Abstract
Proteins are functional molecules in cells and are the major targets for drug action. To design a rational drug, we must firstly find out which proteins can be the drug targets in pathogenesis. Proteomics has great promise in identification of protein targets and biochemical pathways involved in disease processes. Proteomics as a whole increasingly plays an important role in the multi-step drug-development process. The process includes target identification and validation, lead selection, small-molecular screening and optimization, and toxicity testing. Furthermore, sub-disciplines such as computational proteomics, chemical proteomics, structural proteomics and topological proteomics offer significant contributions especially in computer-aided drug design. This review will summarize the recent progress in pharmaco-proteomics and the disciplines potential application in computer-assisted drug design.
Keywords: proteomics, drug design, drug target, protein target, target identification, lead validation, computer-aided drug design, protein profiling
Current Computer-Aided Drug Design
Title: Proteomics in Computer-Aided Drug Design
Volume: 1 Issue: 1
Author(s): Ying Wang, Jen-Fu Chiu and Qing-Yu He
Affiliation:
Keywords: proteomics, drug design, drug target, protein target, target identification, lead validation, computer-aided drug design, protein profiling
Abstract: Proteins are functional molecules in cells and are the major targets for drug action. To design a rational drug, we must firstly find out which proteins can be the drug targets in pathogenesis. Proteomics has great promise in identification of protein targets and biochemical pathways involved in disease processes. Proteomics as a whole increasingly plays an important role in the multi-step drug-development process. The process includes target identification and validation, lead selection, small-molecular screening and optimization, and toxicity testing. Furthermore, sub-disciplines such as computational proteomics, chemical proteomics, structural proteomics and topological proteomics offer significant contributions especially in computer-aided drug design. This review will summarize the recent progress in pharmaco-proteomics and the disciplines potential application in computer-assisted drug design.
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Cite this article as:
Wang Ying, Chiu Jen-Fu and He Qing-Yu, Proteomics in Computer-Aided Drug Design, Current Computer-Aided Drug Design 2005; 1 (1) . https://dx.doi.org/10.2174/1573409052952260
DOI https://dx.doi.org/10.2174/1573409052952260 |
Print ISSN 1573-4099 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6697 |
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