36
Pp: 4569-4579
Tejashree Waghule, Vamshi Krishna Rapalli, Srividya Gorantla, Ranendra Narayan Saha, Sunil Kumar Dubey, Anu Puri and Gautam Singhvi*
DOI:10.2174/1381612826666200614175236

A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats open Access plus

Volume: 26   Issue: 31
Pp: 3884-3894
Branka Petković*, Srđan Kesić, Slavica Ristić, Željko Pavković, Jelena Podgorac, Gordana Stojadinović and Vesna Pešić
DOI:10.2174/1381612826666200326125821

Radiotheragnostics Paradigm for Radioactive Iodine (Iodide) Management of Differentiated Thyroid Cancer open Access plus

Volume: 26   Issue: 31
Pp: 3812-3827
Einat Slonimsky and Mark Tulchinsky*
DOI:10.2174/1381612826666200605121054

γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster - A Systematic Review and Meta-analysis open Access plus

Volume: 26   Issue: 25
Pp: 3026-3038
Wuttapon Sadaeng, Katalin Márta, Péter Mátrai, Péter Hegyi, Barbara Tóth, Balázs Németh, László M. Czumbel, Thanyaporn Sang-Ngoen, Zoltán Gyöngyi, Gábor Varga*, Péter Révész, István Szanyi, Kázmér Karádi and Gábor Gerber
DOI:10.2174/1381612826666200605120242

Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis open Access plus

Volume: 26   Issue: 25
Pp: 3015-3025
Beáta Kerémi, Katalin Márta, Kornélia Farkas, László M. Czumbel, Barbara Tóth, Zsolt Szakács, Dezső Csupor, József Czimmer, Zoltán Rumbus, Péter Révész, Adrienn Németh, Gábor Gerber, Péter Hegyi and Gábor Varga*
DOI:10.2174/1381612826666200515134450

Artemia species: An Important Tool to Screen General Toxicity Samples open Access plus

Volume: 26   Issue: 24
Pp: 2892-2908
Epole Ntungwe N, Eva M. Domínguez-Martín, Amilcar Roberto, Joana Tavares, Vera M. S. Isca, Paula Pereira, Maria-João Cebola and Patrícia Rijo*
DOI:10.2174/1381612826666200406083035

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review open Access plus

Volume: 26   Issue: 16
Pp: 1917-1928
Tânia C. S. P. Pires , Cristina Caleja , Celestino Santos-Buelga , Lillian Barros* and Isabel C.F.R. Ferreira*
DOI:10.2174/1381612826666200317132507

Cerebrovascular Changes and Neurodegeneration Related to Hyperlipidemia: Characteristics of the Human ApoB-100 Transgenic Mice open Access plus

Volume: 26   Issue: 13
Pp: 1486-1494
Melinda E. Tóth*, Brigitta Dukay , Zsófia Hoyk and Miklós Sántha
DOI:10.2174/1381612826666200218101818

Drug Development for Central Nervous System Diseases Using In vitro Blood-brain Barrier Models and Drug Repositioning open Access plus

Volume: 26   Issue: 13
Pp: 1466-1485
Yoichi Morofuji* and Shinsuke Nakagawa
DOI:10.2174/1381612826666200224112534

Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis open Access plus

Volume: 26   Issue: 13
Pp: 1417-1427
Carolin J. Curtaz, Constanze Schmitt, Kinga G. Blecharz-Lang, Norbert Roewer, Achim Wöckel and Malgorzata Burek*
DOI:10.2174/1381612826666200316151720

A Chronological Review of Potential Disease-Modifying Therapeutic Strategies for Alzheimer's Disease open Access plus

Volume: 26   Issue: 12
Pp: 1286-1299
Miren Ettcheto, Oriol Busquets, Triana Espinosa-Jiménez, Ester Verdaguer , Carme Auladell and Antoni Camins*
DOI:10.2174/1381612826666200211121416

Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder open Access plus

Volume: 26   Issue: 4
Pp: 466-484
Branka Petković*, Srđan Kesić and Vesna Pešić
DOI:10.2174/1381612826666200115094642

Role of microRNA and Long Non-Coding RNA in Hepatocellular Carcinoma open Access plus

Volume: 26   Issue: 4
Pp: 415-428
Meenakshi Gupta, Kumari Chandan and Maryam Sarwat*
DOI:10.2174/1381612826666200115093835

Adrenergic and Cholinergic Uterine Innervation and the Impact on Reproduction in Aged Women open Access plus

Volume: 26   Issue: 3
Pp: 358-362
Ioannis P. Kosmas, Antonio Malvasi, Daniele Vergara, Ospan A. Mynbaev, Radmila Sparic and Andrea Tinelli*
DOI:10.2174/1381612826666200128092256

Burden and Prevention of HPV. Knowledge, Practices and Attitude Assessment Among Pre-Adolescents and their Parents in Italy open Access plus

Volume: 26   Issue: 3
Pp: 326-342
Giancarlo Icardi, Claudio Costantino, Marcello Guido, Antonella Zizza, Vincenzo Restivo, Daniela Amicizia, Federico Tassinari, Maria Francesca Piazza, Chiara Paganino, Alessandra Casuccio, Francesco Vitale, Filippo Ansaldi and Cecilia Trucchi*
DOI:10.2174/1381612826666200114100553

Specificity and Continuity of Schizophrenia and Bipolar Disorder: Relation to Biomarkers open Access plus

Volume: 26   Issue: 2
Pp: 191-200
Yuji Yamada, Madoka Matsumoto, Kazuki Iijima and Tomiki Sumiyoshi*
DOI:10.2174/1381612825666191216153508

RHPN1-AS1 Drives the Progression of Hepatocellular Carcinoma via Regulating miR-596/IGF2BP2 Axis open Access plus

Volume: 25   Issue: 43
Pp: 4630-4640
Hu Fen, Zheng Hongmin, Wei Wei, Yang Chao, Yao Yang, Liu Bei and Sun Zhihua*
DOI:10.2174/1381612825666191105104549

Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro open Access plus

Volume: 25   Issue: 43
Pp: 4606-4612
Yuan-Qi Shi, Pan Fan, Guo-Cui Zhang, Yu-Hao Zhang, Ming-Zhu Li, Fang Wang and Bao-Xin Li*
DOI:10.2174/1381612825666191026170033

Neurological Disorder Drug Discovery from Gene Expression with Tensor Decomposition open Access plus

Volume: 25   Issue: 43
Pp: 4589-4599
Y-h. Taguchi* and Turki Turki
DOI:10.2174/1381612825666191210160906

Nanomedicines to Treat Skin Pathologies with Natural Molecules open Access plus

Volume: 25   Issue: 21
Pp: 2323-2337
Elisabetta Esposito*, Claudio Nastruzzi, Maddalena Sguizzato and Rita Cortesi
DOI:10.2174/1381612825666190709210703

The Role of Autophagy and Death Pathways in Dose-dependent Isoproterenolinduced Cardiotoxicity open Access plus

Volume: 25   Issue: 19
Pp: 2192-2198
Alexandra Gyongyosi, Rita Zilinyi, Andras Czegledi, Agnes Tosaki, Arpad Tosaki and Istvan Lekli*
DOI:10.2174/1381612825666190619145025

Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway open Access plus

Volume: 25   Issue: 16
Pp: 1828-1846
Ana Paunkov, Dionysios V. Chartoumpekis, Panos G. Ziros, Niki Chondrogianni, Thomas W. Kensler and Gerasimos P. Sykiotis*
DOI:10.2174/1381612825666190701165821

Treatment of Glucocorticoid-Induced Osteoporosis with Bisphosphonates Alone, Vitamin D Alone or a Combination Treatment in Eastern Asians: A Meta-Analysis open Access plus

Volume: 25   Issue: 14
Pp: 1653-1662
Junjie Wang and Hongzhuo Li*
DOI:10.2174/1381612825666190619125426

Circulating Factors and Ultrasono-findings are Linked to Previous Atherosclerotic Burden and Recurrent Risk open Access plus

Volume: 25   Issue: 12
Pp: 1424-1429
Kyoung J. Cho, Jihye Kim, Soung H. Jeon and Gyung W. Kim*
DOI:10.2174/1381612825666190620145845

Effects of As2O3 and Resveratrol on the Proliferation and Apoptosis of Colon Cancer Cells and the hERG-mediated Potential Mechanisms open Access plus

Volume: 25   Issue: 12
Pp: 1385-1391
Caichuan Yan*, Fengmei Li*, Yuhao Zhang, Yang Li, Mingzhu Li, Fang Wang, Guocui Zhang, Yuexin Li, Baoxin Li and Xin Zhao
DOI:10.2174/1381612817666190619123610

Therapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight open Access plus

Volume: 25   Issue: 9
Pp: 946-955
Toru Ishibashi*
DOI:10.2174/1381612825666190506123038

Emerging Therapeutic Targets in Oncologic Photodynamic Therapy open Access plus

Volume: 24   Issue: 44
Pp: 5268-5295
Gina Manda*, Mihail E. Hinescu, Ionela V. Neagoe, Luis F.V. Ferreira, Rica Boscencu, Paul Vasos, Selma H. Basaga and Antonio Cuadrado
DOI:10.2174/1381612825666190122163832

Role of Advanced Glycation End Products in Carcinogenesis and their Therapeutic Implications open Access plus

Volume: 24   Issue: 44
Pp: 5245-5251
David Schröter and Annika Höhn*
DOI:10.2174/1381612825666190130145549

Dietary Approaches to Attain Fish Health with Special Reference to their Immune System open Access plus

Volume: 24   Issue: 41
Pp: 4921-4931
Thea Magrone*, Matteo A. Russo and Emilio Jirillo
DOI:10.2174/1381612825666190104121544

Small Molecules as PD-1/PD-L1 Pathway Modulators for Cancer Immunotherapy open Access plus

Volume: 24   Issue: 41
Pp: 4911-4920
Peifu Jiao, Qiaohong Geng*, Peng Jin, Gaoxing Su, Houyun Teng, Jinlong Dong and Bing Yan*
DOI:10.2174/1381612824666181112114958

Advantages of Vasoactive Intestinal Peptide for the Future Treatment of Parkinson’s Disease open Access plus

Volume: 24   Issue: 39
Pp: 4693-4701
Orhan Tansel Korkmaz and Neşe Tunçel*
DOI:10.2174/1381612825666190111150953

Machine Learning-based Virtual Screening and Its Applications to Alzheimer’s Drug Discovery: A Review open Access plus

Volume: 24   Issue: 28
Pp: 3347-3358
Kristy A. Carpenter and Xudong Huang*
DOI:10.2174/1381612824666180607124038

Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis open Access plus

Volume: 24   Issue: 26
Pp: 3143-3151
Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky
DOI:10.2174/1381612824666180911120039

Novel Technologies for Dipeptide Drugs Design and their Implantation open Access plus

Volume: 24   Issue: 26
Pp: 3020-3027
Tatiana A. Gudasheva*, Rita U. Ostrovskaya and Sergey B. Seredenin
DOI:10.2174/1381612824666181008105641

Coronary Microcirculation in Ischemic Heart Disease open Access plus

Volume: 24   Issue: 25
Pp: 2893-2899
Axel R. Pries*, Wolfgang M. Kuebler and Helmut Habazettl
DOI:10.2174/1381612824666180625142341

Next-generation Metabolomics in the Development of New Antidepressants: Using Albiflorin as an Example open Access plus

Volume: 24   Issue: 22
Pp: 2530-2540
Jian Han, Yonghong Xia, Lejun Lin, Zuoguang Zhang, Hui Tian and Kefeng Li*
DOI:10.2174/1381612824666180727114134

Role of Heme Oxygenases in Cardiovascular Syndromes and Co-morbidities open Access plus

Volume: 24   Issue: 20
Pp: 2322-2325
David D. Haines and Arpad Tosaki*
DOI:10.2174/1381612824666180727110353

Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production open Access plus

Volume: 24   Issue: 18
Pp: 2012-2022
Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*
DOI:10.2174/1381612824666180515125654

Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach open Access plus

Volume: 24   Issue: 13
Pp: 1366-1376
Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*
DOI:10.2174/1381612824666171201115126

Development of Peptide Vaccines in Dengue open Access plus

Volume: 24   Issue: 11
Pp: 1157-1173
Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*
DOI:10.2174/1381612823666170913163904

Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems open Access plus

Volume: 24   Issue: 6
Pp: 710-717
Osamu Kanauchi*, Akira Andoh, Sazaly AbuBakar and Naoki Yamamoto
DOI:10.2174/1381612824666180116163411

Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity open Access plus

Volume: 24   Issue: 5
Pp: 576-594
Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo
DOI:10.2174/1381612823666170711112510

Safety Strategies of Genetically Engineered T Cells in Cancer Immunotherapy open Access plus

Volume: 24   Issue: 1
Pp: 78-83
Yan-Bei Ren, Shang-Jun Sun and Shuang-Yin Han*
DOI:10.2174/1381612824666171227222624

2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1 open Access plus

Volume: 23   Issue: 40
Pp: 6231-6238
Pericles Calias*
DOI:10.2174/1381612823666171019164220

IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development open Access plus

Volume: 23   Issue: 38
Pp: 5964-5970
Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard
DOI:10.2174/1381612823666171002114545

A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension open Access plus

Volume: 23   Issue: 34
Pp: 5191-5199
Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*
DOI:10.2174/1381612823666170908114227

A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure open Access plus

Volume: 23   Issue: 34
Pp: 5115-5124
Yong Wang*, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu* and Wei Wang*
DOI:10.2174/1381612823666170925163427

Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer open Access plus

Volume: 23   Issue: 32
Pp: 4827-4841
Jack Tuszynski, Tatiana M. Tilli and Michael Levin*
DOI:10.2174/1381612823666170530105837

Protein Kinase Inhibitors as Therapeutic Drugs in AML: Advances and Challenges open Access plus

Volume: 23   Issue: 29
Pp: 4303-4310
Yuan Ling, Zikang Zhang, Hua Zhang* and Zunnan Huang*
DOI:10.2174/1381612823666170703164114

Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress open Access plus

Volume: 23   Issue: 27
Pp: 4066-4075
Akinori Yanaka*
DOI:10.2174/1381612823666170207103943

Hydrogel-Based Cell Therapies for Kidney Regeneration: Current Trends in Biofabrication and In Vivo Repair open Access plus

Volume: 23   Issue: 26
Pp: 3845-3857
Katja Jansen*, Carl C.L. Schuurmans*, Jitske Jansen, Rosalinde Masereeuw* and Tina Vermonden*
DOI:10.2174/1381612823666170710155726

Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates open Access plus

Volume: 23   Issue: 15
Pp: 2276-2286
Ulviye Acar Cevik, Begum Nurpelin Saglik, Yusuf Ozkay*, Zerrin Canturk, Juan Bueno, Fatih Demirci and Ali Savas Koparal
DOI:10.2174/1381612822666161201150131

Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin open Access plus

Volume: 23   Issue: 14
Pp: 2131-2138
Xinya Hemu and James P. Tam*
DOI:10.2174/1381612822666161027120518

Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma open Access plus

Volume: 23   Issue: 14
Pp: 2113-2116
Pei-pei Ren, Ming Li, Tian-fang Li and Shuang-yin Han*
DOI:10.2174/1381612823666170316125402

Selective Inhibition of Phosphodiesterases 4A, B, C and D Isoforms in Chronic Respiratory Diseases: Current and Future Evidences open Access plus

Volume: 23   Issue: 14
Pp: 2073-2083
Sonia Contreras*, Javier Milara*, Esteban Morcillo and Julio Cortijo
DOI:10.2174/1381612823666170214105651

Neural Circuits Underlying Fly Larval Locomotion open Access plus

Volume: 23   Issue: 12
Pp: 1722-1733
Hiroshi Kohsaka*, Pierre A. Guertin and Akinao Nose
DOI:10.2174/1381612822666161208120835

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases open Access plus

Volume: 23   Issue: 7
Pp: 1077-1097
Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao* and Dongwei Zhang*
DOI:10.2174/1381612822666161010105242

Polypharmacology in Precision Oncology: Current Applications and Future Prospects open Access plus

Volume: 22   Issue: 46
Pp: 6935-6945
Albert A. Antolin, Paul Workman, Jordi Mestres and Bissan Al-Lazikani
DOI:10.2174/1381612822666160923115828

From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine open Access plus

Volume: 22   Issue: 46
Pp: 6903-6910
Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini
DOI:10.2174/1381612822666160905095402

Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans open Access plus

Volume: 22   Issue: 44
Pp: 6701-6715
Mauro Serafini and Ilaria Peluso
DOI:10.2174/1381612823666161123094235

Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? open Access plus

Volume: 22   Issue: 40
Pp: 6107-6121
John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E. Frye
DOI:10.2174/1381612822666160905123953

Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier open Access plus

Volume: 22   Issue: 35
Pp: 5463-5476
Nathalie Strazielle and Jean-François Ghersi-Egea
DOI:10.2174/1381612822666160726112115

The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review open Access plus

Volume: 22   Issue: 27
Pp: 4264-4287
Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto
DOI:10.2174/1381612822666160623070829

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species open Access plus

Volume: 22   Issue: 26
Pp: 3950-3970
Francesco Simone Ruggeri, Johnny Habchi, Andrea Cerreta and Giovanni Dietler
DOI:10.2174/1381612822666160518141911

Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics open Access plus

Volume: 22   Issue: 23
Pp: 3555-3568
Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda
DOI:10.2174/1381612822666160414142547

Therapeutic Targets for Management of Periodontitis and Diabetes open Access plus

Volume: 22   Issue: 15
Pp: 2216-2237
Corneliu Sima and Thomas E. Van Dyke
DOI:10.2174/1381612822666160216150338

The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory open Access plus

Volume: 22   Issue: 12
Pp: 1756-1766
Mohammed I. Khan, Anna A. Sobocińska, Anna M. Czarnecka, Magdalena Król, Bruno Botta and Cezary Szczylik
DOI:10.2174/1381612822666151211094901

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier open Access plus

Volume: 22   Issue: 9
Pp: 1177-1193
David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Frenkel, Jeffrey A. Winkles, Graeme F. Woodworth and Anthony J. Kim
DOI:10.2174/1381612822666151221150733

Recent advances in the fundamental understanding of adhesive mixtures for inhalation open Access plus

Volume: 21   Issue: 40
Pp: 5900-5914
Floris Grasmeijer, Niels Grasmeijer, Paul Hagedoorn, Henderik Willem Frijlink and Anne Haaije de Boer
DOI:10.2174/1381612821666151008124622

Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker open Access plus

Volume: 21   Issue: 26
Pp: 3797-3806
Kenji Hashimoto
DOI:10.2174/1381612821666150605111345

Lipid-Based Nanocarriers for RNA Delivery open Access plus

Volume: 21   Issue: 22
Pp: 3140-3147
Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen and Ho Lun Wong
DOI:10.2174/1381612821666150531164540

Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations open Access plus

Volume: 21   Issue: 19
Pp: 2677-2694
Daryl R. Williams
DOI:10.2174/1381612821666150416100319

Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus open Access plus

Volume: 21   Issue: 16
Pp: 2054-2057
Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M. Coque, Ian Morrissey and behalf of the BIOHYPO consortium
DOI:10.2174/1381612821666150310103238

Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy open Access plus

Volume: 21   Issue: 9
Pp: 1172-1179
Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska
DOI:10.2174/1381612820666141013120459

Assessment and Relevance of Carotid Intima-Media Thickness (C-IMT) in Primary and Secondary Cardiovascular Prevention open Access plus

Volume: 21   Issue: 9
Pp: 1164-1171
Alessio Ravani, Jose Pablo Werba, Beatrice Frigerio, Daniela Sansaro, Mauro Amato, Elena Tremoli and Damiano Baldassarre
DOI:10.2174/1381612820666141013121545

Antihypertensive Drugs Metabolism: An Update to Pharmacokinetic Profiles and Computational Approaches open Access plus

Volume: 21   Issue: 6
Pp: 806-822
Aikaterini Zisaki, Ljubisa Miskovic and Vassily Hatzimanikatis
DOI:10.2174/1381612820666141024151119

Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure open Access plus

Volume: 21   Issue: 4
Pp: 431-448
Asmund T. Roe, Michael Frisk and William E. Louch
DOI:10.2174/138161282104141204124129

Biomarkers Predicting a Need for Intensive Treatment in Patients with Early Arthritis open Access plus

Volume: 21   Issue: 2
Pp: 170-181
I. Gonzalez-Alvaro, A.M. Ortiz, I.V. Seoane, R. Garcia-Vicuna, C. Martinez and R.P. Gomariz
DOI:10.2174/1381612820666140825123104

Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy open Access plus

Volume: 20   Issue: 42
Pp: 6584-6643
Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur
DOI:10.2174/1381612820666140826153913

Tankyrases: Structure, Function and Therapeutic Implications in Cancer open Access plus

Volume: 20   Issue: 41
Pp: 6472-6488
Teemu Haikarainen, Stefan Krauss and Lari Lehtio
DOI:10.2174/1381612820666140630101525

Telomere Maintenance Mechanisms in Cancer: Clinical Implications open Access plus

Volume: 20   Issue: 41
Pp: 6361-6374
Roger R. Reddel
DOI:10.2174/1381612820666140630101047

Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies open Access plus

Volume: 20   Issue: 36
Pp: 5779-5793
Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito and Hiroyuki Kinoshita
DOI:10.2174/1381612820666140204102044

Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System open Access plus

Volume: 20   Issue: 29
Pp: 4707-4722
Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne and Carmen Guaza
DOI:10.2174/1381612820666140130202911

Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection open Access plus

Volume: 20   Issue: 14
Pp: 2387-2394
Angelo Avogaro, Saula de Kreutzenberg and Gianpaolo Fadini
DOI:10.2174/13816128113199990474

Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings open Access plus

Volume: 20   Issue: 13
Pp: 2126-2137
Johannes Wrege, Andre Schmidt, Anna Walter, Renata Smieskova, Kerstin Bendfeldt, Ernst-Wilhelm Radue, Undine E. Lang and Stefan Borgwardt
DOI:10.2174/13816128113199990428

New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib open Access plus

Volume: 20   Issue: 7
Pp: 1097-1103
Masahiko Nakamura, Tetsufumi Takahashi, Hidenori Matsui, Shinichi Takahashi, Somay Y. Murayama, Hidekazu Suzuki and Kanji Tsuchimoto
DOI:10.2174/13816128113199990420

Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles open Access plus

Volume: 20   Issue: 1
Pp: 23-36
Jing Tang and Tero Aittokallio
DOI:10.2174/13816128113199990470